Oas3 2'-5' oligoadenylate synthetase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oas3provided by MGI
Official Full Name: 2'-5' oligoadenylate synthetase 3provided by MGI
Primary source: MGI:MGI:2180850
See related: Ensembl:ENSMUSG00000032661 AllianceGenome:MGI:2180850
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Oasl10
Summary: Enables 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Predicted to be involved in several processes, including defense response to other organism; regulation of cytokine production; and regulation of innate immune response. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol; membrane; and nucleoplasm. Orthologous to human OAS3 (2'-5'-oligoadenylate synthetase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in small intestine adult (RPKM 15.4), duodenum adult (RPKM 12.6) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 60.64 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (120891163..120915755, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (120753098..120777684, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC123253P1 (e-PCR)
- UniSTS:270446

RH127293 (e-PCR)
- UniSTS:207867

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2'-5'-oligoadenylate synthetase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2'-5'-oligoadenylate synthetase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2'-5'-oligoadenylate synthetase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MDA-5 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in MDA-5 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in RIG-I signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-27-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of IP-10 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of IP-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine (C-C motif) ligand 5 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine (C-C motif) ligand 5 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine (C-X-C motif) ligand 9 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine (C-X-C motif) ligand 9 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotactic protein-1 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of ribonuclease activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of ribonuclease activity	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 2'-5'-oligoadenylate synthase 3

Names: (2-5')oligo(A) synthase 3; 2',5'-oligoadenylate synthetase-like 10; 2-5A synthase 3

NP_660261.1

EC 2.7.7.84

XP_030110371.1

EC 2.7.7.84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145226.2 → NP_660261.1 2'-5'-oligoadenylate synthase 3

See identical proteins and their annotated locations for NP_660261.1

Status: VALIDATED

Source sequence(s)

AC115937

Consensus CDS

CCDS39242.1

UniProtKB/Swiss-Prot

B9EIU4, Q8K4D2, Q8VI93

Related

ENSMUSP00000035588.9, ENSMUST00000044833.9

Conserved Domains (2) summary

cd05400
Location:820 → 999

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:954 → 1135

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

120891163..120915755 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254511.2 → XP_030110371.1 2'-5'-oligoadenylate synthase 3 isoform X1

Conserved Domains (2) summary

cd05400
Location:820 → 999

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:955 → 1137

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus