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Ggta1 glycoprotein alpha-galactosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246766, updated on 17-Aug-2024

Summary

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Official Symbol
Ggta1provided by RGD
Official Full Name
glycoprotein alpha-galactosyltransferase 1provided by RGD
Primary source
RGD:629476
See related
EnsemblRapid:ENSRNOG00000019179 AllianceGenome:RGD:629476
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ggta1p
Summary
Predicted to enable glycosyltransferase activity. Involved in protein galactosylation at cell surface. Located in Golgi cisterna. Orthologous to human GGTA1 (glycoprotein alpha-galactosyltransferase 1 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 234.3), Spleen (RPKM 179.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ggta1 in Genome Data Viewer
Location:
3p11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (39130466..39208652, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (18732985..18824916, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (14614099..14701185, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930402F06 gene like Neighboring gene spermidine synthase-like Neighboring gene uncharacterized LOC120101529 Neighboring gene uncharacterized LOC120101530 Neighboring gene uncharacterized LOC102549213 Neighboring gene uncharacterized LOC120101531

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enzymes that synthesize the IB4 epitope are not sufficient to impart IB4 binding in dorsal root ganglia of rat. Fullmer JM, et al. J Comp Neurol, 2007 Mar 1. PMID 17206613
  2. Characterization of the rat alpha(1,3)galactosyltransferase: evidence for two independent genes encoding glycosyltransferases that synthesize Galalpha(1,3)Gal by two separate glycosylation pathways. Taylor SG, et al. Glycobiology, 2003 May. PMID 12626403
  3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetyllactosaminide 3-alpha-galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in lipid glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-acetyllactosaminide alpha-1,3-galactosyltransferase
Names
UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase
galactosyltransferase
glycoprotein galactosyltransferase alpha 1, 3
glycoprotein, alpha-galactosyltransferase 1,3
NP_663707.1
XP_006234095.1
XP_006234099.1
XP_008759922.1
XP_008759924.1
XP_017446957.1
XP_017446958.1
XP_017446959.1
XP_038960200.1
XP_038960201.1
XP_038960202.1
XP_038960203.1
XP_038960204.1
XP_038960206.1
XP_038960207.1
XP_063139165.1
XP_063139166.1
XP_063139167.1
XP_063139168.1
XP_063139169.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145674.1 → NP_663707.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase

    See identical proteins and their annotated locations for NP_663707.1

    Status: PROVISIONAL

    Source sequence(s)
    AF520589
    UniProtKB/Swiss-Prot
    Q3L7M0, Q80WF5, Q8K3Z1
    UniProtKB/TrEMBL
    A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:86 → 369
    Glyco_transf_6; Glycosyltransferase family 6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    39130466..39208652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591470.3 → XP_017446959.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

    UniProtKB/TrEMBL
    A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:27 → 310
    Glyco_transf_6; Glycosyltransferase family 6

  2. XM_008761702.4 → XP_008759924.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X2

    See identical proteins and their annotated locations for XP_008759924.1

    UniProtKB/TrEMBL
    A0A0H2UHR0, A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:52 → 335
    Glyco_transf_6; Glycosyltransferase family 6

  3. XM_006234033.5 → XP_006234095.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006234095.1

    UniProtKB/Swiss-Prot
    Q3L7M0, Q80WF5, Q8K3Z1
    UniProtKB/TrEMBL
    A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:86 → 369
    Glyco_transf_6; Glycosyltransferase family 6

  4. XM_039104273.2 → XP_038960201.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q3L7M0, Q80WF5, Q8K3Z1
    UniProtKB/TrEMBL
    A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:86 → 369
    Glyco_transf_6; Glycosyltransferase family 6

  5. XM_008761700.4 → XP_008759922.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    See identical proteins and their annotated locations for XP_008759922.1

    UniProtKB/Swiss-Prot
    Q3L7M0, Q80WF5, Q8K3Z1
    UniProtKB/TrEMBL
    A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:86 → 369
    Glyco_transf_6; Glycosyltransferase family 6

  6. XM_063283097.1 → XP_063139167.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

    UniProtKB/TrEMBL
    A0A8I6AAD2

  7. XM_039104278.2 → XP_038960206.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHR0, A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:52 → 335
    Glyco_transf_6; Glycosyltransferase family 6

  8. XM_039104274.2 → XP_038960202.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q3L7M0, Q80WF5, Q8K3Z1
    UniProtKB/TrEMBL
    A0A8I6AAD2
    Related
    ENSRNOP00000025983.5, ENSRNOT00000025983.6
    Conserved Domains (1) summary
    pfam03414
    Location:86 → 369
    Glyco_transf_6; Glycosyltransferase family 6

  9. XM_017591468.3 → XP_017446957.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q3L7M0, Q80WF5, Q8K3Z1
    UniProtKB/TrEMBL
    A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:86 → 369
    Glyco_transf_6; Glycosyltransferase family 6

  10. XM_063283099.1 → XP_063139169.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

    UniProtKB/TrEMBL
    A0A8I6AAD2

  11. XM_039104275.2 → XP_038960203.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q3L7M0, Q80WF5, Q8K3Z1
    UniProtKB/TrEMBL
    A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:86 → 369
    Glyco_transf_6; Glycosyltransferase family 6

  12. XM_063283098.1 → XP_063139168.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

    UniProtKB/TrEMBL
    A0A8I6AAD2

  13. XM_063283096.1 → XP_063139166.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHR0, A0A8I6AAD2

  14. XM_039104272.2 → XP_038960200.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q3L7M0, Q80WF5, Q8K3Z1
    UniProtKB/TrEMBL
    A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:86 → 369
    Glyco_transf_6; Glycosyltransferase family 6

  15. XM_063283095.1 → XP_063139165.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHR0, A0A8I6AAD2

  16. XM_017591469.3 → XP_017446958.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q3L7M0, Q80WF5, Q8K3Z1
    UniProtKB/TrEMBL
    A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:86 → 369
    Glyco_transf_6; Glycosyltransferase family 6

  17. XM_039104276.2 → XP_038960204.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q3L7M0, Q80WF5, Q8K3Z1
    UniProtKB/TrEMBL
    A0A8I6AAD2
    Related
    ENSRNOP00000083720.1, ENSRNOT00000107236.2
    Conserved Domains (1) summary
    pfam03414
    Location:86 → 369
    Glyco_transf_6; Glycosyltransferase family 6

  18. XM_039104279.2 → XP_038960207.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

    UniProtKB/TrEMBL
    A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:27 → 310
    Glyco_transf_6; Glycosyltransferase family 6

  19. XM_006234037.5 → XP_006234099.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006234099.1

    UniProtKB/Swiss-Prot
    Q3L7M0, Q80WF5, Q8K3Z1
    UniProtKB/TrEMBL
    A0A8I6AAD2
    Conserved Domains (1) summary
    pfam03414
    Location:86 → 369
    Glyco_transf_6; Glycosyltransferase family 6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3L7M0.2 GenPept UniProtKB/Swiss-Prot:Q3L7M0

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