Comt catechol-O-methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Comtprovided by RGD
Official Full Name: catechol-O-methyltransferaseprovided by RGD
Primary source: RGD:2379
See related: EnsemblRapid:ENSRNOG00000001889 AllianceGenome:RGD:2379
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables catechol O-methyltransferase activity. Involved in several processes, including learning or memory; negative regulation of dopamine metabolic process; and positive regulation of homocysteine metabolic process. Located in several cellular components, including cell body; dendritic spine; and postsynaptic membrane. Is active in glutamatergic synapse and postsynapse. Used to study Parkinsonism and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of skin and connective tissue (multiple); cognitive disorder (multiple); drug dependence (multiple); reproductive organ cancer (multiple); and withdrawal disorder (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 2550.1), Kidney (RPKM 1227.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (96072371..96091956)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (82568052..82587642)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (86715981..86735630)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of Catechol-O-methyltransferase Regulating Orofacial Pain Induced by Tooth Movement.
Title: Mechanism of Catechol-O-methyltransferase Regulating Orofacial Pain Induced by Tooth Movement.
Catechol-O-methyltransferase and Pregnancy Outcome: an Appraisal in Rat.
Title: Catechol-O-methyltransferase and Pregnancy Outcome: an Appraisal in Rat.
Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain.
Title: Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain.
The discovered changes in the expression level of catechol-o-methyltransferase , mineralocorticoid receptor , and b-subunit of epithelial sodium channel confirm their involvement in increased sympathetic stimulation of the of hypertensive rats
Title: [Expression of Catechol-O-Methyltransferase (Comt), Mineralocorticoid Receptor (Mlr), and Epithelial Sodium Channel (ENaC) Genes in Kidneys of Hypertensive ISIAH Rats at Rest and during Response to Stress].
A higher hepatic COMT activity was found in the mineral water group compared with the tap water and tap-water-plus-NaCl groups. On the other hand, adrenal gland COMT mRNA expression decreased in the MW group compared to TW group.
Title: Effect of a natural mineral-rich water on catechol-O-methyltransferase function.
COMT inhibition results in increased pain sensitivity and production of proinflammatory mediators.
Title: β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines.
Our findings suggest that COMT regulates dorsal hippocampal neurochemistry and modulates hippocampus-dependent behaviours.
Title: Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition.
ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2
Title: ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2.
decreased COMT activity was associated with some changes in feeding microstructure in rats and mice
Title: A transient inhibition and permanent lack of catechol-O-methyltransferase have minor effects on feeding pattern of female rodents.
investigation of substrate specificity and metabolite profiles of COMT from liver cytosol; studies include molecular modeling
Title: Methylation of catechins and procyanidins by rat and human catechol-O-methyltransferase: metabolite profiling and molecular modeling studies.

Submit: New GeneRIF Correction See all GeneRIFs (26)

General gene information

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Markers

D11Mgh8 (e-PCR)
- UniSTS:239400

D11Mgh1 (e-PCR), detects polymorphism
- UniSTS:119429

D11Wox6 (e-PCR)
- UniSTS:517784

RH128045 (e-PCR)
- UniSTS:211353

Comt (e-PCR), detects polymorphism
- UniSTS:496796

RH94723 (e-PCR)
- UniSTS:119970

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables catechol O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables catechol O-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables catechol O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables catechol O-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in S-adenosylhomocysteine metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in S-adenosylmethionine metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within artery development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in catecholamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in catecholamine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in catecholamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in catecholamine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within catecholamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to cocaine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to phosphate starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellar cortex morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol efflux	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
involved_in developmental process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dopamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dopamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopamine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dopamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exploration behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fear response	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glomerulus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycogen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within habituation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mastication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in methylation	ISO Inferred from Sequence Orthology more info
involved_in methylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal response to stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within norepinephrine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within norepinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of homocysteine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lactation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein methylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal albumin absorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal filtration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal sodium excretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renin secretion into blood stream	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to amphetamine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to angiotensin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to corticosterone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cytokine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to dopamine	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to food	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to salt	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to temperature stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to toxic substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within startle response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic transmission, dopaminergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: catechol O-methyltransferase

Names: catecholamine-O-methyltransferase

NP_036663.1

EC 2.1.1.6

XP_006248665.1

EC 2.1.1.6

XP_063126344.1

EC 2.1.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012531.2 → NP_036663.1 catechol O-methyltransferase

See identical proteins and their annotated locations for NP_036663.1

Status: VALIDATED

Source sequence(s)

BC081850, CK478774

UniProtKB/Swiss-Prot

P22734

UniProtKB/TrEMBL

A0A8I6AHB1, F2W8B0, F2W8B1

Related

ENSRNOP00000092582.1, ENSRNOT00000104392.2

Conserved Domains (1) summary

COG4122
Location:44 → 238

YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

96072371..96091956

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270274.1 → XP_063126344.1 catechol O-methyltransferase isoform X2

UniProtKB/Swiss-Prot

P22734

UniProtKB/TrEMBL

F2W8B0, F2W8B1

Related

ENSRNOP00000043148.5, ENSRNOT00000050269.7
XM_006248603.5 → XP_006248665.1 catechol O-methyltransferase isoform X1

UniProtKB/TrEMBL

A0A8I6A1I0, A0A8I6AHB1

Related

ENSRNOP00000086073.1, ENSRNOT00000119057.2

Conserved Domains (1) summary

cl17173
Location:61 → 228

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...