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Npr1 natriuretic peptide receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24603, updated on 2-Nov-2024

Summary

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Official Symbol
Npr1provided by RGD
Official Full Name
natriuretic peptide receptor 1provided by RGD
Primary source
RGD:3195
See related
EnsemblRapid:ENSRNOG00000014684 AllianceGenome:RGD:3195
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gca; Npra; Anpra; NPR-A
Summary
Enables guanylate cyclase activity. Involved in several processes, including cGMP-mediated signaling; positive regulation of cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 223.9), Lung (RPKM 119.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Npr1 in Genome Data Viewer
Location:
2q34
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (178231766..178247591, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175934181..175950118, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189840403..189857032, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene oligosaccharyltransferase complex non-catalytic subunit like 1 Neighboring gene uncharacterized LOC120101091 Neighboring gene transfer RNA methionine (anticodon CAU) 1 Neighboring gene interleukin enhancer binding factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of dehydration-induced water intake by glucocorticoids is associated with activation of hypothalamic natriuretic peptide receptor-A in rat. Liu C, et al. PLoS One, 2010 Dec 20. PMID 21187974, Free PMC Article
  2. Inhibitory effect of Ca(2+) on ATP-mediated stimulation of NPR-A-coupled guanylyl cyclase in renal glomeruli from spontaneously hypertensive and normotensive rats. Woodard GE, et al. J Physiol Pharmacol, 2006 Sep. PMID 17033090
  3. Atrial natriuretic factor stimulates renal dopamine uptake mediated by natriuretic peptide-type A receptor. Fernández BE, et al. Regul Pept, 2005 Jan 15. PMID 15544851
  4. Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells. Chen S, et al. Kidney Int, 2007 Aug. PMID 17440494
  5. Characterization of a cGMP-response element in the guanylyl cyclase/natriuretic peptide receptor A gene promoter. Hum D, et al. Hypertension, 2004 Jun. PMID 15096467

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for natriuretic peptide receptor-A) transcription in H9c2 cells: involvement of beta-AR-ROS signaling.
    Title: Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for natriuretic peptide receptor-A) transcription in H9c2 cells: involvement of β-AR-ROS signaling.
  2. Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide.
    Title: Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide.
  3. Atenolol treatment normalized the altered expression of Npr1 and Npr2 genes.
    Title: Differential expression and regulation of anti-hypertrophic genes Npr1 and Npr2 during β-adrenergic receptor activation-induced hypertrophic growth in rats.
  4. Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in cardiomyocytes in vitro.
    Title: Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in vitro.
  5. The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis.
    Title: Transforming growth factor β1 antagonizes the transcription, expression and vascular signaling of guanylyl cyclase/natriuretic peptide receptor A - role of δEF1.
  6. augmentation of inhibitory effect on basal motility by ANP in experimental colitis may be due an increased expression of colonic natriuretic peptide receptor-A mRNA
    Title: Modulation in Natriuretic Peptides System in Experimental Colitis in Rats.
  7. Provide direct evidence for the presence and synthesis of ANP and its receptors in both neuronal and non-neuronal cells within the cochlear spiral ganglion.
    Title: Expression patterns of atrial natriuretic peptide and its receptors within the cochlear spiral ganglion of the postnatal rat.
  8. Angiotensin-II down-regulates cardiac natriuretic peptide receptor-A mediated anti-hypertrophic signaling in experimental rat hearts
    Title: Angiotensin-II down-regulates cardiac natriuretic peptide receptor-A mediated anti-hypertrophic signaling in experimental rat hearts.
  9. BNP and NPR-A are expressed in the dorsal horn ganglion, and expressions are elevated in rats with chronic nonbacterial prostatitis.
    Title: [Expressions of BNP and NPR-A in rat models of chronic nonbacterial prostatitis and their significance].
  10. knockdown of NPR-A up-regulates the expression of NPR-C, Gialpha proteins, and NPR-C-linked adenylyl cyclase signalling and suggests a cross-talk between NPR-A and NPR-C.
    Title: Knockdown of natriuretic peptide receptor-A enhances receptor C expression and signalling in vascular smooth muscle cells.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables natriuretic peptide receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood vessel diameter maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor guanylyl cyclase signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in receptor guanylyl cyclase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
atrial natriuretic peptide receptor 1
Names
ANP-A
ANPR-A
GC-A
atrial natriuretic peptide A-type receptor
atrial natriuretic peptide receptor A
atrial natriuretic peptide receptor type A
guanylate cyclase A
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
NP_036745.1
XP_006232653.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012613.1 → NP_036745.1  atrial natriuretic peptide receptor 1 precursor

    See identical proteins and their annotated locations for NP_036745.1

    Status: PROVISIONAL

    Source sequence(s)
    J05677
    UniProtKB/Swiss-Prot
    A1A5N8, P18910
    UniProtKB/TrEMBL
    A0A8I5ZSQ4, A6J6M1
    Related
    ENSRNOP00000020307.3, ENSRNOT00000020307.5
    Conserved Domains (7) summary
    cd06385
    Location:32 → 439
    PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor
    smart00219
    Location:543 → 797
    TyrKc; Tyrosine kinase, catalytic domain
    smart00044
    Location:836 → 1025
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:530 → 803
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:863 → 1049
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:50 → 410
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:812 → 857
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    178231766..178247591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232591.5 → XP_006232653.1  atrial natriuretic peptide receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006232653.1

    UniProtKB/Swiss-Prot
    A1A5N8, P18910
    UniProtKB/TrEMBL
    A0A8I5ZSQ4, A6J6M1
    Conserved Domains (7) summary
    cd06385
    Location:32 → 439
    PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor
    smart00219
    Location:543 → 797
    TyrKc; Tyrosine kinase, catalytic domain
    smart00044
    Location:836 → 1025
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:530 → 803
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:863 → 1049
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:50 → 410
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:812 → 857
    HNOBA; Heme NO binding associated

RNA

  1. XR_005500239.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18910.1 GenPept UniProtKB/Swiss-Prot:P18910

Gene LinkOut

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