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Prph peripherin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24688, updated on 17-Aug-2024

Summary

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Official Symbol
Prphprovided by RGD
Official Full Name
peripherinprovided by RGD
Primary source
RGD:3414
See related
EnsemblRapid:ENSRNOG00000052880 AllianceGenome:RGD:3414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Perf; Prph1
Summary
Predicted to enable structural molecule activity. Involved in intermediate filament cytoskeleton organization. Located in neuronal cell body; terminal bouton; and type III intermediate filament. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 1. Orthologous to human PRPH (peripherin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 34.2), Brain (RPKM 24.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prph in Genome Data Viewer
Location:
7q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132096888..132101070)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130218149..130222136)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140742406..140746197)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C Neighboring gene uncharacterized LOC120093830 Neighboring gene uncharacterized LOC102546594 Neighboring gene trophinin associated protein Neighboring gene complement C1q like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. New insights into peripherin expression in cochlear neurons. Lallemend F, et al. Neuroscience, 2007 Nov 30. PMID 17964735
  2. Tyrosine nitration is a novel post-translational modification occurring on the neural intermediate filament protein peripherin. Tedeschi G, et al. Neurochem Res, 2007 Mar. PMID 17268851
  3. Peripherin immunoreactivity labels small diameter vestibular 'bouton' afferents in rodents. Lysakowski A, et al. Hear Res, 1999 Jul. PMID 10416873, Free PMC Article
  4. Translation initiation and assembly of peripherin in cultured cells. Ho CL, et al. Eur J Cell Biol, 1995 Oct. PMID 8575457
  5. Relationship between the nerve growth factor-regulated clone 73 gene product and the 58-kilodalton neuronal intermediate filament protein (peripherin). Aletta JM, et al. J Neurochem, 1988 Oct. PMID 3418352

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonistrated that differential expression of peripherin and NF-H after injury occurs in both cutaneous and muscular afferent neurons after injury.
    Title: Peripherin and ATF3 genes are differentially regulated in regenerating and non-regenerating primary sensory neurons.
  2. Using a morphological approach that peripherin expression in subpopulations within the dorsal root ganglia sensory neurons. And peripherin is specifically expressed in unmyelinated fibers.
    Title: Neuronal intermediate filament expression in rat dorsal root ganglia sensory neurons: an in vivo and in vitro study.
  3. By birth, and for 2 or 3 days, peripherin expression was gradually restricted to the type II neuronal population and their projections.
    Title: New insights into peripherin expression in cochlear neurons.
  4. peripherin is a novel substrate for Akt in vivo and its phosphorylation may play a role in motor nerve regeneration
    Title: Identification of peripherin as a Akt substrate in neurons.
  5. Peripherin nitration is not restricted to PC12 cells but it is also present in vivo in rat brain.
    Title: Tyrosine nitration is a novel post-translational modification occurring on the neural intermediate filament protein peripherin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intermediate filament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intermediate filament cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in C-fiber ISO
Inferred from Sequence Orthology
more info
  
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
  
located_in neurofilament ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor outer segment membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
  
is_active_in type III intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in type III intermediate filament IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
peripherin
Names
peripherin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012633.3 → NP_036765.3  peripherin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P21807
    UniProtKB/TrEMBL
    A6KCD5
    Related
    ENSRNOP00000072008.2, ENSRNOT00000089211.3
    Conserved Domains (2) summary
    pfam00038
    Location:99 → 409
    Filament; Intermediate filament protein
    pfam04732
    Location:21 → 98
    Filament_head; Intermediate filament head (DNA binding) region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    132096888..132101070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765669.4 → XP_008763891.1  peripherin isoform X2

    UniProtKB/TrEMBL
    A0A8I6AT59, Q496Z5
    Conserved Domains (2) summary
    pfam00038
    Location:99 → 441
    Filament; Intermediate filament protein
    pfam04732
    Location:21 → 98
    Filament_head; Intermediate filament head (DNA binding) region

  2. XM_006257321.5 → XP_006257383.1  peripherin isoform X1

    See identical proteins and their annotated locations for XP_006257383.1

    UniProtKB/Swiss-Prot
    P21807
    UniProtKB/TrEMBL
    A6KCD4
    Related
    ENSRNOP00000097710.2, ENSRNOT00000094354.2
    Conserved Domains (2) summary
    pfam00038
    Location:99 → 441
    Filament; Intermediate filament protein
    pfam04732
    Location:21 → 98
    Filament_head; Intermediate filament head (DNA binding) region

  3. XM_063262998.1 → XP_063119068.1  peripherin isoform X3

    UniProtKB/TrEMBL
    F1M7P4, Q496Z5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21807.1 GenPept UniProtKB/Swiss-Prot:P21807

Gene LinkOut

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