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Uroc1 urocanase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 243537, updated on 2-Nov-2024

Summary

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Official Symbol
Uroc1provided by MGI
Official Full Name
urocanase domain containing 1provided by MGI
Primary source
MGI:MGI:2385332
See related
Ensembl:ENSMUSG00000034456 AllianceGenome:MGI:2385332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable urocanate hydratase activity. Predicted to be involved in L-histidine catabolic process. Predicted to be located in cytosol. Is expressed in alimentary system; liver; and liver lobe. Human ortholog(s) of this gene implicated in urocanase deficiency. Orthologous to human UROC1 (urocanate hydratase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 160.1), liver E18 (RPKM 41.1) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Uroc1 in Genome Data Viewer
Location:
6 D1; 6 40.15 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (90310221..90341533)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (90333239..90364551)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC048671 Neighboring gene carbohydrate sulfotransferase 13 Neighboring gene STARR-positive B cell enhancer ABC_E10392 Neighboring gene STARR-seq mESC enhancer starr_16614 Neighboring gene ZXD family zinc finger C Neighboring gene STARR-seq mESC enhancer starr_16615 Neighboring gene cilia and flagella associated protein 100 Neighboring gene predicted gene, 53295

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC37818

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables urocanate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables urocanate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables urocanate hydratase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-histidine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-histidine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-histidine catabolic process to glutamate and formamide IEA
Inferred from Electronic Annotation
more info
  
involved_in L-histidine catabolic process to glutamate and formate IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
urocanate hydratase
Names
imidazolonepropionate hydrolase
NP_001334258.1
NP_659189.2
XP_006506155.1
XP_006506156.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347329.1 → NP_001334258.1  urocanate hydratase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC163346, AK149464
    Consensus CDS
    CCDS85094.1
    UniProtKB/TrEMBL
    Q3UEL5
    Related
    ENSMUSP00000127114.2, ENSMUST00000164761.6

  2. NM_144940.2 → NP_659189.2  urocanate hydratase isoform 2

    See identical proteins and their annotated locations for NP_659189.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC163346, AK149464
    Consensus CDS
    CCDS39561.1
    UniProtKB/Swiss-Prot
    E9QNN2, Q8VC12
    Related
    ENSMUSP00000040424.10, ENSMUST00000046128.12
    Conserved Domains (1) summary
    PRK05414
    Location:74 → 662
    PRK05414; urocanate hydratase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    90310221..90341533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506093.4 → XP_006506156.1  urocanate hydratase isoform X2

    Conserved Domains (1) summary
    cl19311
    Location:74 → 448
    Urocanase; Urocanase Rossmann-like domain

  2. XM_006506092.2 → XP_006506155.1  urocanate hydratase isoform X1

    Conserved Domains (1) summary
    cl19311
    Location:1 → 555
    Urocanase; Urocanase Rossmann-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC12.2 GenPept UniProtKB/Swiss-Prot:Q8VC12

Gene LinkOut

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