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Slc25a28 solute carrier family 25, member 28 [ Mus musculus (house mouse) ]

Gene ID: 246696, updated on 2-Nov-2024

Summary

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Official Symbol
Slc25a28provided by MGI
Official Full Name
solute carrier family 25, member 28provided by MGI
Primary source
MGI:MGI:2180509
See related
Ensembl:ENSMUSG00000040414 AllianceGenome:MGI:2180509
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mfrn2; Mrs3/4
Summary
Enables ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Located in mitochondrion. Is expressed in several structures, including genitourinary system; gut; immune system; liver; and lung. Orthologous to human SLC25A28 (solute carrier family 25 member 28). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 37.3), adrenal adult (RPKM 28.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc25a28 in Genome Data Viewer
Location:
19 C3; 19 36.67 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43652240..43663320, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43663801..43675006, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene NK2 homeobox 3 Neighboring gene predicted gene, 34922 Neighboring gene STARR-seq mESC enhancer starr_46201 Neighboring gene predicted gene 4311 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:43749453-43749636 Neighboring gene cDNA sequence BC037704 Neighboring gene STARR-positive B cell enhancer ABC_E7661 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene cytochrome c oxidase assembly protein 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Microglial SLC25A28 Deficiency Ameliorates the Brain Injury After Intracerebral Hemorrhage in Mice by Restricting Aerobic Glycolysis. Han R, et al. Inflammation, 2024 Apr. PMID 38085466
  2. Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2. Klag KA, et al. Nutrients, 2024 Jun 8. PMID 38931165, Free PMC Article
  3. SLC25A28 Overexpression Promotes Adipogenesis by Reducing ATGL. Guan H, et al. J Diabetes Res, 2024. PMID 38736904, Free PMC Article
  4. Characterization of a novel human putative mitochondrial transporter homologous to the yeast mitochondrial RNA splicing proteins 3 and 4. Li FY, et al. FEBS Lett, 2001 Apr 6. PMID 11297739
  5. Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis. Wang D, et al. Exp Cell Res, 2021 May 1. PMID 33711329

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2.
    Title: Low-Iron Diet-Induced Fatty Liver Development Is Microbiota Dependent and Exacerbated by Loss of the Mitochondrial Iron Importer Mitoferrin2.
  2. SLC25A28 Overexpression Promotes Adipogenesis by Reducing ATGL.
    Title: SLC25A28 Overexpression Promotes Adipogenesis by Reducing ATGL.
  3. Microglial SLC25A28 Deficiency Ameliorates the Brain Injury After Intracerebral Hemorrhage in Mice by Restricting Aerobic Glycolysis.
    Title: Microglial SLC25A28 Deficiency Ameliorates the Brain Injury After Intracerebral Hemorrhage in Mice by Restricting Aerobic Glycolysis.
  4. Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis.
    Title: Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis.
  5. The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice.
    Title: The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice.
  6. The cis-regulatory modules (CRMs) that control expression of the Mfrn genes, were mapped.
    Title: Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis.
  7. Mitoferrin 1 and mitoferrin 2 contribute to mitochondrial iron delivery in a variety of cells.
    Title: Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Clone Names

  • 2210403D18Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ferrous iron transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables ferrous iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in iron import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitoferrin-2
Names
mitochondrial RNA-splicing protein 3/4 homolog
mitochondrial iron transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356944.1 → NP_001343873.1  mitoferrin-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, resulting in a novel 5' UTR and the use of a downstream start codon, compared to variant 1 The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC138790, AF377993, BE849400
    Conserved Domains (1) summary
    pfam00153
    Location:1 → 66
    Mito_carr; Mitochondrial carrier protein

  2. NM_145156.1 → NP_660138.1  mitoferrin-2 isoform 1

    See identical proteins and their annotated locations for NP_660138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC138790, AF377994, BE849400
    Consensus CDS
    CCDS29834.1
    UniProtKB/Swiss-Prot
    Q8K4J8, Q8K4J9, Q8R0Z5, Q8R578
    Related
    ENSMUSP00000036913.8, ENSMUST00000046038.9
    Conserved Domains (1) summary
    pfam00153
    Location:71 → 161
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    43652240..43663320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318202.3 → XP_017173691.1  mitoferrin-2 isoform X1

    Conserved Domains (1) summary
    pfam00153
    Location:76 → 160
    Mito_carr; Mitochondrial carrier protein

  2. XM_006527097.3 → XP_006527160.1  mitoferrin-2 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:4 → 82
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0Z5.1 GenPept UniProtKB/Swiss-Prot:Q8R0Z5

Gene LinkOut

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