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Mrap2 melanocortin 2 receptor accessory protein 2 [ Mus musculus (house mouse) ]

Gene ID: 244958, updated on 2-Nov-2024

Summary

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Official Symbol
Mrap2provided by MGI
Official Full Name
melanocortin 2 receptor accessory protein 2provided by MGI
Primary source
MGI:MGI:3609239
See related
Ensembl:ENSMUSG00000042761 AllianceGenome:MGI:3609239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables signaling receptor regulator activity and type 4 melanocortin receptor binding activity. Involved in energy homeostasis; energy reserve metabolic process; and feeding behavior. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Orthologous to human MRAP2 (melanocortin 2 receptor accessory protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 1.9), frontal lobe adult (RPKM 0.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Mrap2 in Genome Data Viewer
Location:
9 E3.1; 9 46.76 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (87026293..87066104)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (87144236..87184051)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6782 Neighboring gene predicted gene, 57850 Neighboring gene cytochrome b5 reductase 4 Neighboring gene predicted gene 8282 Neighboring gene centrosomal protein 162 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:87150069-87150178 Neighboring gene STARR-seq mESC enhancer starr_24844 Neighboring gene predicted gene, 51416 Neighboring gene predicted gene 9540

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Arginine 125 Is an Essential Residue for the Function of MRAP2. Fullone MR, et al. Int J Mol Sci, 2022 Aug 30. PMID 36077245, Free PMC Article
  2. Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer. Wang M, et al. Front Endocrinol (Lausanne), 2021. PMID 34759891, Free PMC Article
  3. Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure. Bruschetta G, et al. Mol Metab, 2018 Dec. PMID 30352741, Free PMC Article
  4. Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol. Novoselova TV, et al. J Endocrinol, 2016 Jul. PMID 27106110, Free PMC Article
  5. MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R. Bernard A, et al. JCI Insight, 2023 Jan 24. PMID 36692018, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arginine 125 Is an Essential Residue for the Function of MRAP2.
    Title: Arginine 125 Is an Essential Residue for the Function of MRAP2.
  2. Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer.
    Title: Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer.
  3. MRAP2 in paraventricular MC4R neurons controls energy intake and expenditure.
    Title: Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure.
  4. MRAP2 is an important modulator of the energy homeostasis machinery that operates through the regulation of multiple GPCRs throughout the hypothalamus.
    Title: MRAP2 regulates ghrelin receptor signaling and hunger sensing.
  5. Mrap2 KO mice have a significant increase in body weight, with increased fat and lean mass, but without detectable changes in food intake or energy expenditure. Transcriptomic analysis showed significantly decreased expression of Sim1, Trh, Oxt and Crh within the paraventricular nucleus of Mrap2 KO mice. Circulating levels of both high-density and low-density lipoprotein were increased in Mrap2 KO mice.
    Title: Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol.
  6. show that MRAP2 significantly and specifically inhibits PKR1 signaling.
    Title: The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1.
  7. Mrap2 interacts directly with melanocortin 4 receptor (Mc4r), a protein previously implicated in mammalian obesity, and it enhances Mc4r-mediated generation of the second messenger cyclic adenosine monophosphate, suggesting that alterations in Mc4r signaling may be one mechanism underlying the association between Mrap2 disruption and obesity.
    Title: Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity.
  8. The data suggest that MRAPalpha is involved in MC2R targeting to the plasma membrane, while MRAPbeta may enhance ACTH-MC2R coupling to cAMP production.
    Title: The C-terminal domains of melanocortin-2 receptor (MC2R) accessory proteins (MRAP1) influence their localization and ACTH-induced cAMP production.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (5)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables corticotropin hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables corticotropin hormone receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables corticotropin hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables type 1 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 1 melanocortin receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables type 1 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables type 3 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 3 melanocortin receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables type 3 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables type 4 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 4 melanocortin receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables type 4 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables type 5 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 5 melanocortin receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables type 5 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in energy reserve metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
melanocortin-2 receptor accessory protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101482.2 → NP_001094952.2  melanocortin-2 receptor accessory protein 2

    See identical proteins and their annotated locations for NP_001094952.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.
    Source sequence(s)
    AC125370, AC168882, BQ175739
    Consensus CDS
    CCDS52878.1
    UniProtKB/Swiss-Prot
    D3YVA7, D3YZ75, D3Z1Q2, D3Z746
    Related
    ENSMUSP00000046271.8, ENSMUST00000049457.14
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family

  2. NM_001177731.1 → NP_001171202.1  melanocortin-2 receptor accessory protein 2

    See identical proteins and their annotated locations for NP_001171202.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 through 3 encode the same protein.
    Source sequence(s)
    AC125370, AC168882, BQ175739, CJ059941
    Consensus CDS
    CCDS52878.1
    UniProtKB/Swiss-Prot
    D3YVA7, D3YZ75, D3Z1Q2, D3Z746
    Related
    ENSMUSP00000135904.2, ENSMUST00000179313.3
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family

  3. NM_001359955.1 → NP_001346884.1  melanocortin-2 receptor accessory protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.
    Source sequence(s)
    AC125370, AC168882, BQ175739
    Consensus CDS
    CCDS52878.1
    UniProtKB/Swiss-Prot
    D3YVA7, D3YZ75, D3Z1Q2, D3Z746
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family

  4. NM_001421369.1 → NP_001408298.1  melanocortin-2 receptor accessory protein 2

    Status: VALIDATED

    Source sequence(s)
    AC125370, AC168882
    UniProtKB/Swiss-Prot
    D3YVA7, D3YZ75, D3Z1Q2, D3Z746

  5. NM_001421370.1 → NP_001408299.1  melanocortin-2 receptor accessory protein 2

    Status: VALIDATED

    Source sequence(s)
    AC125370, AC168882
    UniProtKB/Swiss-Prot
    D3YVA7, D3YZ75, D3Z1Q2, D3Z746

  6. NM_001421371.1 → NP_001408300.1  melanocortin-2 receptor accessory protein 2

    Status: VALIDATED

    Source sequence(s)
    AC125370, AC168882
    UniProtKB/Swiss-Prot
    D3YVA7, D3YZ75, D3Z1Q2, D3Z746

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    87026293..87066104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511176.4 → XP_006511239.1  melanocortin-2 receptor accessory protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006511239.1

    UniProtKB/Swiss-Prot
    D3YVA7, D3YZ75, D3Z1Q2, D3Z746
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family

  2. XM_006511179.4 → XP_006511242.1  melanocortin-2 receptor accessory protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006511242.1

    UniProtKB/Swiss-Prot
    D3YVA7, D3YZ75, D3Z1Q2, D3Z746
    Related
    ENSMUSP00000108774.2, ENSMUST00000113149.8
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family

  3. XM_030244385.2 → XP_030100245.1  melanocortin-2 receptor accessory protein 2 isoform X1

    UniProtKB/Swiss-Prot
    D3YVA7, D3YZ75, D3Z1Q2, D3Z746
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family

  4. XM_006511177.5 → XP_006511240.1  melanocortin-2 receptor accessory protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006511240.1

    UniProtKB/Swiss-Prot
    D3YVA7, D3YZ75, D3Z1Q2, D3Z746
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family

  5. XM_036155010.1 → XP_036010903.1  melanocortin-2 receptor accessory protein 2 isoform X1

    UniProtKB/Swiss-Prot
    D3YVA7, D3YZ75, D3Z1Q2, D3Z746
    Conserved Domains (1) summary
    pfam15183
    Location:16 → 101
    MRAP; Melanocortin-2 receptor accessory protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3Z1Q2.2 GenPept UniProtKB/Swiss-Prot:D3Z1Q2

Gene LinkOut

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