Fgl1 fibrinogen-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fgl1provided by RGD
Official Full Name: fibrinogen-like 1provided by RGD
Primary source: RGD:620169
See related: EnsemblRapid:ENSRNOG00000010714 AllianceGenome:RGD:620169
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Frep1; Lfire1
Summary: Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including hepatocyte proliferation; platelet aggregation; and response to stilbenoid. Predicted to act upstream of or within adipose tissue development; cholesterol metabolic process; and regulation of glucose metabolic process. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human FGL1 (fibrinogen like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 2072.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (57824127..57854413)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (51120652..51150907)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (54153086..54188120)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of FGL1 and p-STAT3 were elevated concurrently with the improvement of liver function.
Title: Bone marrow-derived mesenchymal stem cells attenuate acute liver injury and regulate the expression of fibrinogen-like-protein 1 and signal transducer and activator of transcription 3.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to stilbenoid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibrinogen-like protein 1

Names: fibrinogen-related protein 1; fibronigen-like protein 1; liver fibrinogen-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172010.2 → NP_742007.2 fibrinogen-like protein 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q5M8C6

UniProtKB/TrEMBL

A6JPU2, Q8K583

Related

ENSRNOP00000073912.3, ENSRNOT00000090644.3

Conserved Domains (1) summary

cd00087
Location:80 → 306

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

57824127..57854413

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094195.2 → XP_038950123.1 fibrinogen-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A8L2R9U7, Q8K583

Related

ENSRNOP00000014248.8, ENSRNOT00000014248.8

Conserved Domains (1) summary

cd00087
Location:80 → 262

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...