Fabp1 fatty acid binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fabp1provided by RGD
Official Full Name: fatty acid binding protein 1provided by RGD
Primary source: RGD:2590
See related: EnsemblRapid:ENSRNOG00000006675 AllianceGenome:RGD:2590
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SCP; p14; SCP.; Fabplg; L-FABP
Summary: Enables several functions, including long-chain fatty acid transmembrane transporter activity; monocarboxylic acid binding activity; and phospholipid binding activity. Involved in several processes, including long-chain fatty acid transport; positive regulation of fatty acid beta-oxidation; and response to vitamin B3. Located in apical cortex and peroxisomal matrix. Part of protein-containing complex. Biomarker of end stage renal disease. Orthologous to human FABP1 (fatty acid binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 28202.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (104744302..104753119)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (103191015..103194791)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (99063181..99066957)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Urinary liver-type fatty acid binding protein is increased in the early stages of the disease with a risk of acute kidney injury induced by histone.
Title: Urinary liver-type fatty acid binding protein is increased in the early stages of the disease with a risk of acute kidney injury induced by histone.
Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats.
Title: Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats.
Studies show that despite overall tertiary structure similarity, the hFABP1 differs significantly from rat FABP1 in secondary structure, much larger ligand binding cavity, and affinities/specificities for some ligands. Moreover, while both mouse and hFABP1 mediate ligand induction of PPARA, they differ markedly in genes induced.
Title: Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias.
L-FABP structurally and functionally interacts with HNF4alpha.
Title: Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4α.
These results provide strong support for monoacylglycerol as a physiological ligand for LFABP and further suggest that LFABP functions in the efficient intracellular transport of MG
Title: Liver fatty acid-binding protein binds monoacylglycerol in vitro and in mouse liver cytosol.
Phosphorylation of Sar1b protein releases liver fatty acid-binding protein from multiprotein complex in intestinal cytosol enabling it to bind to endoplasmic reticulum (ER) and bud the pre-chylomicron transport vesicle.
Title: Phosphorylation of Sar1b protein releases liver fatty acid-binding protein from multiprotein complex in intestinal cytosol enabling it to bind to endoplasmic reticulum (ER) and bud the pre-chylomicron transport vesicle.
NMR study of liver fatty acid-binding protein
Title: A nuclear magnetic resonance-based structural rationale for contrasting stoichiometry and ligand binding site(s) in fatty acid-binding proteins.
Clofibrate enhanced L-FABP gene transcription and mRNA stability, thus affecting L-FABP expression and ultimately cellular antioxidant activity.
Title: Regulation of liver fatty acid binding protein expression by clofibrate in hepatoma cells.
a direct role of glucose in facilitating L-FABP-mediated uptake and distribution of lipidic ligands to the nucleus for regulation of PPARalpha transcriptional activity
Title: Glucose regulates fatty acid binding protein interaction with lipids and peroxisome proliferator-activated receptor α.
Data show that niacin therapyreduced renal tissue lipids, CD36, ChREBP, LXR, ABCA-1, ABCG-1, and SR-B1 abundance and raised PPAR-alpha and L-FABP.
Title: Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Markers

d4mit12 (e-PCR)
- UniSTS:121926

D4Wox20 (e-PCR)
- UniSTS:239484

D4Arb21 (e-PCR)
- UniSTS:240021

Fabp1 (e-PCR), detects polymorphism
- UniSTS:495834

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables bile acid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid binding	IPI Inferred from Physical Interaction more info	PubMed
enables heterocyclic compound binding	IDA Inferred from Direct Assay more info	PubMed
enables heterocyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lysophospholipid:sodium symporter activity	IC Inferred by Curator more info	PubMed
enables oleic acid binding	IPI Inferred from Physical Interaction more info	PubMed
enables phospholipid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestinal absorption	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysophospholipid transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to vitamin B3	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fatty acid-binding protein, liver

Names: Z-protein; fatty acid binding protein 1, liver; liver-type fatty acid-binding protein; squalene- and sterol-carrier protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012556.2 → NP_036688.1 fatty acid-binding protein, liver

See identical proteins and their annotated locations for NP_036688.1

Status: VALIDATED

Source sequence(s)

BC086947

UniProtKB/Swiss-Prot

P02692

UniProtKB/TrEMBL

A6IA66

Conserved Domains (1) summary

cd19444
Location:2 → 127

FABP1; fatty acid-binding protein 1