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Cd300lf CD300 molecule like family member F [ Mus musculus (house mouse) ]

Gene ID: 246746, updated on 28-Oct-2024

Summary

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Official Symbol
Cd300lfprovided by MGI
Official Full Name
CD300 molecule like family member Fprovided by MGI
Primary source
MGI:MGI:2442359
See related
Ensembl:ENSMUSG00000047798 AllianceGenome:MGI:2442359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CLM1; CLIM1; CLM-1; Digr2; IREM1; LMIR3; Pigr3; IgSF13; F730004D16Rik
Summary
Enables several functions, including interleukin-4 receptor binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in several processes, including interleukin-13-mediated signaling pathway; positive regulation of interleukin-4-mediated signaling pathway; and regulation of apoptotic cell clearance. Acts upstream of or within osteoclast differentiation. Predicted to be active in plasma membrane. Is expressed in early conceptus; embryo; and retina. Orthologous to human CD300LF (CD300 molecule like family member f). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in spleen adult (RPKM 7.7), liver E18 (RPKM 5.1) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Cd300lf in Genome Data Viewer
Location:
11 E2; 11 80.59 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115007040..115024834, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115116214..115135372, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31142 Neighboring gene CD300 molecule like family member D3 Neighboring gene CD300E molecule Neighboring gene STARR-seq mESC enhancer starr_31143 Neighboring gene STARR-seq mESC enhancer starr_31145 Neighboring gene STARR-positive B cell enhancer mm9_chr11:114966559-114966859 Neighboring gene STARR-positive B cell enhancer mm9_chr11:114967952-114968253 Neighboring gene RAB37, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E11499 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115019296-115019604 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115024157-115024344 Neighboring gene STARR-positive B cell enhancer ABC_E91 Neighboring gene NHERF family PDZ scaffold protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr11:115048516-115048817 Neighboring gene transmembrane protein 104 Neighboring gene N-acetyltransferase 9 (GCN5-related, putative)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline. Evans F, et al. Cell Rep, 2023 Oct 31. PMID 37864797
  2. An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. Izawa K, et al. J Immunol, 2009 Jul 15. PMID 19561101
  3. DIgR2, dendritic cell-derived immunoglobulin receptor 2, is one representative of a family of IgSF inhibitory receptors and mediates negative regulation of dendritic cell-initiated antigen-specific T-cell responses. Shi L, et al. Blood, 2006 Oct 15. PMID 16794255
  4. Caspase-independent cell death by CD300LF (MAIR-V), an inhibitory immunoglobulin-like receptor on myeloid cells. Can I, et al. J Immunol, 2008 Jan 1. PMID 18097021
  5. CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner. Furlong K, et al. J Virol, 2020 Aug 17. PMID 32581099, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased hippocampal excitability in miR-324-null mice.
    Title: Increased hippocampal excitability in miR-324-null mice.
  2. CD300f is a potential therapeutic target for the treatment of food allergy.
    Title: CD300f is a potential therapeutic target for the treatment of food allergy.
  3. Expression of CD300lf by microglia contributes to resistance to cerebral malaria by impeding the neuroinflammation.
    Title: Expression of CD300lf by microglia contributes to resistance to cerebral malaria by impeding the neuroinflammation.
  4. CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner.
    Title: CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner.
  5. Differential Lipid Recognition by Mouse versus Human CD300f, Inhibiting Passive Cutaneous Anaphylaxis, Depends on a Single Amino Acid Substitution in its Immunoglobulin-Like Domain.
    Title: Differential Lipid Recognition by Mouse versus Human CD300f, Inhibiting Passive Cutaneous Anaphylaxis, Depends on a Single Amino Acid Substitution in its Immunoglobulin-Like Domain.
  6. Loss of CD300f is associated with major depressive disorder and decreased microglial metabolic fitness.
    Title: CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness.
  7. LMIR3-knockout neutrophils displayed significantly augmented cytotoxic activity against P. aeruginosa and C. albicans. LMIR3 expression increased in response to infection in a TLR4/MyD88-dependent manner.
    Title: Mouse LIMR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils.
  8. Although the serine palmitoyltransferase complex is dispensable for the surface expression of the norovirus receptor (CD300lf), enzyme activity is required for CD300lf to adopt a conformation permissive for viral binding. Addition of extracellular ceramide to serine palmitoyltransferase-deficient cells complements both the conformational changes of CD300lf and the cellular susceptibility to murine norovirus infection.
    Title: Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection.
  9. the ceramide-CD300f interaction inhibits neutrophil recruitment to the sites of Gram-negative bacterial skin infections in mice.
    Title: Role of the Ceramide-CD300f Interaction in Gram-Negative Bacterial Skin Infections.
  10. These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils.
    Title: CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ceramide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ceramide binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-4 receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables virus receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in TRIF-dependent toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in TRIF-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in immune response-activating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-13-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MyD88-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mast cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within osteoclast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic cell clearance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-4-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CMRF35-like molecule 1
Names
CD300 antigen like family member F
CMRF-35-like molecule 1
DC-derived Ig-like receptor 2
MAIR-5
MAIR-V
leukocyte mono-Ig-like receptor 3
myeloid-associated immunoglobulin-like receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001169153.1 → NP_001162624.1  CMRF35-like molecule 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001162624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AI414341, AK089313, BM227747, CK790587
    Consensus CDS
    CCDS48980.1
    UniProtKB/Swiss-Prot
    A2A6Z1, A2A6Z3, Q6PEU7, Q6SJQ7, Q8K4V9
    UniProtKB/TrEMBL
    A0A1C9ZQ14
    Related
    ENSMUSP00000102171.2, ENSMUST00000106561.8
    Conserved Domains (3) summary
    cd05716
    Location:28 → 125
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:26 → 109
    IG_like; Immunoglobulin like
    pfam15330
    Location:213 → 299
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

  2. NM_001347648.1 → NP_001334577.1  CMRF35-like molecule 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL606487
    Consensus CDS
    CCDS83925.1
    UniProtKB/TrEMBL
    A2A6Z2
    Related
    ENSMUSP00000102172.3, ENSMUST00000106562.3

  3. NM_145634.3 → NP_663609.2  CMRF35-like molecule 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_663609.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI414341, AK089313, BM227747, CK790587
    Consensus CDS
    CCDS25619.1
    UniProtKB/Swiss-Prot
    Q6SJQ7
    Related
    ENSMUSP00000053983.8, ENSMUST00000051264.14
    Conserved Domains (2) summary
    pfam15330
    Location:206 → 292
    SIT; SHP2-interacting transmembrane adaptor protein, SIT
    cd05716
    Location:24 → 125
    IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115007040..115024834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314554.2 → XP_017170043.1  CMRF35-like molecule 1 isoform X1

    Conserved Domains (2) summary
    cd05716
    Location:28 → 125
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
    pfam15330
    Location:191 → 277
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

RNA

  1. XR_004936962.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6SJQ7.1 GenPept UniProtKB/Swiss-Prot:Q6SJQ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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