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Rhobtb2 Rho-related BTB domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 246710, updated on 28-Oct-2024

Summary

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Official Symbol
Rhobtb2provided by MGI
Official Full Name
Rho-related BTB domain containing 2provided by MGI
Primary source
MGI:MGI:2180557
See related
Ensembl:ENSMUSG00000022075 AllianceGenome:MGI:2180557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dbc2; mKIAA0717; E130206H14Rik
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; integumental system; and nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 64. Orthologous to human RHOBTB2 (Rho related BTB domain containing 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in cortex adult (RPKM 14.0), frontal lobe adult (RPKM 11.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rhobtb2 in Genome Data Viewer
Location:
14 D2; 14 36.1 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70022439..70062296, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (69784990..69824847, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930480K23 gene Neighboring gene STARR-seq mESC enhancer starr_37064 Neighboring gene tumor necrosis factor receptor superfamily, member 10b Neighboring gene PR domain containing 4 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10832 Neighboring gene STARR-positive B cell enhancer ABC_E7329 Neighboring gene STARR-positive B cell enhancer ABC_E5452 Neighboring gene STARR-seq mESC enhancer starr_37068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70261408-70261517 Neighboring gene STARR-positive B cell enhancer ABC_E9049 Neighboring gene phosphatidylethanolamine binding protein 4 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene ribosomal protein S11 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Hamaguchi M, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370419, Free PMC Article
  2. High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor. St-Pierre B, et al. Gene Expr Patterns, 2004 Dec. PMID 15567721
  3. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. Ramos S, et al. Gene, 2002 Oct 2. PMID 12426103
  4. Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. Lutz J, et al. Histochem Cell Biol, 2014 Nov. PMID 24923387
  5. MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein. Schenková K, et al. J Mol Biol, 2012 Oct 5. PMID 22709582

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. There is no connection between elevated expression of mDbc2/Rhobtb2 and a specific stage of mammary gland development, but this gene plays a critical role in the development of the nervous system.
    Title: High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28699

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho-related BTB domain-containing protein 2
Names
deleted in breast cancer 2 gene protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153514.5 → NP_705734.4  rho-related BTB domain-containing protein 2

    See identical proteins and their annotated locations for NP_705734.4

    Status: VALIDATED

    Source sequence(s)
    AC162936
    Consensus CDS
    CCDS27244.1
    UniProtKB/Swiss-Prot
    Q8BYU3, Q8K1A8, Q91V93
    UniProtKB/TrEMBL
    Q8BV20
    Related
    ENSMUSP00000022665.3, ENSMUST00000022665.4
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18359
    Location:480 → 603
    BTB2_POZ_RHOBTB2; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
    cd18531
    Location:608 → 704
    BACK_RHOBTB2; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
    cl38908
    Location:250 → 475
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70022439..70062296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158600.1 → XP_036014493.1  rho-related BTB domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    Q8BV20
    Conserved Domains (4) summary
    cd01873
    Location:35 → 229
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18359
    Location:502 → 625
    BTB2_POZ_RHOBTB2; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
    cd18531
    Location:630 → 726
    BACK_RHOBTB2; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
    cl38908
    Location:272 → 497
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  2. XM_030247818.2 → XP_030103678.1  rho-related BTB domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8BYU3, Q8K1A8, Q91V93
    UniProtKB/TrEMBL
    Q8BV20
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18359
    Location:480 → 603
    BTB2_POZ_RHOBTB2; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
    cd18531
    Location:608 → 704
    BACK_RHOBTB2; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
    cl38908
    Location:250 → 475
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91V93.2 GenPept UniProtKB/Swiss-Prot:Q91V93

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