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Kif27 kinesin family member 27 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246209, updated on 2-Nov-2024

Summary

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Official Symbol
Kif27provided by RGD
Official Full Name
kinesin family member 27provided by RGD
Primary source
RGD:621071
See related
EnsemblRapid:ENSRNOG00000019257 AllianceGenome:RGD:621071
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Krp5
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in cilium assembly and microtubule-based movement. Predicted to act upstream of or within epithelial cilium movement involved in extracellular fluid movement; establishment of localization in cell; and ventricular system development. Predicted to be located in cilium. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Orthologous to human KIF27 (kinesin family member 27). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 128.2), Kidney (RPKM 17.2) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kif27 in Genome Data Viewer
Location:
17p14
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (6304960..6383745)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (6299544..6375106)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (6701287..6776599)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein K Neighboring gene microRNA 7-1 Neighboring gene Q-nucleotide N-glycosylase 1 Neighboring gene kinesin family member 27 like 1 Neighboring gene uncharacterized LOC134482805 Neighboring gene G kinase anchoring protein 1 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Kinesin-related proteins in the mammalian testes: candidate motors for meiosis and morphogenesis. Sperry AO, et al. Mol Biol Cell, 1996 Feb. PMID 8688559, Free PMC Article
  2. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. Oduru S, et al. BMC Genomics, 2003 Jun 3. PMID 12783626, Free PMC Article
  3. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Wilson CW, et al. Nature, 2009 May 7. PMID 19305393, Free PMC Article
  4. Congenital hydrocephalus in genetically engineered mice. Vogel P, et al. Vet Pathol, 2012 Jan. PMID 21746835
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ventricular system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF27
Names
kinesin-related protein KIF27A
kinesin-related protein KRP5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198050.1 → NP_932167.1  kinesin-like protein KIF27

    See identical proteins and their annotated locations for NP_932167.1

    Status: PROVISIONAL

    Source sequence(s)
    BK001053
    UniProtKB/Swiss-Prot
    Q7M6Z5
    UniProtKB/TrEMBL
    A6KAK4
    Related
    ENSRNOP00000026054.5, ENSRNOT00000026054.6
    Conserved Domains (4) summary
    smart00129
    Location:5 → 348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:702 → 1222
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01372
    Location:4 → 342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:789 → 884
    DUF4200; Domain of unknown function (DUF4200)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    6304960..6383745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253556.5 → XP_006253618.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_006253618.1

    UniProtKB/Swiss-Prot
    Q7M6Z5
    UniProtKB/TrEMBL
    A6KAK4
    Conserved Domains (4) summary
    smart00129
    Location:5 → 348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:702 → 1222
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01372
    Location:4 → 342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:789 → 884
    DUF4200; Domain of unknown function (DUF4200)

  2. XM_006253557.5 → XP_006253619.1  kinesin-like protein KIF27 isoform X2

    UniProtKB/TrEMBL
    A0A8L2R9D5, A6KAK4
    Related
    ENSRNOP00000074434.2, ENSRNOT00000080683.3
    Conserved Domains (4) summary
    smart00129
    Location:5 → 348
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:654 → 1174
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01372
    Location:4 → 342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam13863
    Location:741 → 836
    DUF4200; Domain of unknown function (DUF4200)

  3. XM_063276058.1 → XP_063132128.1  kinesin-like protein KIF27 isoform X1

    UniProtKB/Swiss-Prot
    Q7M6Z5

  4. XM_063276059.1 → XP_063132129.1  kinesin-like protein KIF27 isoform X3

  5. XM_063276057.1 → XP_063132127.1  kinesin-like protein KIF27 isoform X1

    UniProtKB/Swiss-Prot
    Q7M6Z5

RNA

  1. XR_360722.5 RNA Sequence

  2. XR_360721.5 RNA Sequence

  3. XR_010058809.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7M6Z5.1 GenPept UniProtKB/Swiss-Prot:Q7M6Z5

Gene LinkOut

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