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Lrrd1 leucine rich repeats and death domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 242838, updated on 2-Nov-2024

Summary

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Official Symbol
Lrrd1provided by MGI
Official Full Name
leucine rich repeats and death domain containing 1provided by MGI
Primary source
MGI:MGI:3045299
See related
Ensembl:ENSMUSG00000040367 AllianceGenome:MGI:3045299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932412H11Rik
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. Orthologous to human LRRD1 (leucine rich repeats and death domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 2.4), adrenal adult (RPKM 0.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrd1 in Genome Data Viewer
Location:
5 A1; 5 2.26 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (3895173..3916596)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (3845173..3866596)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and IBR domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E4742 Neighboring gene STARR-seq mESC enhancer starr_12318 Neighboring gene KRIT1, ankyrin repeat containing Neighboring gene STARR-seq mESC enhancer starr_12319 Neighboring gene STARR-seq mESC enhancer starr_12320 Neighboring gene mitochondrial transcription termination factor 1a Neighboring gene STARR-positive B cell enhancer ABC_E1296 Neighboring gene Rps4x retrotransposed pseudogene Neighboring gene STARR-seq mESC enhancer starr_12321 Neighboring gene predicted gene, 51438 Neighboring gene A kinase anchor protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice. Suzuki A, et al. J Reprod Immunol, 2024 Jun. PMID 38697008,
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat and death domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172879.3 → NP_766467.2  leucine-rich repeat and death domain-containing protein 1

    See identical proteins and their annotated locations for NP_766467.2

    Status: VALIDATED

    Source sequence(s)
    AC022236, AC027653
    Consensus CDS
    CCDS19068.1
    UniProtKB/Swiss-Prot
    B2RU96, Q8C0R9
    Related
    ENSMUSP00000038675.2, ENSMUST00000044039.2
    Conserved Domains (4) summary
    cd00116
    Location:315 → 582
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:207 → 229
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:573 → 612
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:251 → 309
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    3895173..3916596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0R9.2 GenPept UniProtKB/Swiss-Prot:Q8C0R9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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