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Gprin3 GPRIN family member 3 [ Mus musculus (house mouse) ]

Gene ID: 243385, updated on 2-Nov-2024

Summary

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Official Symbol
Gprin3provided by MGI
Official Full Name
GPRIN family member 3provided by MGI
Primary source
MGI:MGI:1924785
See related
Ensembl:ENSMUSG00000045441 AllianceGenome:MGI:1924785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C730021L23; C030038J10Rik
Summary
Predicted to be involved in neuron projection development. Predicted to be active in plasma membrane. Is expressed in lung. Orthologous to human GPRIN3 (GPRIN family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 1.1), lung adult (RPKM 0.9) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Gprin3 in Genome Data Viewer
Location:
6 B3; 6 28.48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (59317988..59403291, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (59344500..59426306, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16030 Neighboring gene predicted gene, 22367 Neighboring gene STARR-seq mESC enhancer starr_16031 Neighboring gene STARR-positive B cell enhancer ABC_E4830 Neighboring gene STARR-positive B cell enhancer ABC_E8106 Neighboring gene STARR-seq mESC enhancer starr_16032 Neighboring gene STARR-seq mESC enhancer starr_16034 Neighboring gene STARR-seq mESC enhancer starr_16035 Neighboring gene tigger transposable element derived 2 Neighboring gene STARR-seq mESC enhancer starr_16038 Neighboring gene STARR-seq mESC enhancer starr_16039 Neighboring gene STARR-seq mESC enhancer starr_16041 Neighboring gene STARR-seq mESC enhancer starr_16042 Neighboring gene STARR-seq mESC enhancer starr_16043 Neighboring gene predicted gene, 35195 Neighboring gene predicted gene, 22622 Neighboring gene STARR-seq mESC enhancer starr_16044 Neighboring gene STARR-seq mESC enhancer starr_16045 Neighboring gene STARR-seq mESC enhancer starr_16047 Neighboring gene deoxycytidine kinase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of G protein-regulated inducer of neurite outgrowth 3 (GRIN3) in β-arrestin 2-Akt signaling and dopaminergic behaviors. Mototani Y, et al. Pflugers Arch, 2018 Jun. PMID 29500670
  2. GPRIN3 Controls Neuronal Excitability, Morphology, and Striatal-Dependent Behaviors in the Indirect Pathway of the Striatum. Karadurmus D, et al. J Neurosci, 2019 Sep 18. PMID 31363062, Free PMC Article
  3. Identification and biochemical analysis of GRIN1 and GRIN2. Iida N, et al. Methods Enzymol, 2004. PMID 15488195
  4. Proteomic analysis of in vivo phosphorylated synaptic proteins. Collins MO, et al. J Biol Chem, 2005 Feb 18. PMID 15572359
  5. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we identified GPRIN3 as a putative selective controller of D2R function in the striatum playing a critical role in striatal-associated behaviors and cellular functions
    Title: GPRIN3 Controls Neuronal Excitability, Morphology, and Striatal-Dependent Behaviors in the Indirect Pathway of the Striatum.
  2. GRIN3 is involved in regulation of dopamine-dependent behaviors and is essential for activation of the dopamine receptors (DAR)-beta-arrestin signaling cascade.
    Title: Role of G protein-regulated inducer of neurite outgrowth 3 (GRIN3) in β-arrestin 2-Akt signaling and dopaminergic behaviors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G protein-regulated inducer of neurite outgrowth 3
Names
GRIN3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183183.3 → NP_899006.1  G protein-regulated inducer of neurite outgrowth 3

    See identical proteins and their annotated locations for NP_899006.1

    Status: VALIDATED

    Source sequence(s)
    AC131708
    Consensus CDS
    CCDS20199.1
    UniProtKB/Swiss-Prot
    Q69Z30, Q8BWS5
    UniProtKB/TrEMBL
    B2RQZ6
    Related
    ENSMUSP00000051805.5, ENSMUST00000051065.6
    Conserved Domains (1) summary
    pfam15235
    Location:637 → 758
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    59317988..59403291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506084.4 → XP_006506147.2  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    Conserved Domains (2) summary
    PTZ00449
    Location:565 → 709
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15235
    Location:723 → 844
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BWS5.1 GenPept UniProtKB/Swiss-Prot:Q8BWS5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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