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Dmrta2 doublesex and mab-3 related transcription factor like family A2 [ Mus musculus (house mouse) ]

Gene ID: 242620, updated on 2-Nov-2024

Summary

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Official Symbol
Dmrta2provided by MGI
Official Full Name
doublesex and mab-3 related transcription factor like family A2provided by MGI
Primary source
MGI:MGI:2653629
See related
Ensembl:ENSMUSG00000047143 AllianceGenome:MGI:2653629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dmrt5
Summary
Enables identical protein binding activity and sequence-specific DNA binding activity. Acts upstream of or within several processes, including nervous system development; positive regulation of neuroblast proliferation; and stem cell fate specification. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human DMRTA2 (DMRT like family A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 8.1), CNS E14 (RPKM 5.1) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Dmrta2 in Genome Data Viewer
Location:
4 C7; 4 51.37 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (109835222..109840896)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109977989..109983691)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase inhibitor 2C Neighboring gene Fas-associated factor 1 Neighboring gene STARR-seq mESC enhancer starr_11075 Neighboring gene STARR-seq mESC enhancer starr_11076 Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_11077 Neighboring gene STARR-seq mESC enhancer starr_11078 Neighboring gene predicted gene, 33070 Neighboring gene ELAV like RNA binding protein 4 Neighboring gene predicted gene, 54251

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1. Young FI, et al. Proc Natl Acad Sci U S A, 2017 Jul 11. PMID 28655839, Free PMC Article
  2. Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies. Poulain M, et al. Mol Hum Reprod, 2014 Oct. PMID 25082981
  3. Doublesex and mab-3-related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fate. Gennet N, et al. Proc Natl Acad Sci U S A, 2011 May 31. PMID 21576465, Free PMC Article
  4. The function of Dmrt genes in vertebrate development: it is not just about sex. Hong CS, et al. Dev Biol, 2007 Oct 1. PMID 17720152
  5. Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus. Muralidharan B, et al. J Neurosci, 2017 Nov 15. PMID 29025924, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis.
    Title: Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis.
  2. Study suggests that DMRT3/5 function with EMX2 in positioning the pallial-subpallial boundary by antagonizing the ventral homeobox transcription factor GSX2.
    Title: DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors.
  3. Finely tuned levels of DMRT5, together with DMRT3, regulate patterning of the cerebral cortex.
    Title: DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation.
  4. there is a link between Dmrta2 modulation of Hes1 expression and the maintenance of neural progenitor cells during cortical development
    Title: The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.
  5. Dmrt5 is neurogenic, and reciprocally regulated by Lhx2; loss of either factor promotes gliogenesis.
    Title: Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus.
  6. Dmrt5 is a novel Wnt-dependent transcription factor required for early cortical development
    Title: The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals.
  7. data suggest that Dmrta2 plays pivotal roles in the early development of the telencephalon via the formation of the cortical hem, a source of Wnts, and also in the maintenance of neural progenitors as a downstream of the Wnt pathway
    Title: The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex.
  8. Dmrt5 is an important player in ventral mesencephalic neural fate specification
    Title: Doublesex and mab-3-related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fate.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cerebral cortex regionalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sex differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stem cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
doublesex- and mab-3-related transcription factor A2
Names
doublesex- and mab-3-related transcription factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172296.2 → NP_758500.2  doublesex- and mab-3-related transcription factor A2

    See identical proteins and their annotated locations for NP_758500.2

    Status: VALIDATED

    Source sequence(s)
    AI465212, AL627188, AY145837, CJ172393
    Consensus CDS
    CCDS18469.1
    UniProtKB/Swiss-Prot
    A2A9A2, Q8CFF8
    Related
    ENSMUSP00000060441.4, ENSMUST00000061187.4
    Conserved Domains (2) summary
    cd14418
    Location:308 → 349
    CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)
    pfam00751
    Location:65 → 111
    DM; DM DNA binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    109835222..109840896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503093.5 → XP_006503156.1  doublesex- and mab-3-related transcription factor A2 isoform X1

    See identical proteins and their annotated locations for XP_006503156.1

    UniProtKB/Swiss-Prot
    A2A9A2, Q8CFF8
    Conserved Domains (2) summary
    cd14418
    Location:308 → 349
    CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)
    pfam00751
    Location:65 → 111
    DM; DM DNA binding domain

  2. XM_006503094.5 → XP_006503157.1  doublesex- and mab-3-related transcription factor A2 isoform X1

    See identical proteins and their annotated locations for XP_006503157.1

    UniProtKB/Swiss-Prot
    A2A9A2, Q8CFF8
    Conserved Domains (2) summary
    cd14418
    Location:308 → 349
    CUE_DMA_DMRTA2; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2)
    pfam00751
    Location:65 → 111
    DM; DM DNA binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A9A2.1 GenPept UniProtKB/Swiss-Prot:A2A9A2

Gene LinkOut

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