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Oas1b 2-5 oligoadenylate synthetase 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 246268, updated on 2-Nov-2024

Summary

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Official Symbol
Oas1bprovided by RGD
Official Full Name
2-5 oligoadenylate synthetase 1Bprovided by RGD
Primary source
RGD:708393
See related
EnsemblRapid:ENSRNOG00000033220 AllianceGenome:RGD:708393
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable double-stranded RNA binding activity. Predicted to be involved in innate immune response; interleukin-27-mediated signaling pathway; and negative regulation of viral genome replication. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol; membrane; and nucleoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 51.7), Lung (RPKM 40.3) and 9 other tissues See more
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Genomic context

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See Oas1b in Genome Data Viewer
Location:
12q16
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41385184..41395891, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35724561..35735271, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41255762..41266430, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1H Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1F Neighboring gene 2'-5' oligoadenylate synthetase 1E Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human T-cell leukemia virus type 1 Tax protein stimulates the interferon-responsive enhancer element via NF-kappaB activity. Shimizu T, et al. FEBS Lett, 2003 Mar 27. PMID 12650929
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC108585

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables 2'-5'-oligoadenylate synthetase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-27-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inactive 2'-5'-oligoadenylate synthase 1B
Names
(2-5')oligo(A) synthase 1B
2'5' oligoadenylate synthetase-2
2-5A synthase 1B
25 oligoadenylate synthetase-2
NP_653353.2
XP_038944996.1
XP_038944997.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144752.2 → NP_653353.2  inactive 2'-5'-oligoadenylate synthase 1B

    See identical proteins and their annotated locations for NP_653353.2

    Status: PROVISIONAL

    Source sequence(s)
    BC091121
    UniProtKB/Swiss-Prot
    O70522, Q5BKD0
    UniProtKB/TrEMBL
    A0A8L2PZR9
    Related
    ENSRNOP00000042591.5, ENSRNOT00000048782.6
    Conserved Domains (2) summary
    cd05400
    Location:27 → 176
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:164 → 347
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    41385184..41395891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089068.2 → XP_038944996.1  inactive 2'-5'-oligoadenylate synthase 1B isoform X1

    Conserved Domains (1) summary
    pfam10421
    Location:31 → 216
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

  2. XM_039089069.2 → XP_038944997.1  inactive 2'-5'-oligoadenylate synthase 1B isoform X2

    Conserved Domains (1) summary
    pfam10421
    Location:4 → 189
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RNA

  1. XR_005491597.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BKD0.1 GenPept UniProtKB/Swiss-Prot:Q5BKD0

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