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Klkb1 kallikrein B1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25048, updated on 2-Nov-2024

Summary

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Official Symbol
Klkb1provided by RGD
Official Full Name
kallikrein B1provided by RGD
Primary source
RGD:67382
See related
EnsemblRapid:ENSRNOG00000014118 AllianceGenome:RGD:67382
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PK; Klk3; Kalp1; KALP15
Summary
Predicted to enable serine-type endopeptidase activity. Involved in liver regeneration. Located in extracellular space. Used to study inflammatory bowel disease. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in lupus nephritis and systemic lupus erythematosus. Orthologous to human KLKB1 (kallikrein B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 700.7), Adrenal (RPKM 144.3) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klkb1 in Genome Data Viewer
Location:
16q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (53690180..53714570)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (46958634..46982054)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (50151127..50175407)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily v, polypeptide 3 Neighboring gene tubulin, alpha 1B, pseudogene 9 Neighboring gene coagulation factor XI Neighboring gene small ribosomal subunit protein eS26-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats. Guan J, et al. Transl Stroke Res, 2022 Apr. PMID 34241810, Free PMC Article
  2. PF-04886847 (an inhibitor of plasma kallikrein) attenuates inflammatory mediators and activation of blood coagulation in rat model of lipopolysaccharide (LPS)-induced sepsis. Kolte D, et al. Cardiovasc Hematol Agents Med Chem, 2012 Jun. PMID 22352684, Free PMC Article
  3. [Evaluation of protein compliance in patients with chronic renal insufficiency undergoing hemodialysis treatment]. Pace V, et al. Riv Eur Sci Med Farmacol, 1992 May-Jun. PMID 1298973
  4. Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. Liu K, et al. J Clin Invest, 2009 Apr. PMID 19307730, Free PMC Article
  5. Changes in plasma prekallikrein activity, blood pressure, and left ventricular thickness in hypertensive and normotensive diabetic rats. Sharma JN, et al. Methods Find Exp Clin Pharmacol, 2007 Mar. PMID 17440623

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats.
    Title: Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats.
  2. findings suggest for the first time that higher plasma prekallikrein activity may serve as an indicator for predicting high BP and left ventricular hypertrophy in diabetic and hypertensive conditions
    Title: Changes in plasma prekallikrein activity, blood pressure, and left ventricular thickness in hypertensive and normotensive diabetic rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC108748

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
  
involved_in fibrinolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in plasminogen activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
plasma kallikrein
Names
fletcher factor
kallikrein B, plasma 1
kininogenin
plasma prekallikrein
NP_036857.2
XP_006253183.1
XP_008769475.2
XP_063131126.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012725.2 → NP_036857.2  plasma kallikrein precursor

    See identical proteins and their annotated locations for NP_036857.2

    Status: PROVISIONAL

    Source sequence(s)
    BC089815
    UniProtKB/Swiss-Prot
    P14272
    UniProtKB/TrEMBL
    A6JPR7, F7FQ32, Q5FVS2
    Related
    ENSRNOP00000019237.3, ENSRNOT00000019237.7
    Conserved Domains (3) summary
    smart00223
    Location:21 → 104
    APPLE; APPLE domain
    smart00020
    Location:390 → 621
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:391 → 621
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    53690180..53714570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253121.5 → XP_006253183.1  plasma kallikrein isoform X1

    UniProtKB/Swiss-Prot
    P14272
    Conserved Domains (3) summary
    smart00223
    Location:21 → 104
    APPLE; APPLE domain
    smart00020
    Location:377 → 608
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:378 → 608
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_063275056.1 → XP_063131126.1  plasma kallikrein isoform X2

  3. XM_008771253.3 → XP_008769475.2  plasma kallikrein isoform X3

    UniProtKB/TrEMBL
    A6JPR8
    Related
    ENSRNOP00000108529.1, ENSRNOT00000121109.1
    Conserved Domains (3) summary
    smart00223
    Location:49 → 132
    APPLE; APPLE domain
    cd00190
    Location:329 → 559
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl00112
    Location:14 → 42
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14272.1 GenPept UniProtKB/Swiss-Prot:P14272

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