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Gp6 glycoprotein 6 platelet [ Mus musculus (house mouse) ]

Gene ID: 243816, updated on 2-Nov-2024

Summary

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Official Symbol
Gp6provided by MGI
Official Full Name
glycoprotein 6 plateletprovided by MGI
Primary source
MGI:MGI:1889810
See related
Ensembl:ENSMUSG00000078810 AllianceGenome:MGI:1889810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpvi; Gm469; 9830166G18Rik
Summary
Enables collagen binding activity and collagen receptor activity. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway; peptidyl-tyrosine phosphorylation; and platelet aggregation. Located in cell surface and plasma membrane. Is expressed in bone marrow; femur; liver; and spleen. Human ortholog(s) of this gene implicated in blood platelet disease (multiple); coronary artery disease (multiple); and type 2 diabetes mellitus. Orthologous to human GP6 (glycoprotein VI platelet). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Gp6 in Genome Data Viewer
Location:
7 A1; 7 2.52 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4365852..4400849, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4362853..4397851, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15931 Neighboring gene STARR-seq mESC enhancer starr_17925 Neighboring gene STARR-seq mESC enhancer starr_17927 Neighboring gene STARR-seq mESC enhancer starr_17928 Neighboring gene STARR-seq mESC enhancer starr_17929 Neighboring gene STARR-seq mESC enhancer starr_17930 Neighboring gene natural cytotoxicity triggering receptor 1 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E1718 Neighboring gene STARR-positive B cell enhancer ABC_E9682 Neighboring gene retinol dehydrogenase 13 (all-trans and 9-cis) Neighboring gene RIKEN cDNA D630041G03 gene Neighboring gene EPS8-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism. Lockyer S, et al. Thromb Res, 2006. PMID 16139873
  2. Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models. Jain S, et al. J Thromb Haemost, 2009 Oct. PMID 19624454
  3. Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria. Claushuis TAM, et al. Blood, 2018 Feb 22. PMID 29187378
  4. GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice. Gupta S, et al. Blood, 2018 Mar 8. PMID 29295843, Free PMC Article
  5. The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice. Cheli Y, et al. Blood, 2008 Feb 1. PMID 17991808, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target.
    Title: Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target.
  2. Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction.
    Title: Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction.
  3. A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury.
    Title: A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury.
  4. Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography.
    Title: Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography.
  5. Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability.
    Title: Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability.
  6. The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of beta-amyloid.
    Title: The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid.
  7. Platelet glycoprotein VI-dependent thrombus stabilization is essential for the intraportal engraftment of pancreatic islets.
    Title: Platelet glycoprotein VI-dependent thrombus stabilization is essential for the intraportal engraftment of pancreatic islets.
  8. Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3.
    Title: Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3.
  9. Our results show that, contrary to defects in coagulation, bleeding following a loss of vascular integrity caused by platelet CLEC-2 and GPVI deficiency facilitates wound repair by increasing fibrin(ogen) deposition, reducing inflammation, and promoting angiogenesis.
    Title: Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice.
  10. the truncated CD45 isoform regulates GPVI-mediated signaling and platelet functional responses by regulating SFK activation
    Title: Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables collagen receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within collagen-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within platelet aggregation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in platelet aggregation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in tetraspanin-enriched microdomain IEA
Inferred from Electronic Annotation
more info
  
located_in tetraspanin-enriched microdomain ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
platelet glycoprotein VI
Names
glycoprotein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163014.1 → NP_001156486.1  platelet glycoprotein VI precursor

    See identical proteins and their annotated locations for NP_001156486.1

    Status: VALIDATED

    Source sequence(s)
    AC137969
    Consensus CDS
    CCDS51972.1
    UniProtKB/Swiss-Prot
    E9QPN2, P0C191
    UniProtKB/TrEMBL
    B2RR15
    Related
    ENSMUSP00000145740.2, ENSMUST00000206928.2
    Conserved Domains (2) summary
    smart00410
    Location:34 → 96
    IG_like; Immunoglobulin like
    cl11960
    Location:27 → 109
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4365852..4400849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539910.4 → XP_006539973.1  platelet glycoprotein VI isoform X2

    Conserved Domains (1) summary
    cl11960
    Location:16 → 105
    Ig; Immunoglobulin domain

  2. XM_006539909.4 → XP_006539972.1  platelet glycoprotein VI isoform X1

    UniProtKB/TrEMBL
    A0A140T8Q7
    Conserved Domains (1) summary
    cl11960
    Location:114 → 203
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C191.2 GenPept UniProtKB/Swiss-Prot:P0C191

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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