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Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 24667, updated on 10-Jul-2024

Summary

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Official Symbol
Ppm1bprovided by RGD
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1Bprovided by RGD
Primary source
RGD:3374
See related
EnsemblRapid:ENSRNOG00000030667 AllianceGenome:RGD:3374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pp2c2; PP2C-beta
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in several processes, including cellular protein modification process; negative regulation of interferon-beta production; and negative regulation of intracellular signal transduction. Predicted to be located in membrane and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 227.9), Thymus (RPKM 202.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppm1b in Genome Data Viewer
Location:
6q12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (15399559..15460301, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (9646695..9707471, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (8219385..8280127)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479091 Neighboring gene prolyl endopeptidase-like Neighboring gene solute carrier family 3 member 1 Neighboring gene cilia- and flagella-associated protein 251-like Neighboring gene uncharacterized LOC100910809

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Monoclonal anti-FLAG antibodies react with a new isoform of rat Mg2+ dependent protein phosphatase beta. Schäfer K, et al. Biochem Biophys Res Commun, 1995 Feb 15. PMID 7532404
  2. Molecular cloning and primary structure of a protein phosphatase 2C isoform. Wenk J, et al. FEBS Lett, 1992 Feb 3. PMID 1312947
  3. PPM1B negatively regulates antiviral response via dephosphorylating TBK1. Zhao Y, et al. Cell Signal, 2012 Nov. PMID 22750291, Free PMC Article
  4. Differentiation-dependent enhanced expression of protein phosphatase 2Cbeta in germ cells of mouse seminiferous tubules. Kato S, et al. FEBS Lett, 1996 Nov 4. PMID 8915006
  5. PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Sun W, et al. Cell Signal, 2009 Jan. PMID 18930133, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interferon-beta production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-threonine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein phosphatase 1B
NP_001257548.1
NP_001257549.1
NP_149087.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270619.2 → NP_001257548.1  protein phosphatase 1B isoform 2

    See identical proteins and their annotated locations for NP_001257548.1

    Status: VALIDATED

    Source sequence(s)
    AJ271837, EV777419, JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A0G2K7Q5, A6H9I0, Q6P6W5, Q99ND8
    Related
    ENSRNOP00000099191.1, ENSRNOT00000154745.1
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 365
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  2. NM_001270620.2 → NP_001257549.1  protein phosphatase 1B isoform 3

    See identical proteins and their annotated locations for NP_001257549.1

    Status: VALIDATED

    Source sequence(s)
    AJ271837, EV777419, JAXUCZ010000006
    UniProtKB/TrEMBL
    A6H9H8, D3ZLY2, Q642F2
    Related
    ENSRNOP00000102147.1, ENSRNOT00000167508.1
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 365
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

  3. NM_033096.3 → NP_149087.1  protein phosphatase 1B isoform 1

    See identical proteins and their annotated locations for NP_149087.1

    Status: VALIDATED

    Source sequence(s)
    AJ271837, EV777419, JAXUCZ010000006
    UniProtKB/Swiss-Prot
    P35815, Q546R0, Q64046
    UniProtKB/TrEMBL
    A6H9H5, A6H9H9
    Related
    ENSRNOP00000109449.1, ENSRNOT00000151256.1
    Conserved Domains (2) summary
    cd00143
    Location:23 → 295
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:289 → 365
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    15399559..15460301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35815.1 GenPept UniProtKB/Swiss-Prot:P35815

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