Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpina3nprovided by RGD
Official Full Name: serine (or cysteine) peptidase inhibitor, clade A, member 3Nprovided by RGD
Primary source: RGD:3747
See related: EnsemblRapid:ENSRNOG00000029949 AllianceGenome:RGD:3747
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SPI3; Spin3; CPi-26; Spin2c; Spi-2.2
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to organic cyclic compound; and response to vitamin B6. Located in extracellular space. Used to study adult respiratory distress syndrome. Biomarker of uveitis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 4717.5) See more
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Genomic context

Location:: 6q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (129088392..129095950)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (123323623..123331181)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (128073344..128080878)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
Title: The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
The sequence of HM448398 was highly homologous to that of rat Serpina3n, suggesting that it may be a homolog of Serpina3n.
Title: Cloning and prokaryotic expression of rat homolog of Serpina3n and its expression change during liver regeneration.
SPI-3 may be involved during early events of modulating the activities of serine proteases following nerve injury.
Title: Peripheral nerve injury induced expression of mRNA for serine protease inhibitor 3 in the rat facial and hypoglossal nuclei but not in the spinal cord.

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General gene information

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Markers

RH142440 (e-PCR)
- UniSTS:231687

RH128585 (e-PCR)
- UniSTS:211893

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-6	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to peptide hormone	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin B6	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine protease inhibitor A3N

Names: SPI-3; contrapsin-like protease inhibitor 6; serine protease inhibitor 2c; serine protease inhibitor 3; serpin A3N; serpina3n-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031531.3 → NP_113719.3 serine protease inhibitor A3N precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P09006, Q03312

UniProtKB/TrEMBL

A0A0H2UHI5, A6JEQ8

Related

ENSRNOP00000014073.5, ENSRNOT00000014073.7

Conserved Domains (1) summary

cd19551
Location:37 → 418

serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin