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Prokr2 prokineticin receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 246313, updated on 2-Nov-2024

Summary

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Official Symbol
Prokr2provided by MGI
Official Full Name
prokineticin receptor 2provided by MGI
Primary source
MGI:MGI:2181363
See related
Ensembl:ENSMUSG00000050558 AllianceGenome:MGI:2181363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PKR2; Gpr73l1; Gpcr73l1; EG-VEGRF2; B830005M06Rik
Summary
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within circadian rhythm. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; hemolymphoid system gland; nose; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 3 with or without anosmia. Orthologous to human PROKR2 (prokineticin receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 1.4), CNS E18 (RPKM 1.3) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Prokr2 in Genome Data Viewer
Location:
2 F2; 2 64.15 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132211625..132227413, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132369705..132385502, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:132079079-132079188 Neighboring gene STARR-positive B cell enhancer ABC_E331 Neighboring gene expressed sequence AV099323 Neighboring gene predicted gene, 46766 Neighboring gene STARR-seq mESC enhancer starr_05740 Neighboring gene CDP-diacylglycerol synthase 2 Neighboring gene STARR-positive B cell enhancer ABC_E5987 Neighboring gene STARR-seq mESC enhancer starr_05741 Neighboring gene STARR-seq mESC enhancer starr_05742 Neighboring gene RIKEN cDNA 4921508D12 gene Neighboring gene VISTA enhancer mm1391 Neighboring gene predicted gene 14095

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phenotypic and genotypic landscape of PROKR2 in neuroendocrine disorders. Martinez-Mayer J, et al. Front Endocrinol (Lausanne), 2023. PMID 36843573, Free PMC Article
  2. Transgenic myocardial overexpression of prokineticin receptor-2 (GPR73b) induces hypertrophy and capillary vessel leakage. Urayama K, et al. Cardiovasc Res, 2009 Jan 1. PMID 18806277
  3. Prokr2-deficient mice display vascular dysmorphology of the fetal testes: potential implications for Kallmann syndrome aetiology. Svingen T, et al. Sex Dev, 2011. PMID 22223120
  4. Pressure Overload-Mediated Sustained PKR2 (Prokineticin-2 Receptor) Signaling in Cardiomyocytes Contributes to Cardiac Hypertrophy and Endotheliopathies. Demir F, et al. Hypertension, 2021 May 5. PMID 33677981
  5. Efferent projections of prokineticin 2 expressing neurons in the mouse suprachiasmatic nucleus. Zhang C, et al. PLoS One, 2009 Sep 28. PMID 19784373, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phenotypic and genotypic landscape of PROKR2 in neuroendocrine disorders.
    Title: Phenotypic and genotypic landscape of PROKR2 in neuroendocrine disorders.
  2. Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to beta-arrestin 2.
    Title: Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
  3. Pressure Overload-Mediated Sustained PKR2 (Prokineticin-2 Receptor) Signaling in Cardiomyocytes Contributes to Cardiac Hypertrophy and Endotheliopathies.
    Title: Pressure Overload-Mediated Sustained PKR2 (Prokineticin-2 Receptor) Signaling in Cardiomyocytes Contributes to Cardiac Hypertrophy and Endotheliopathies.
  4. Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network.
    Title: Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network.
  5. The regulatory G protein signaling complex, Gbeta5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion.
    Title: The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion.
  6. The PROK2/PROKR2 signaling pathway is required for the migration of most olfactory bulb interneurons.
    Title: The PROK2/PROKR2 signaling pathway is required for the migration of most olfactory bulb interneurons.
  7. infiltrating neutrophils and 4T1 cells abundantly expressed prokineticin-2 (Prok2) and its receptor, Prokr1, respectively. Finally, the administration of 5-FU after the resection of the primary tumor failed to augment lung metastasis in the mice receiving Prokr1-deleted 4T1 cells.
    Title: Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung.
  8. The sexually dimorphic pattern of Prokr2 expression indicates differential roles in reproductive function and, potentially, in other physiological systems.
    Title: Sexually dimorphic distribution of Prokr2 neurons revealed by the Prokr2-Cre mouse model.
  9. This study presents the first experimental evidence indicating a molecular interaction between anosmin 1 and PKR2. A truncated anosmin 1 protein comprising the first three domains of the protein interacts with the second extracellular loop of PKR2, involved in PK2 binding.
    Title: Anosmin 1 Interacts with the Prokineticin Receptor 2 In Vitro Indicating a Molecular Link Between Both Proteins in the Pathogenesis of Kallmann Syndrome.
  10. Data show that the prokineticins and their receptors PROK2, PKR1 and PKR2 contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease.
    Title: Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within circadian rhythm IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
prokineticin receptor 2
Names
G protein-coupled receptor 73-like 1
PK-R2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144944.3 → NP_659193.3  prokineticin receptor 2

    See identical proteins and their annotated locations for NP_659193.3

    Status: VALIDATED

    Source sequence(s)
    AL807793, BB844646, BC043116
    Consensus CDS
    CCDS16773.1
    UniProtKB/Swiss-Prot
    A2AMQ8, Q80XQ0, Q8BIR4, Q8K458
    UniProtKB/TrEMBL
    Q6GTF8
    Related
    ENSMUSP00000056659.8, ENSMUST00000049997.14
    Conserved Domains (1) summary
    cd15204
    Location:51 → 341
    7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    132211625..132227413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239558.4 → XP_011237860.1  prokineticin receptor 2 isoform X3

    UniProtKB/TrEMBL
    E0CY28
    Related
    ENSMUSP00000124526.2, ENSMUST00000142766.2
    Conserved Domains (2) summary
    cd14964
    Location:5 → 26
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:1 → 180
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_011239555.3 → XP_011237857.1  prokineticin receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011237857.1

    UniProtKB/Swiss-Prot
    A2AMQ8, Q80XQ0, Q8BIR4, Q8K458
    UniProtKB/TrEMBL
    Q6GTF8
    Related
    ENSMUSP00000105784.2, ENSMUST00000110156.2
    Conserved Domains (1) summary
    cd15204
    Location:51 → 341
    7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_011239557.3 → XP_011237859.1  prokineticin receptor 2 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:66 → 87
    7tm_GPCRs; TM helix 4 [structural motif]
    cl28897
    Location:50 → 241
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K458.1 GenPept UniProtKB/Swiss-Prot:Q8K458

Gene LinkOut

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