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Tmem255a transmembrane protein 255A [ Mus musculus (house mouse) ]

Gene ID: 245386, updated on 30-Apr-2024

Summary

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Official Symbol
Tmem255aprovided by MGI
Official Full Name
transmembrane protein 255Aprovided by MGI
Primary source
MGI:MGI:3045722
See related
Ensembl:ENSMUSG00000036502 AllianceGenome:MGI:3045722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam70a; 4933417N17; 6430550H21Rik
Summary
Acts upstream of or within response to bacterium. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including genitourinary system. Orthologous to human TMEM255A (transmembrane protein 255A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 10.3), frontal lobe adult (RPKM 9.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem255a in Genome Data Viewer
Location:
X A3.3; X 22.46 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (37285450..37341373, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (38196573..38252496, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39506 Neighboring gene reproductive homeobox 13 Neighboring gene STARR-seq mESC enhancer starr_47013 Neighboring gene STARR-seq mESC enhancer starr_47014 Neighboring gene zinc finger protein 36, C3H type-like 1, pseudogene Neighboring gene zinc finger and BTB domain containing 33 Neighboring gene STARR-seq mESC enhancer starr_47015 Neighboring gene microRNA 3110 Neighboring gene predicted gene, 39507 Neighboring gene arylsulfatase K pseudogene Neighboring gene reproductive homeobox 7, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fam70A binds Wnt5a to regulate meiosis and quality of mouse oocytes. Zhang NN, et al. Cell Prolif, 2020 Jun. PMID 32391621, Free PMC Article
  2. Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles. Dong B, et al. Development, 2018 Oct 8. PMID 30237242, Free PMC Article
  3. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Takase H, et al. Blood, 2012 Jul 26. PMID 22535667
  4. Genomewide discovery and classification of candidate ovarian fertility genes in the mouse. Gallardo TD, et al. Genetics, 2007 Sep. PMID 17660561, Free PMC Article
  5. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fam70A regulates meiosis and quality of mouse oocytes through both canonical and non-canonical Wnt5a signalling pathways.
    Title: Fam70A binds Wnt5a to regulate meiosis and quality of mouse oocytes.
  2. Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
    Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 255A
Names
family with sequence similarity 70, member A
protein FAM70A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289727.1 → NP_001276656.1  transmembrane protein 255A isoform 2

    See identical proteins and their annotated locations for NP_001276656.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 3' terminal exon, which causes a frameshift, compared to variant 1. This results in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK041985, AL512346, BY085502
    Consensus CDS
    CCDS81122.1
    UniProtKB/Swiss-Prot
    Q8BHW5
    Related
    ENSMUSP00000086457.4, ENSMUST00000089056.10
    Conserved Domains (2) summary
    pfam13273
    Location:30 → 105
    DUF4064; Protein of unknown function (DUF4064)
    pfam14967
    Location:9 → 297
    FAM70; FAM70 protein

  2. NM_001289728.1 → NP_001276657.1  transmembrane protein 255A isoform 3

    See identical proteins and their annotated locations for NP_001276657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AK045375, AK078264, AV362114, BC062956, BY085502
    Consensus CDS
    CCDS72367.1
    UniProtKB/Swiss-Prot
    Q8BHW5
    UniProtKB/TrEMBL
    Q8BHS0
    Related
    ENSMUSP00000086455.5, ENSMUST00000089054.11
    Conserved Domains (1) summary
    pfam14967
    Location:7 → 327
    FAM70; FAM70 protein

  3. NM_172930.4 → NP_766518.3  transmembrane protein 255A isoform 1

    See identical proteins and their annotated locations for NP_766518.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK045375, AV362114, BC062956, BY085502
    Consensus CDS
    CCDS30089.1
    UniProtKB/Swiss-Prot
    Q6P5C9, Q8BHV8, Q8BHW5, Q8BHZ6
    Related
    ENSMUSP00000064511.8, ENSMUST00000066498.8
    Conserved Domains (1) summary
    pfam14967
    Location:9 → 350
    FAM70; FAM70 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    37285450..37341373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541495.4 → XP_006541558.1  transmembrane protein 255A isoform X1

    Related
    ENSMUST00000155848.8
    Conserved Domains (1) summary
    pfam14967
    Location:7 → 303
    FAM70; FAM70 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHW5.1 GenPept UniProtKB/Swiss-Prot:Q8BHW5

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