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Zfp771 zinc finger protein 771 [ Mus musculus (house mouse) ]

Gene ID: 244216, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp771provided by MGI
Official Full Name
zinc finger protein 771provided by MGI
Primary source
MGI:MGI:2442050
See related
Ensembl:ENSMUSG00000054716 AllianceGenome:MGI:2442050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf771; G630024C07Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZNF771 (zinc finger protein 771). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 158.9), adrenal adult (RPKM 143.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp771 in Genome Data Viewer
Location:
7 F3; 7 69.41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126842168..126854044)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127242996..127254872)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene septin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134361531-134361732 Neighboring gene STARR-seq mESC enhancer starr_20173 Neighboring gene STARR-seq mESC enhancer starr_20176 Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553 Neighboring gene STARR-seq mESC enhancer starr_20179 Neighboring gene STARR-positive B cell enhancer ABC_E6605 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134404258-134404441 Neighboring gene dCTP pyrophosphatase 1 Neighboring gene selenophosphate synthetase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2. Lv X, et al. Acta Pharm Sin B, 2023 Apr. PMID 37139431, Free PMC Article
  2. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 771
Names
mesenchymal stem cell protein DSC43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360916.1 → NP_001347845.1  zinc finger protein 771 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA030159, AC133494
    Conserved Domains (3) summary
    COG5048
    Location:39 → 194
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:14 → 34
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:194 → 218
    zf-H2C2_2; Zinc-finger double domain

  2. NM_177362.4 → NP_796336.1  zinc finger protein 771 isoform 1

    See identical proteins and their annotated locations for NP_796336.1

    Status: VALIDATED

    Source sequence(s)
    AC133494, AK090240
    Consensus CDS
    CCDS21861.1
    UniProtKB/Swiss-Prot
    B2RSX6, Q6P5I0, Q8BJ90
    Related
    ENSMUSP00000056959.4, ENSMUST00000052509.6
    Conserved Domains (3) summary
    COG5048
    Location:90 → 245
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:65 → 85
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:245 → 269
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126842168..126854044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507843.3 → XP_006507906.1  zinc finger protein 771 isoform X1

    See identical proteins and their annotated locations for XP_006507906.1

    UniProtKB/Swiss-Prot
    B2RSX6, Q6P5I0, Q8BJ90
    Conserved Domains (3) summary
    COG5048
    Location:90 → 245
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:65 → 85
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:245 → 269
    zf-H2C2_2; Zinc-finger double domain

  2. XM_030242585.1 → XP_030098445.1  zinc finger protein 771 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:39 → 194
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:14 → 34
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:194 → 218
    zf-H2C2_2; Zinc-finger double domain

  3. XM_030242586.1 → XP_030098446.1  zinc finger protein 771 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:39 → 194
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:14 → 34
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:194 → 218
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJ90.1 GenPept UniProtKB/Swiss-Prot:Q8BJ90

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