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Kat6a K(lysine) acetyltransferase 6A [ Mus musculus (house mouse) ]

Gene ID: 244349, updated on 12-Nov-2024

Summary

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Official Symbol
Kat6aprovided by MGI
Official Full Name
K(lysine) acetyltransferase 6Aprovided by MGI
Primary source
MGI:MGI:2442415
See related
Ensembl:ENSMUSG00000031540 AllianceGenome:MGI:2442415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MOZ; Myst3; Zfp220; 1500036M03; 9930021N24Rik
Summary
Enables chromatin binding activity and histone H3K9 acetyltransferase activity. Acts upstream of or within several processes, including circulatory system development; face morphogenesis; and negative regulation of DNA-binding transcription factor activity. Located in nucleus. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; and liver. Used to study DiGeorge syndrome. Human ortholog(s) of this gene implicated in Arboleda-Tham syndrome and acute myeloid leukemia. Orthologous to human KAT6A (lysine acetyltransferase 6A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 13.7), CNS E11.5 (RPKM 10.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Kat6a in Genome Data Viewer
Location:
8 A2; 8 11.42 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23349458..23433275)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22859442..22943259)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700041G16 gene Neighboring gene STARR-positive B cell enhancer ABC_E188 Neighboring gene STARR-positive B cell enhancer ABC_E8844 Neighboring gene STARR-positive B cell enhancer ABC_E2859 Neighboring gene STARR-positive B cell enhancer ABC_E6627 Neighboring gene STARR-positive B cell enhancer ABC_E2259 Neighboring gene STARR-seq mESC enhancer starr_20912 Neighboring gene adaptor-related protein complex 3, mu 2 subunit Neighboring gene predicted gene, 46036 Neighboring gene predicted gene, 24735 Neighboring gene mitochondrial ribosomal protein L4 pseudogene Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene ankyrin 1, erythroid Neighboring gene predicted gene 15816 Neighboring gene microRNA 3107 Neighboring gene microRNA 486

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway. Sheikh BN, et al. Oncogene, 2015 Nov 19. PMID 25772242
  2. MOZ is critical for the development of MOZ/MLL fusion-induced leukemia through regulation of Hoxa9/Meis1 expression. Katsumoto T, et al. Blood Adv, 2022 Oct 11. PMID 35947126, Free PMC Article
  3. Genetic modifier to chromatin may contribute to 22q11 deletion/VCF/DiGeorge syndrome variability: MOZ gene may also exacerbate effects of retinoic acid in genetic disorder. Levenson D. Am J Med Genet A, 2012 Dec. PMID 23174944
  4. The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors. Perez-Campo FM, et al. Blood, 2009 May 14. PMID 19264921, Free PMC Article
  5. MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells. Sheikh BN, et al. Blood, 2016 Nov 10. PMID 27663673

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3.
    Title: KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3.
  2. Lysine acetyltransferase 6A maintains CD4[+] T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity.
    Title: Lysine acetyltransferase 6A maintains CD4(+) T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity.
  3. MOZ is critical for the development of MOZ/MLL fusion-induced leukemia through regulation of Hoxa9/Meis1 expression.
    Title: MOZ is critical for the development of MOZ/MLL fusion-induced leukemia through regulation of Hoxa9/Meis1 expression.
  4. Identification of a specific program by which the chromatin modifier MOZ regulates craniofacial development.
    Title: MOZ directs the distal-less homeobox gene expression program during craniofacial development.
  5. Loss of MOZ in adult mice leads to the rapid loss of hematopoietic stem cells as defined by transplantation.
    Title: MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells.
  6. Our work revealed that MOZ and BMI1 regulate HSCs in a synergistic manner by acting on distinct processes required to maintain HSCs.
    Title: MOZ and BMI1 act synergistically to maintain hematopoietic stem cells.
  7. BRPF2-MOZ complexes play an important role in the differentiation of embryonic stem cells via H3K14 acetylation.
    Title: The BRPF2/BRD1-MOZ complex is involved in retinoic acid-induced differentiation of embryonic stem cells.
  8. the expression of MOZ-TIF2 fusion protein represses the transcription of p16INK4a and p19ARF and blocks senescence.
    Title: Expression of the MOZ-TIF2 oncoprotein in mice represses senescence.
  9. Study establishes that MOZ is an upstream inhibitor of the INK4A-ARF pathway, and suggests that inhibiting MOZ may be one way to induce senescence in proliferative tumor cells.
    Title: MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway.
  10. these data suggest that the molecular pathogenesis of ventricular septal defectss in Moz germline mutant mice is due to loss of MOZ-dependant activation of mesodermal Tbx1 and Tbx5 expression.
    Title: Mesodermal expression of Moz is necessary for cardiac septum development.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K14 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3K9 acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K16 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K5 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aorta morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within face morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within face morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in myeloid cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in protein acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein acetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of developmental process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of hemopoiesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MOZ/MORF histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of MOZ/MORF histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
histone acetyltransferase KAT6A
Names
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3
MYST histone acetyltransferase (monocytic leukemia) 3
histone acetyltransferase MYST3
monocytic leukemia zinc finger homolog
monocytic leukemia zinc finger protein
zinc finger protein 220
NP_001074618.1
NP_001351378.1
XP_006509176.1
XP_017168283.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081149.2 → NP_001074618.1  histone acetyltransferase KAT6A

    See identical proteins and their annotated locations for NP_001074618.1

    Status: VALIDATED

    Source sequence(s)
    AC115361, AC142414
    Consensus CDS
    CCDS40294.1
    UniProtKB/Swiss-Prot
    Q8BW52, Q8BYH1, Q8BZ21, Q8C1F3
    UniProtKB/TrEMBL
    G3X940
    Related
    ENSMUSP00000038181.7, ENSMUST00000044331.7
    Conserved Domains (4) summary
    smart00526
    Location:85 → 162
    H15; Domain in histone families 1 and 5
    cd15527
    Location:264 → 310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205 → 262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cl27485
    Location:503 → 777
    MOZ_SAS; MOZ/SAS family

  2. NM_001364449.1 → NP_001351378.1  histone acetyltransferase KAT6A

    Status: VALIDATED

    Source sequence(s)
    AC115361, AK132474
    Consensus CDS
    CCDS40294.1
    UniProtKB/Swiss-Prot
    Q8BW52, Q8BYH1, Q8BZ21, Q8C1F3
    UniProtKB/TrEMBL
    G3X940
    Related
    ENSMUSP00000106324.2, ENSMUST00000110696.8
    Conserved Domains (4) summary
    smart00526
    Location:85 → 162
    H15; Domain in histone families 1 and 5
    cd15527
    Location:264 → 310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205 → 262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cl27485
    Location:503 → 777
    MOZ_SAS; MOZ/SAS family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    23349458..23433275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509113.2 → XP_006509176.1  histone acetyltransferase KAT6A isoform X1

    UniProtKB/Swiss-Prot
    Q8BW52, Q8BYH1, Q8BZ21, Q8C1F3
    Conserved Domains (4) summary
    smart00526
    Location:85 → 162
    H15; Domain in histone families 1 and 5
    PLN00104
    Location:496 → 770
    PLN00104; MYST -like histone acetyltransferase; Provisional
    cd15527
    Location:264 → 310
    PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    cd15618
    Location:205 → 262
    PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

  2. XM_017312794.2 → XP_017168283.1  histone acetyltransferase KAT6A isoform X2

    Conserved Domains (1) summary
    PLN00104
    Location:68 → 342
    PLN00104; MYST -like histone acetyltransferase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZ21.2 GenPept UniProtKB/Swiss-Prot:Q8BZ21

Gene LinkOut

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