Gja1 gap junction protein, alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24392, updated on 24-Apr-2024

Summary

Official Symbol: Gja1provided by RGD
Official Full Name: gap junction protein, alpha 1provided by RGD
Primary source: RGD:2690
See related: Ensembl:ENSRNOG00000000805 AllianceGenome:RGD:2690
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cx43; Cxnk1
Summary: Enables connexin binding activity; gap junction channel activity; and protein domain specific binding activity. Involved in several processes, including blood vessel diameter maintenance; negative regulation of cell population proliferation; and reproductive structure development. Located in several cellular components, including endosome; fascia adherens; and gap junction. Part of connexin complex. Used to study Parkinsonism; amnestic disorder; high grade glioma; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); autoimmune thyroiditis; borna disease; ischemia (multiple); and tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive craniometaphyseal dysplasia; congenital heart disease (multiple); erythrokeratodermia variabilis (multiple); oculodentodigital dysplasia; and palmoplantar keratoderma and congenital alopecia 1. Orthologous to human GJA1 (gap junction protein alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 726.0), Adrenal (RPKM 573.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (36302490..36315010)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (35756007..35768481)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (37876650..37889097)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Inhibition of connexin 43-mediated hemichannel activity promotes odontoblast differentiation of human dental pulp cells induced by lipopolysaccharide].
Title: [Inhibition of connexin 43-mediated hemichannel activity promotes odontoblast differentiation of human dental pulp cells induced by lipopolysaccharide].
Enriched environment alleviates neurological deficits via downregulation of Cx43 after experimental stroke.
Title: Enriched environment alleviates neurological deficits via downregulation of Cx43 after experimental stroke.
The potential roles of stress-induced phosphoprotein 1 and connexin 43 in rats with reperfusion arrhythmia.
Title: The potential roles of stress-induced phosphoprotein 1 and connexin 43 in rats with reperfusion arrhythmia.
MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction.
Title: MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction.
Cx43 Facilitates Mesenchymal Transition of Endothelial Cells Induced by Shear Stress.
Title: Cx43 Facilitates Mesenchymal Transition of Endothelial Cells Induced by Shear Stress.
Maladaptive plasticity induced by morphine is mediated by hippocampal astrocytic Connexin-43.
Title: Maladaptive plasticity induced by morphine is mediated by hippocampal astrocytic Connexin-43.
Inhibition of Connexin43 Improves the Recovery of Spinal Cord Injury Against Ferroptosis via the SLC7A11/GPX4 Pathway.
Title: Inhibition of Connexin43 Improves the Recovery of Spinal Cord Injury Against Ferroptosis via the SLC7A11/GPX4 Pathway.
Inhibition of Pyk2 Improves Cx43 Intercalated Disc Localization, Infarct Size, and Cardiac Function in Rats With Heart Failure.
Title: Inhibition of Pyk2 Improves Cx43 Intercalated Disc Localization, Infarct Size, and Cardiac Function in Rats With Heart Failure.
Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury.
Title: Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury.
Astrocytes in the spinal cord contributed to acute stress-induced gastric damage via the gap junction protein CX43.
Title: Astrocytes in the spinal cord contributed to acute stress-induced gastric damage via the gap junction protein CX43.

Submit: New GeneRIF Correction See all GeneRIFs (397)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC151788P1 (e-PCR)
- UniSTS:271174

D18Wox12 (e-PCR)
- UniSTS:239972

RH128006 (e-PCR)
- UniSTS:211315

RH135241 (e-PCR)
- UniSTS:218518

D18Wox13 (e-PCR)
- UniSTS:119225

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables SH3 domain binding	EXP Inferred from Experiment more info	PubMed
enables SH3 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables connexin binding	IPI Inferred from Physical Interaction more info	PubMed
enables disordered domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables gap junction channel activity	IDA Inferred from Direct Assay more info	PubMed
enables gap junction channel activity	ISO Inferred from Sequence Orthology more info
enables gap junction channel activity involved in cell communication by electrical coupling	ISO Inferred from Sequence Orthology more info
enables gap junction hemi-channel activity	ISO Inferred from Sequence Orthology more info
enables gap junction hemi-channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutathione transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ATP transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within atrial ventricular junction remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone development	ISO Inferred from Sequence Orthology more info
involved_in bone development	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in bone remodeling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cardiac conduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell communication by chemical coupling	ISO Inferred from Sequence Orthology more info
involved_in cell communication by electrical coupling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell communication by electrical coupling	ISO Inferred from Sequence Orthology more info
involved_in cell communication by electrical coupling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell junction organization	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to parathyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in chronic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within columnar/cuboidal epithelial cell maturation	ISO Inferred from Sequence Orthology more info
involved_in decidualization	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube development	ISO Inferred from Sequence Orthology more info
involved_in endothelium development	IEP Inferred from Expression Pattern more info	PubMed
involved_in epididymis development	IEP Inferred from Expression Pattern more info	PubMed
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in gap junction assembly	TAS Traceable Author Statement more info	PubMed
involved_in glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in glutathione transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart looping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in maintenance of protein localization in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based transport	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within milk ejection reflex	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gonadotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of trophoblast cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cell communication by chemical coupling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of establishment of Sertoli cell barrier	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mesodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of morphogenesis of an epithelium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of striated muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of atrial cardiac muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of bicellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell communication by electrical coupling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of heart contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fluid shear stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to pH	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vascular transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in Golgi-associated vesicle membrane	TAS Traceable Author Statement more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
part_of connexin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of connexin complex	IDA Inferred from Direct Assay more info	PubMed
part_of connexin complex	IEA Inferred from Electronic Annotation more info
part_of connexin complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of connexin complex	ISO Inferred from Sequence Orthology more info
located_in contractile muscle fiber	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in fascia adherens	IDA Inferred from Direct Assay more info	PubMed
located_in fascia adherens	ISO Inferred from Sequence Orthology more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gap junction alpha-1 protein

Names: connexin 43; connexin k1; gap junction 43 kDa heart protein; gap junction membrane channel protein alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429427.1 → NP_001416356.1 gap junction alpha-1 protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020
NM_001429428.1 → NP_001416357.1 gap junction alpha-1 protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020
NM_001429429.1 → NP_001416358.1 gap junction alpha-1 protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020
NM_012567.3 → NP_036699.1 gap junction alpha-1 protein

See identical proteins and their annotated locations for NP_036699.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

P08050, Q53ZE1

UniProtKB/TrEMBL

A0A654ICE6, A0A8L2UHE4

Related

ENSRNOP00000093256.1, ENSRNOT00000100494.1

Conserved Domains (2) summary

pfam00029
Location:3 → 233

Connexin

pfam03508
Location:293 → 312

Connexin43; Gap junction alpha-1 protein (Cx43)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

36302490..36315010

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098413.2 → XP_038954341.1 gap junction alpha-1 protein isoform X1

UniProtKB/Swiss-Prot

P08050, Q53ZE1

UniProtKB/TrEMBL

A0A654ICE6, A0A8L2UHE4

Conserved Domains (2) summary

pfam00029
Location:3 → 233

Connexin

pfam03508
Location:293 → 312

Connexin43; Gap junction alpha-1 protein (Cx43)
XM_063278953.1 → XP_063135023.1 gap junction alpha-1 protein isoform X1

UniProtKB/Swiss-Prot

P08050, Q53ZE1

UniProtKB/TrEMBL

A0A654ICE6
XM_063278954.1 → XP_063135024.1 gap junction alpha-1 protein isoform X1

UniProtKB/Swiss-Prot

P08050, Q53ZE1

UniProtKB/TrEMBL

A0A654ICE6