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Mpst mercaptopyruvate sulfurtransferase [ Mus musculus (house mouse) ]

Gene ID: 246221, updated on 28-Oct-2024

Summary

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Official Symbol
Mpstprovided by MGI
Official Full Name
mercaptopyruvate sulfurtransferaseprovided by MGI
Primary source
MGI:MGI:2179733
See related
Ensembl:ENSMUSG00000071711 AllianceGenome:MGI:2179733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mst; 3MST
Summary
Enables 3-mercaptopyruvate sulfurtransferase activity. Involved in hydrogen sulfide biosynthetic process. Located in neuron projection. Orthologous to human MPST (mercaptopyruvate sulfurtransferase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in colon adult (RPKM 106.7), stomach adult (RPKM 95.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Mpst in Genome Data Viewer
Location:
15 E1; 15 37.47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78290918..78298213)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78406712..78414015)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ciliary microtubule inner protein 4 Neighboring gene STARR-seq mESC enhancer starr_39143 Neighboring gene thiosulfate sulfurtransferase, mitochondrial Neighboring gene predicted gene, 52185 Neighboring gene predicted gene, 36644 Neighboring gene predicted gene, 41355 Neighboring gene potassium channel tetramerisation domain containing 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity. Katsouda A, et al. J Exp Med, 2022 Jul 4. PMID 35616614, Free PMC Article
  2. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts. Panagaki T, et al. Biomolecules, 2020 Apr 23. PMID 32340322, Free PMC Article
  3. The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H(2)S) pathway against experimental osteoarthritis. Nasi S, et al. Arthritis Res Ther, 2020 Mar 17. PMID 32183900, Free PMC Article
  4. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells. Augsburger F, et al. Biomolecules, 2020 Mar 13. PMID 32183148, Free PMC Article
  5. Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain. Kimura Y, et al. Sci Rep, 2015 Oct 6. PMID 26437775, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts.
    Title: Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts.
  2. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells.
    Title: Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells.
  3. The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway against experimental osteoarthritis.
    Title: The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H(2)S) pathway against experimental osteoarthritis.
  4. Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations.
    Title: Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations.
  5. Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.
    Title: Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.
  6. the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE slightly ameliorates the outcome of LPS-induced endotoxemia in vivo.
    Title: Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase.
  7. Up-regulation of 3-MST was located in living neurons and followed neuronal autophagy after traumatic brain injury.
    Title: Upregulation of 3-MST Relates to Neuronal Autophagy After Traumatic Brain Injury in Mice.
  8. H2S3 and H2S are produced in the brain by 3-mercaptopyruvate sulfurtransferase.
    Title: Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain.
  9. 3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide production and function.
    Title: MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery.
  10. behavioral abnormality in MST-KO mice is caused by MST function defects such as an antioxidant insufficiency or a new transducer, H2S (or HS(-)) and/or SOx deficiency.
    Title: Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-mercaptopyruvate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-mercaptopyruvate sulfurtransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-mercaptopyruvate sulfurtransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables thiosulfate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiosulfate sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiosulfate sulfurtransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in hydrogen sulfide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
  
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development IEA
Inferred from Electronic Annotation
more info
  
involved_in liver development ISO
Inferred from Sequence Orthology
more info
  
involved_in spinal cord development IEA
Inferred from Electronic Annotation
more info
  
involved_in transsulfuration IEA
Inferred from Electronic Annotation
more info
  
involved_in transsulfuration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3-mercaptopyruvate sulfurtransferase
NP_001155964.1
NP_001155965.1
NP_001402986.1
NP_001402987.1
NP_001402988.1
NP_001402989.1
NP_001402990.1
NP_619611.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162492.2 → NP_001155964.1  3-mercaptopyruvate sulfurtransferase

    See identical proteins and their annotated locations for NP_001155964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL583893, AL590144
    Consensus CDS
    CCDS27615.1
    UniProtKB/Swiss-Prot
    Q3UW66, Q505N7, Q99J99
    Related
    ENSMUSP00000128075.2, ENSMUST00000169133.8
    Conserved Domains (1) summary
    COG2897
    Location:1 → 279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

  2. NM_001162493.2 → NP_001155965.1  3-mercaptopyruvate sulfurtransferase

    See identical proteins and their annotated locations for NP_001155965.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL583893, AL590144
    Consensus CDS
    CCDS27615.1
    UniProtKB/Swiss-Prot
    Q3UW66, Q505N7, Q99J99
    Related
    ENSMUSP00000130493.2, ENSMUST00000167140.8
    Conserved Domains (1) summary
    COG2897
    Location:1 → 279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

  3. NM_001416057.1 → NP_001402986.1  3-mercaptopyruvate sulfurtransferase

    Status: VALIDATED

    Source sequence(s)
    AL583893, AL590144
    UniProtKB/Swiss-Prot
    Q3UW66, Q505N7, Q99J99

  4. NM_001416058.1 → NP_001402987.1  3-mercaptopyruvate sulfurtransferase

    Status: VALIDATED

    Source sequence(s)
    AL583893, AL590144
    UniProtKB/Swiss-Prot
    Q3UW66, Q505N7, Q99J99

  5. NM_001416059.1 → NP_001402988.1  3-mercaptopyruvate sulfurtransferase

    Status: VALIDATED

    Source sequence(s)
    AL583893, AL590144
    UniProtKB/Swiss-Prot
    Q3UW66, Q505N7, Q99J99

  6. NM_001416060.1 → NP_001402989.1  3-mercaptopyruvate sulfurtransferase

    Status: VALIDATED

    Source sequence(s)
    AL583893, AL590144
    UniProtKB/Swiss-Prot
    Q3UW66, Q505N7, Q99J99

  7. NM_001416061.1 → NP_001402990.1  3-mercaptopyruvate sulfurtransferase

    Status: VALIDATED

    Source sequence(s)
    AL583893, AL590144
    UniProtKB/Swiss-Prot
    Q3UW66, Q505N7, Q99J99

  8. NM_138670.4 → NP_619611.3  3-mercaptopyruvate sulfurtransferase

    See identical proteins and their annotated locations for NP_619611.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL583893, AL590144
    Consensus CDS
    CCDS27615.1
    UniProtKB/Swiss-Prot
    Q3UW66, Q505N7, Q99J99
    Related
    ENSMUSP00000043061.7, ENSMUST00000043865.8
    Conserved Domains (1) summary
    COG2897
    Location:1 → 279
    SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78290918..78298213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99J99.4 GenPept UniProtKB/Swiss-Prot:Q99J99

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