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Wasf3 WASP family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 245880, updated on 2-Nov-2024

Summary

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Official Symbol
Wasf3provided by MGI
Official Full Name
WASP family, member 3provided by MGI
Primary source
MGI:MGI:2658986
See related
Ensembl:ENSMUSG00000029636 AllianceGenome:MGI:2658986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Scar3; Wave3
Summary
Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Involved in modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium assembly; oligodendrocyte development; and positive regulation of myelination. Located in glial cell projection and lamellipodium. Is active in glutamatergic synapse and postsynapse. Is expressed in adrenal gland; cap mesenchyme; nervous system; and neural retina. Orthologous to human WASF3 (WASP family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 17.1), frontal lobe adult (RPKM 16.1) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Wasf3 in Genome Data Viewer
Location:
5 G3; 5 85.23 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146317411..146410425)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146385006..146473615)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52832 Neighboring gene predicted gene, 38747 Neighboring gene STARR-seq mESC enhancer starr_14840 Neighboring gene STARR-seq mESC enhancer starr_14845 Neighboring gene predicted gene 6408 Neighboring gene predicted gene 6370

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer. Kansakar U, et al. Sci Rep, 2021 Feb 16. PMID 33594155, Free PMC Article
  2. PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation. Corral-Serrano JC, et al. Proc Natl Acad Sci U S A, 2020 May 5. PMID 32312818, Free PMC Article
  3. Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer. Qin H, et al. Am J Pathol, 2019 Dec. PMID 31542393
  4. WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma. Sossey-Alaoui K, et al. Oncogene, 2002 Aug 29. PMID 12185600
  5. Characterization of the WAVE1 knock-out mouse: implications for CNS development. Dahl JP, et al. J Neurosci, 2003 Apr 15. PMID 12716942, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer.
    Title: Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer.
  2. our work suggests that PCARE is an actin-associated protein that interacts with WASF3 to regulate the actin-driven expansion of the ciliary membrane at the initiation of new outer segment disk formation.
    Title: PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation.
  3. Elevated WASF3 Expression Promotes Metastasis in Breast Cancer.
    Title: Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer.
  4. p63alpha protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion
    Title: p63α protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion.
  5. WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization.
    Title: WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modification of postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modification of postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of myelination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in glial cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
actin-binding protein WASF3
Names
WAS protein family, member 3
WASP family protein member 3
protein WAVE-3
wiskott-Aldrich syndrome protein family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418239.1 → NP_001405168.1  actin-binding protein WASF3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC093356, AC115019
    UniProtKB/Swiss-Prot
    Q8VHI6

  2. NM_001418240.1 → NP_001405169.1  actin-binding protein WASF3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC093356, AC115019
    UniProtKB/Swiss-Prot
    Q8VHI6

  3. NM_001418241.1 → NP_001405170.1  actin-binding protein WASF3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC093356, AC115019
    UniProtKB/Swiss-Prot
    Q8VHI6

  4. NM_001418242.1 → NP_001405171.1  actin-binding protein WASF3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC093356, AC115019

  5. NM_145155.4 → NP_660137.1  actin-binding protein WASF3 isoform a

    See identical proteins and their annotated locations for NP_660137.1

    Status: VALIDATED

    Source sequence(s)
    AC093356, AC115019
    Consensus CDS
    CCDS19870.1
    UniProtKB/Swiss-Prot
    Q8VHI6
    UniProtKB/TrEMBL
    Q3V386
    Related
    ENSMUSP00000016143.8, ENSMUST00000016143.9
    Conserved Domains (1) summary
    smart00246
    Location:439 → 456
    WH2; Wiskott Aldrich syndrome homology region 2

RNA

  1. NR_184697.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093356, AC115019

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    146317411..146410425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504833.5 → XP_006504896.1  actin-binding protein WASF3 isoform X1

    See identical proteins and their annotated locations for XP_006504896.1

    UniProtKB/Swiss-Prot
    Q8VHI6
    UniProtKB/TrEMBL
    Q3V386
    Conserved Domains (1) summary
    smart00246
    Location:439 → 456
    WH2; Wiskott Aldrich syndrome homology region 2

  2. XM_030254506.2 → XP_030110366.1  actin-binding protein WASF3 isoform X3

    Conserved Domains (1) summary
    smart00246
    Location:227 → 244
    WH2; Wiskott Aldrich syndrome homology region 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHI6.1 GenPept UniProtKB/Swiss-Prot:Q8VHI6

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