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Fmo4 flavin containing dimethylaniline monoxygenase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246247, updated on 2-Nov-2024

Summary

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Official Symbol
Fmo4provided by RGD
Official Full Name
flavin containing dimethylaniline monoxygenase 4provided by RGD
Primary source
RGD:628601
See related
EnsemblRapid:ENSRNOG00000003400 AllianceGenome:RGD:628601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N,N-dimethylaniline monooxygenase activity. Predicted to act upstream of or within energy homeostasis; negative regulation of fatty acid oxidation; and xenobiotic catabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human FMO4 (flavin containing dimethylaniline monoxygenase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 503.9), Liver (RPKM 55.5) and 1 other tissue See more
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Genomic context

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See Fmo4 in Genome Data Viewer
Location:
13q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (77687909..77706100, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (75154683..75172874, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (80685385..80703575, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene myocilin Neighboring gene proline-rich coiled-coil 2C Neighboring gene uncharacterized LOC134481577 Neighboring gene uncharacterized LOC102555487 Neighboring gene flavin containing dimethylaniline monoxygenase 1 Neighboring gene flavin containing dimethylaniline monoxygenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning, sequencing and tissue distribution of rat flavin-containing monooxygenase 4: two different forms are produced by tissue-specific alternative splicing. Lattard V, et al. Mol Pharmacol, 2003 Jan. PMID 12488558
  2. Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q. McCombie RR, et al. Genomics, 1996 Jun 15. PMID 8786146
  3. Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes. Novick RM, et al. J Pharmacol Exp Ther, 2009 Jun. PMID 19307449, Free PMC Article
  4. Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine. Hernandez D, et al. Pharmacogenet Genomics, 2009 Apr. PMID 19262426
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes.
    Title: Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes.
  2. By Western blotting using the two different forms of FMO4 antibodies, a long FMO4 protein was detected in the rat kidney, whereas in the rat brain, only the short form of FMO4 was observed.
    Title: Cloning, sequencing and tissue distribution of rat flavin-containing monooxygenase 4: two different forms are produced by tissue-specific alternative splicing.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93155

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N,N-dimethylaniline monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables hypotaurine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within energy homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dimethylaniline monooxygenase [N-oxide-forming] 4
Names
FMO 4
dimethylaniline oxidase 4
flavin containing monooxygenase 4
hepatic flavin-containing monooxygenase 4
NP_653147.2
NP_653148.2
XP_038946261.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144561.3 → NP_653147.2  dimethylaniline monooxygenase [N-oxide-forming] 4 long isoform

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q66HR6, Q8K4B7
    UniProtKB/TrEMBL
    A0A8I6AMY0, A6IDA2
    Related
    ENSRNOP00000004599.2, ENSRNOT00000004599.7
    Conserved Domains (1) summary
    pfam00743
    Location:2 → 530
    FMO-like; Flavin-binding monooxygenase-like

  2. NM_144562.2 → NP_653148.2  dimethylaniline monooxygenase [N-oxide-forming] 4 short isoform

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6IDA1, G3V6F2, Q8K4B6
    Related
    ENSRNOP00000004577.4, ENSRNOT00000004577.8
    Conserved Domains (1) summary
    pfam00743
    Location:2 → 467
    FMO-like; Flavin-binding monooxygenase-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    77687909..77706100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090333.2 → XP_038946261.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1

    UniProtKB/TrEMBL
    Q8K4B6
    Conserved Domains (1) summary
    pfam00743
    Location:1 → 387
    FMO-like; Flavin-binding monooxygenase-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4B7.3 GenPept UniProtKB/Swiss-Prot:Q8K4B7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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