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Plpp2 phospholipid phosphatase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246115, updated on 2-Nov-2024

Summary

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Official Symbol
Plpp2provided by RGD
Official Full Name
phospholipid phosphatase 2provided by RGD
Primary source
RGD:628893
See related
EnsemblRapid:ENSRNOG00000000177 AllianceGenome:RGD:628893
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ppap2c
Summary
Predicted to enable ceramide-1-phosphate phosphatase activity; phosphatidate phosphatase activity; and sphingosine-1-phosphate phosphatase activity. Involved in regulation of cell cycle G1/S phase transition. Predicted to be located in caveola; early endosome; and endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human PLPP2 (phospholipid phosphatase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 142.5), Adrenal (RPKM 87.9) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plpp2 in Genome Data Viewer
Location:
7q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10826534..10834628)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (10175918..10184032)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (13062168..13070281)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene sperm microtubule associated protein 2 Neighboring gene MIER family member 2 Neighboring gene uncharacterized LOC120093534 Neighboring gene gonadotropin inducible ovarian transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts. Morris KE, et al. J Biol Chem, 2006 Apr 7. PMID 16467304
  2. Mice mutant for Ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile. Zhang N, et al. Genesis, 2000 Aug. PMID 10992322
  3. Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. Roberts R, et al. J Biol Chem, 1998 Aug 21. PMID 9705349
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ceramide-1-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ceramide-1-phosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidate phosphatase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables sphingosine-1-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables sphingosine-1-phosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ceramide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingosine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
  
located_in caveola ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
phospholipid phosphatase 2
Names
PAP-2c
PAP2-G
PAP2-gamma
PAP2c
lipid phosphate phosphohydrolase 2
phosphatidate phosphohydrolase type 2c
phosphatidic acid phosphatase 2c
phosphatidic acid phosphatase type 2c
NP_640345.1
XP_008763377.1
XP_038934337.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139252.2 → NP_640345.1  phospholipid phosphatase 2

    See identical proteins and their annotated locations for NP_640345.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q8K593
    UniProtKB/TrEMBL
    A0A8I6G688, A6K909
    Related
    ENSRNOP00000000193.1, ENSRNOT00000000193.5
    Conserved Domains (1) summary
    cd03384
    Location:94 → 239
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10826534..10834628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078409.1 → XP_038934337.1  phospholipid phosphatase 2 isoform X2

    Conserved Domains (1) summary
    cl00474
    Location:94 → 172
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

  2. XM_008765155.4 → XP_008763377.1  phospholipid phosphatase 2 isoform X1

    See identical proteins and their annotated locations for XP_008763377.1

    UniProtKB/TrEMBL
    A6K910
    Conserved Domains (1) summary
    cd03384
    Location:38 → 183
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K593.1 GenPept UniProtKB/Swiss-Prot:Q8K593

Gene LinkOut

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