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Fmo2 flavin containing dimethylaniline monoxygenase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246245, updated on 6-Jun-2024

Summary

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Official Symbol
Fmo2provided by RGD
Official Full Name
flavin containing dimethylaniline monoxygenase 2provided by RGD
Primary source
RGD:628600
See related
Ensembl:ENSRNOG00000003510 AllianceGenome:RGD:628600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N,N-dimethylaniline monooxygenase activity. Predicted to be involved in several processes, including NADPH oxidation; toxin metabolic process; and xenobiotic metabolic process. Predicted to act upstream of or within oxygen metabolic process. Predicted to be located in membrane. Orthologous to human FMO2 (flavin containing dimethylaniline monoxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 422.4), Kidney (RPKM 173.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fmo2 in Genome Data Viewer
Location:
13q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (77755131..77777597, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (75221149..75244377, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (80752526..80775264, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555487 Neighboring gene flavin containing dimethylaniline monoxygenase 4 Neighboring gene flavin containing dimethylaniline monoxygenase 1 Neighboring gene heat shock protein 90 alpha family class A member 1, pseudogene 13 Neighboring gene uncharacterized LOC134481523

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of the FMO2 gene in Rattus norvegicus: a good model to study metabolic and toxicological consequences of the FMO2 polymorphism. Hugonnard M, et al. Pharmacogenetics, 2004 Oct. PMID 15454729
  2. Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse. Karoly ED, et al. J Biochem Mol Toxicol, 2001. PMID 11835629
  3. Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. Krueger SK, et al. Drug Metab Dispos, 2002 Jan. PMID 11744609
  4. The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein. Dolphin CT, et al. J Biol Chem, 1998 Nov 13. PMID 9804831
  5. The FMO2 gene of laboratory rats, as in most humans, encodes a truncated protein. Lattard V, et al. Biochem Biophys Res Commun, 2002 Mar 29. PMID 11906197

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FMO2 genetic polymorphism was associated with major differences in the S-oxidative metabolism.
    Title: Identification and characterization of the FMO2 gene in Rattus norvegicus: a good model to study metabolic and toxicological consequences of the FMO2 polymorphism.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N,N-dimethylaniline monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables N,N-dimethylaniline monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables hypotaurine dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in NADP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NADPH oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in NADPH oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in NADPH oxidation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in energy homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within energy homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fatty acid oxidation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in organic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oxygen metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oxygen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in toxin metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in toxin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dimethylaniline monooxygenase [N-oxide-forming] 2
Names
FMO 2
dimethylaniline oxidase 2
flavin containing monooxygenase 2
pulmonary flavin-containing monooxygenase 2
NP_653338.2
XP_063128091.1
XP_063128092.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144737.2 → NP_653338.2  dimethylaniline monooxygenase [N-oxide-forming] 2

    See identical proteins and their annotated locations for NP_653338.2

    Status: VALIDATED

    Source sequence(s)
    BC070904, CK365136
    UniProtKB/Swiss-Prot
    Q6IRI9
    UniProtKB/TrEMBL
    A6IDA6, G3V6F6
    Related
    ENSRNOP00000004762.3, ENSRNOT00000004762.6
    Conserved Domains (3) summary
    pfam00743
    Location:3 → 532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:7 → 58
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl21454
    Location:78 → 340
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    77755131..77777597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272021.1 → XP_063128091.1  dimethylaniline monooxygenase [N-oxide-forming] 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6IRI9
    UniProtKB/TrEMBL
    A6IDA6, G3V6F6

  2. XM_063272022.1 → XP_063128092.1  dimethylaniline monooxygenase [N-oxide-forming] 2 isoform X2

RNA

  1. XR_005492201.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IRI9.3 GenPept UniProtKB/Swiss-Prot:Q6IRI9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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