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Ccl2 C-C motif chemokine ligand 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24770, updated on 28-Oct-2024

Summary

Official Symbol
Ccl2provided by RGD
Official Full Name
C-C motif chemokine ligand 2provided by RGD
Primary source
RGD:3645
See related
EnsemblRapid:ENSRNOG00000007159 AllianceGenome:RGD:3645
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MCP-1; Scya2; Sigje
Summary
Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of leukocyte migration. Located in several cellular components, including axon; perikaryon; and perinuclear region of cytoplasm. Used to study several diseases, including artery disease (multiple); diabetic angiopathy; interstitial lung disease (multiple); kidney disease (multiple); and pancreatitis (multiple). Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); liver disease (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); end stage renal disease; and gastrointestinal system cancer (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Heart (RPKM 80.6), Kidney (RPKM 64.7) and 8 other tissues See more
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Genomic context

See Ccl2 in Genome Data Viewer
Location:
10q26
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (67503077..67504875)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67005424..67007222)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (69412065..69413863)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene acid sensing ion channel subunit 2 Neighboring gene uncharacterized LOC108352208 Neighboring gene uncharacterized LOC134480836 Neighboring gene C-C motif chemokine ligand 11 Neighboring gene C-C motif chemokine ligand 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables CCR2 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine activity NAS
Non-traceable Author Statement
more info
PubMed 
enables chemokine activity TAS
Traceable Author Statement
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in astrocyte cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ATP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to high density lipoprotein particle stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-6 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipoprotein particle stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to macrophage colony-stimulating factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to platelet-derived growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to type II interferon IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chemokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemokinesis TAS
Traceable Author Statement
more info
PubMed 
involved_in chronic inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in eosinophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in helper T cell extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte migration involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in macrophage chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in mammary gland involution IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in maternal process involved in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in maternal process involved in parturition IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of natural killer cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoclast differentiation HEP PubMed 
involved_in positive regulation of NMDA glutamate receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cellular extravasation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of collagen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immune complex clearance by monocytes and macrophages ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein targeting to membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cyclosporin A IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to gamma radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to isolation stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin B3 IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to wounding ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in C-fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
C-C motif chemokine 2
Names
chemokine (C-C motif) ligand 2
immediate-early serum-responsive JE protein
immediate-early serum-responsive protein JE
monocyte chemoattractant protein 1
monocyte chemotactic protein 1
small inducible cytokine A2
small inducible gene JE

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031530.1NP_113718.1  C-C motif chemokine 2 precursor

    See identical proteins and their annotated locations for NP_113718.1

    Status: PROVISIONAL

    Source sequence(s)
    AF058786
    UniProtKB/Swiss-Prot
    P14844, Q549R5
    UniProtKB/TrEMBL
    A6HHD2
    Related
    ENSRNOP00000009448.1, ENSRNOT00000009448.5
    Conserved Domains (1) summary
    smart00199
    Location:3190
    SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    67503077..67504875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)