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Lrrc61 leucine rich repeat containing 61 [ Mus musculus (house mouse) ]

Gene ID: 243371, updated on 2-Nov-2024

Summary

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Official Symbol
Lrrc61provided by MGI
Official Full Name
leucine rich repeat containing 61provided by MGI
Primary source
MGI:MGI:2652848
See related
Ensembl:ENSMUSG00000073096 AllianceGenome:MGI:2652848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. Orthologous to human LRRC61 (leucine rich repeat containing 61). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver adult (RPKM 24.9), testis adult (RPKM 17.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrc61 in Genome Data Viewer
Location:
6 B2.3; 6 23.54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48531732..48547656)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48554780..48570722)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700026J14 gene Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit E2 Neighboring gene STARR-positive B cell enhancer ABC_E9271 Neighboring gene retinoic acid receptor responder (tazarotene induced) 2 Neighboring gene predicted gene 5111 Neighboring gene replication initiator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC28139

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110160.2 → NP_001103630.1  leucine-rich repeat-containing protein 61

    See identical proteins and their annotated locations for NP_001103630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All 8 variants encode the same protein.
    Source sequence(s)
    AC154013
    Consensus CDS
    CCDS39478.1
    UniProtKB/Swiss-Prot
    Q3TB45, Q3UPT0, Q8R2R5
    UniProtKB/TrEMBL
    A0A0R4J1J6
    Related
    ENSMUSP00000098979.3, ENSMUST00000101436.3
    Conserved Domains (2) summary
    sd00033
    Location:55 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:43 → 138
    internalin_A; class 1 internalin InlA

  2. NM_001411645.1 → NP_001398574.1  leucine-rich repeat-containing protein 61

    Status: VALIDATED

    Source sequence(s)
    AC154013
    UniProtKB/TrEMBL
    A0A0R4J1J6

  3. NM_001411646.1 → NP_001398575.1  leucine-rich repeat-containing protein 61

    Status: VALIDATED

    Source sequence(s)
    AC154013
    UniProtKB/TrEMBL
    A0A0R4J1J6

  4. NM_001411647.1 → NP_001398576.1  leucine-rich repeat-containing protein 61

    Status: VALIDATED

    Source sequence(s)
    AC154013
    UniProtKB/TrEMBL
    A0A0R4J1J6

  5. NM_001411648.1 → NP_001398577.1  leucine-rich repeat-containing protein 61

    Status: VALIDATED

    Source sequence(s)
    AC154013
    UniProtKB/TrEMBL
    A0A0R4J1J6

  6. NM_001411649.1 → NP_001398578.1  leucine-rich repeat-containing protein 61

    Status: VALIDATED

    Source sequence(s)
    AC154013
    UniProtKB/TrEMBL
    A0A0R4J1J6

  7. NM_001411650.1 → NP_001398579.1  leucine-rich repeat-containing protein 61

    Status: VALIDATED

    Source sequence(s)
    AC154013
    UniProtKB/TrEMBL
    A0A0R4J1J6

  8. NM_177736.4 → NP_808404.2  leucine-rich repeat-containing protein 61

    See identical proteins and their annotated locations for NP_808404.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All 8 variants encode the same protein.
    Source sequence(s)
    AC154013
    Consensus CDS
    CCDS39478.1
    UniProtKB/Swiss-Prot
    Q3TB45, Q3UPT0, Q8R2R5
    UniProtKB/TrEMBL
    A0A0R4J1J6
    Related
    ENSMUSP00000110192.2, ENSMUST00000114545.8
    Conserved Domains (2) summary
    sd00033
    Location:55 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:43 → 138
    internalin_A; class 1 internalin InlA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48531732..48547656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2R5.1 GenPept UniProtKB/Swiss-Prot:Q8R2R5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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