U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arfgap1 ADP-ribosylation factor GTPase activating protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246310, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Arfgap1provided by RGD
Official Full Name
ADP-ribosylation factor GTPase activating protein 1provided by RGD
Primary source
RGD:708452
See related
EnsemblRapid:ENSRNOG00000043150 AllianceGenome:RGD:708452
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arf1gap; Arf GAP1
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of endocytosis. Located in Golgi membrane. Orthologous to human ARFGAP1 (ADP ribosylation factor GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 153.2), Muscle (RPKM 148.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Arfgap1 in Genome Data Viewer
Location:
3q43
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188462125..188477515)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168084560..168099948)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176475847..176490642)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene baculoviral IAP repeat-containing 7 Neighboring gene Sodium/potassium transporting ATPase interacting 4 Neighboring gene collagen type XX alpha 1 chain Neighboring gene cholinergic receptor nicotinic alpha 4 subunit Neighboring gene potassium voltage-gated channel subfamily Q member 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ArfGAP1 interacts with coat proteins through tryptophan-based motifs. Rawet M, et al. Biochem Biophys Res Commun, 2010 Apr 9. PMID 20211604
  2. Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature. Mesmin B, et al. Biochemistry, 2007 Feb 20. PMID 17253781
  3. Golgi localization determinants in ArfGAP1 and in new tissue-specific ArfGAP1 isoforms. Parnis A, et al. J Biol Chem, 2006 Feb 17. PMID 16316994
  4. Sorting of Golgi resident proteins into different subpopulations of COPI vesicles: a role for ArfGAP1. Lanoix J, et al. J Cell Biol, 2001 Dec 24. PMID 11748249, Free PMC Article
  5. ADP-ribosylation factor-directed GTPase-activating protein. Purification and partial characterization. Makler V, et al. J Biol Chem, 1995 Mar 10. PMID 7890632

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these findings point to mechanistic differences between ArfGAP1 and the other ArfGAPs known to function in the COPI system.
    Title: ArfGAP1 interacts with coat proteins through tryptophan-based motifs.
  2. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking
    Title: Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking.
  3. ALPS1 is the primary determinant of the interaction of ArfGAP1 with lipid membranes and that ALPS2 reinforces this interaction 40-fold; ArfGAP1 responds to a wide range of membrane curvature and adapts to lipid membranes of various acyl chain compositions
    Title: Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature.
  4. Data show that casein kinase I is required for protein traffic through the early secretory pathway and can modulate the amount of ADP-ribosylation factor-GTPase activating protein (ARF-GAP1) that can bind to membranes.
    Title: Casein kinase I regulates membrane binding by ARF GAP1.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activator activity TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ARF protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ADP-ribosylation factor GTPase-activating protein 1
Names
ADP-ribosylation factor 1 GTPase-activating protein
ARF GAP 1
ARF1 GAP
ARF1-directed GTPase-activating protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145090.4 → NP_659558.1  ADP-ribosylation factor GTPase-activating protein 1

    See identical proteins and their annotated locations for NP_659558.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q62848
    UniProtKB/TrEMBL
    A0A0H2UHZ3, A6KM64
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    188462125..188477515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235732.4 → XP_006235794.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006235794.1

    UniProtKB/TrEMBL
    A0A0H2UHZ3, Q3S4A4
    Related
    ENSRNOP00000013900.5, ENSRNOT00000013900.8
    Conserved Domains (2) summary
    pfam01412
    Location:7 → 114
    ArfGap; Putative GTPase activating protein for Arf
    pfam13257
    Location:325 → 376
    DUF4048; Domain of unknown function (DUF4048)

  2. XM_063283084.1 → XP_063139154.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X3

  3. XM_063283085.1 → XP_063139155.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X4

    UniProtKB/TrEMBL
    Q3S4A5

  4. XM_063283087.1 → XP_063139157.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X5

    Related
    ENSRNOP00000073451.2, ENSRNOT00000082267.3

  5. XM_063283089.1 → XP_063139159.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X6

  6. XM_006235731.4 → XP_006235793.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006235793.1

    UniProtKB/TrEMBL
    A0A0H2UHZ3, Q3S4A4
    Conserved Domains (2) summary
    pfam01412
    Location:7 → 114
    ArfGap; Putative GTPase activating protein for Arf
    pfam13257
    Location:325 → 376
    DUF4048; Domain of unknown function (DUF4048)

  7. XM_063283086.1 → XP_063139156.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X4

    UniProtKB/TrEMBL
    Q3S4A5

  8. XM_063283088.1 → XP_063139158.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X5

  9. XM_063283090.1 → XP_063139160.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X6

  10. XM_039104259.2 → XP_038960187.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q62848
    UniProtKB/TrEMBL
    A0A0H2UHZ3, A6KM64
    Related
    ENSRNOP00000051916.5, ENSRNOT00000055038.5
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  11. XM_063283091.1 → XP_063139161.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X7

RNA

  1. XR_010064557.1 RNA Sequence

  2. XR_010064559.1 RNA Sequence

  3. XR_010064560.1 RNA Sequence

  4. XR_010064558.1 RNA Sequence

  5. XR_010064561.1 RNA Sequence

  6. XR_010064562.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62848.1 GenPept UniProtKB/Swiss-Prot:Q62848

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous