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Tg thyroglobulin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24826, updated on 17-Aug-2024

Summary

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Symbol
Tgprovided by RGD
Full Name
thyroglobulinprovided by RGD
Primary source
RGD:3848
See related
EnsemblRapid:ENSRNOG00000082126 AllianceGenome:RGD:3848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tgn
Summary
Enables several functions, including anion binding activity; chaperone binding activity; and identical protein binding activity. Involved in several processes, including response to lipopolysaccharide; thyroid hormone generation; and transcytosis. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study hypothyroidism and isolated growth hormone deficiency. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; goiter; and thyroid dyshormonogenesis 3. Orthologous to human TG (thyroglobulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 16.1), Kidney (RPKM 5.4) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q33
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (100307349..100492246)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (98418293..98603210)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (107467260..107652897)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene PHD finger protein 20-like 1 Neighboring gene U2 spliceosomal RNA Neighboring gene src-like adaptor Neighboring gene cellular communication network factor 4 Neighboring gene N-myc downstream regulated 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. p.L571P in the linker domain of rat thyroglobulin causes intracellular retention. Citterio CE, et al. Mol Cell Endocrinol, 2020 Apr 5. PMID 31972331
  2. A novel mutation in the thyroglobulin gene that causes goiter and dwarfism in Wistar Hannover GALAS rats. Sato A, et al. Mutat Res, 2014 Apr. PMID 24582622
  3. Thyroglobulin increases thyroid cell proliferation via the suppression of specific microRNAs. Akama T, et al. Mol Endocrinol, 2014 Mar. PMID 24479877, Free PMC Article
  4. cDNA immunization of mice with human thyroglobulin generates both humoral and T cell responses: a novel model of thyroid autoimmunity. Jacobson EM, et al. PLoS One, 2011 Apr 29. PMID 21559421, Free PMC Article
  5. Differential regulation of apical and basal iodide transporters in the thyroid by thyroglobulin. Suzuki K, et al. J Endocrinol, 2006 May. PMID 16648292

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The p.Pro2232Leu variant in the ChEL domain of thyroglobulin gene causes intracellular transport disorder and congenital hypothyroidism.
    Title: The p.Pro2232Leu variant in the ChEL domain of thyroglobulin gene causes intracellular transport disorder and congenital hypothyroidism.
  2. Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood.
    Title: Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood.
  3. p.L571P in the linker domain of rat thyroglobulin causes intracellular retention.
    Title: p.L571P in the linker domain of rat thyroglobulin causes intracellular retention.
  4. SREBP1c and SREBP2 are transcriptional regulators of the thyroglobulin gene in thyroid cells.
    Title: Sterol regulatory element-binding proteins are transcriptional regulators of the thyroglobulin gene in thyroid cells.
  5. cathepsin H is an active participant in lysosome-mediated pre-hormone degradation, and follicular Tg stimulates mobilization of pre-hormones by activating cathepsin H-associated proteolysis pathways
    Title: Follicular thyroglobulin induces cathepsin H expression and activity in thyrocytes.
  6. Rab7 regulates CDH1 endocytosis, circular dorsal ruffles genesis, and thyroglobulin pinocytosis in a thyroid cell line.
    Title: Rab7 Regulates CDH1 Endocytosis, Circular Dorsal Ruffles Genesis, and Thyroglobulin Internalization in a Thyroid Cell Line.
  7. Tg possesses unique means of regulating cell proliferation that are dependent on miR-24 and that could conceivably be involved in the autoregulation of thyroid function by Tg.
    Title: Thyroglobulin increases thyroid cell proliferation via the suppression of specific microRNAs.
  8. A novel mutation in the thyroglobulin gene that causes goiter and dwarfism in Wistar Hannover GALAS rats.
    Title: A novel mutation in the thyroglobulin gene that causes goiter and dwarfism in Wistar Hannover GALAS rats.
  9. Aammonium perchlorate can decrease the mRNA expression levels of Tg and TPO in the thyroid.
    Title: [The effects of ammonium perchlorate on thyroid function and mRNA expression of thyroglobulin and thyroperoxidase].
  10. Compared with the control group, the TPO mRNA levels of the propylthiouracil-treated group were increased, while the Tg mRNA levels were decreased significantly.
    Title: [Effect of PTU on the expression of thyroid TPO, Tg mRNA in rats].
Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables anion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to genistein IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in iodide transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within iodide transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myelination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to pH IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in thyroid gland development IEA
Inferred from Electronic Annotation
more info
  
involved_in thyroid gland development ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone generation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thyroid hormone generation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thyroid hormone generation IEA
Inferred from Electronic Annotation
more info
  
involved_in thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone generation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within thyroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in transcytosis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space TAS
Traceable Author Statement
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thyroglobulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270783.1 → NP_001257712.1  thyroglobulin isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2JXY8, G5ENA7
    Conserved Domains (5) summary
    smart00211
    Location:1471 → 1518
    TY; Thyroglobulin type I repeats
    cd00191
    Location:96 → 161
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00135
    Location:2150 → 2671
    COesterase; Carboxylesterase family
    pfam07699
    Location:1416 → 1461
    GCC2_GCC3; GCC2 and GCC3
    cl00150
    Location:682 → 728
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

  2. NM_001270784.1 → NP_001257713.1  thyroglobulin isoform 3 precursor

    See identical proteins and their annotated locations for NP_001257713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) consists of only the first five exons plus an alternate 3' exon compared to variant 1. The resulting isoform (3) has a much shorter and distinct C-terminus compared to isoform 1. This variant has been described in PMID:2325666.
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6AAP3, A6HRR7
    Related
    ENSRNOP00000089860.1, ENSRNOT00000083264.4
    Conserved Domains (1) summary
    cd00191
    Location:96 → 161
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

  3. NM_030988.2 → NP_112250.2  thyroglobulin isoform 1 precursor

    See identical proteins and their annotated locations for NP_112250.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P06882, Q9JKY6, Q9JM94
    UniProtKB/TrEMBL
    A6HRR6, G3V6V3
    Conserved Domains (5) summary
    smart00211
    Location:1519 → 1566
    TY; Thyroglobulin type I repeats
    cd00191
    Location:96 → 161
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00135
    Location:2198 → 2719
    COesterase; Carboxylesterase family
    pfam07699
    Location:1464 → 1509
    GCC2_GCC3; GCC2 and GCC3
    cl00150
    Location:164 → 249
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    100307349..100492246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06882.4 GenPept UniProtKB/Swiss-Prot:P06882

Gene LinkOut

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