U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Calcoco1 calcium binding and coiled coil domain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246047, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Symbol
Calcoco1provided by RGD
Full Name
calcium binding and coiled coil domain 1provided by RGD
Primary source
RGD:619812
See related
EnsemblRapid:ENSRNOG00000015447 AllianceGenome:RGD:619812
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including armadillo repeat domain binding activity; beta-catenin binding activity; and nuclear receptor coactivator activity. Predicted to be involved in intracellular steroid hormone receptor signaling pathway; positive regulation of gene expression; and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nucleus. Orthologous to human CALCOCO1 (calcium binding and coiled-coil domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 204.6), Thymus (RPKM 160.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Calcoco1 in Genome Data Viewer
Location:
7q36
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135713208..135728044, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133834705..133849515, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144307562..144322253, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene activating transcription factor 7 Neighboring gene uncharacterized LOC120093744 Neighboring gene ATP synthase membrane subunit c locus 2 Neighboring gene chondrogenesis-associated transcript Neighboring gene tubulin cofactor A like 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Kim JH, et al. Mol Cell, 2003 Dec. PMID 14690606
  2. Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor-mediated transcription. Kim JH, et al. J Biol Chem, 2004 Nov 26. PMID 15383530
  3. Cellular signaling mediated by calphoglin-induced activation of IPP and PGM. Takahashi K, et al. Biochem Biophys Res Commun, 2004 Dec 3. PMID 15522220
  4. CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function. Mizuta S, et al. Genes Cells, 2014 Jan. PMID 24245781, Free PMC Article
  5. Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1. Yang CK, et al. J Biol Chem, 2006 Feb 10. PMID 16344550, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA1536, MGC93160

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in nuclear receptor-mediated steroid hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear receptor-mediated steroid hormone signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
calcium-binding and coiled-coil domain-containing protein 1
Names
calcium-binding and coiled-coil domain-containing protein 1-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139190.2 → NP_631929.2  calcium-binding and coiled-coil domain-containing protein 1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q66HR5, Q8R443
    UniProtKB/TrEMBL
    A0A8L2QVZ6, A6KCX8
    Related
    ENSRNOP00000021522.3, ENSRNOT00000021523.8
    Conserved Domains (3) summary
    pfam07888
    Location:122 → 584
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    pfam17751
    Location:15 → 118
    SKICH; SKICH domain
    cd21967
    Location:654 → 682
    Zn-C2H2_CALCOCO1; C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    135713208..135728044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262991.1 → XP_063119061.1  calcium-binding and coiled-coil domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q66HR5, Q8R443
    UniProtKB/TrEMBL
    A6KCX8

  2. XM_039078406.2 → XP_038934334.1  calcium-binding and coiled-coil domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0S1, A0A8L2QVZ6
    Related
    ENSRNOP00000071559.1, ENSRNOT00000089290.3
    Conserved Domains (3) summary
    pfam07888
    Location:122 → 584
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    pfam17751
    Location:15 → 118
    SKICH; SKICH domain
    cd21967
    Location:678 → 706
    Zn-C2H2_CALCOCO1; C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) and similar proteins

  3. XM_063262990.1 → XP_063119060.1  calcium-binding and coiled-coil domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0S1

  4. XM_063262992.1 → XP_063119062.1  calcium-binding and coiled-coil domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q66HR5, Q8R443
    UniProtKB/TrEMBL
    A6KCX8

  5. XM_039078407.2 → XP_038934335.1  calcium-binding and coiled-coil domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0S1, A0A8L2QVZ6
    Conserved Domains (3) summary
    pfam07888
    Location:122 → 584
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
    pfam17751
    Location:15 → 118
    SKICH; SKICH domain
    cd21967
    Location:678 → 706
    Zn-C2H2_CALCOCO1; C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HR5.1 GenPept UniProtKB/Swiss-Prot:Q66HR5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools