Slc2a4 solute carrier family 2 member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc2a4provided by RGD
Official Full Name: solute carrier family 2 member 4provided by RGD
Primary source: RGD:2711
See related: EnsemblRapid:ENSRNOG00000017226 AllianceGenome:RGD:2711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Glut4
Summary: Enables D-glucose transmembrane transporter activity. Involved in several processes, including glucose import in response to insulin stimulus; regulation of synaptic vesicle budding from presynaptic endocytic zone membrane; and response to ethanol. Acts upstream of or within with a positive effect on long-term memory. Acts upstream of or within with a negative effect on short-term memory. Acts upstream of or within learning or memory and positive regulation of brain-derived neurotrophic factor receptor signaling pathway. Located in several cellular components, including T-tubule; clathrin-coated pit; and cytoplasmic vesicle. Is active in presynapse. Colocalizes with vesicle. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 955.0), Heart (RPKM 746.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55164721..55170289, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54666015..54671581, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56552921..56558562, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impact of Normal and Overweight Pregnancy in GLUT4 and Glucose-Dependent Vascular Contractility.
Title: Impact of Normal and Overweight Pregnancy in GLUT4 and Glucose-Dependent Vascular Contractility.
Exercise preconditioning promotes myocardial GLUT4 translocation and induces autophagy to alleviate exhaustive exercise-induced myocardial injury in rats.
Title: Exercise preconditioning promotes myocardial GLUT4 translocation and induces autophagy to alleviate exhaustive exercise-induced myocardial injury in rats.
Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle.
Title: Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle.
Electrical stimulated GLUT4 signalling attenuates critical illness-associated muscle wasting.
Title: Electrical stimulated GLUT4 signalling attenuates critical illness-associated muscle wasting.
Effect of resistance training on osteopenic rat bones in neonatal streptozotocin-induced diabetes: Analysis of GLUT4 content and biochemical, biomechanical, densitometric, and microstructural evaluation.
Title: Effect of resistance training on osteopenic rat bones in neonatal streptozotocin-induced diabetes: Analysis of GLUT4 content and biochemical, biomechanical, densitometric, and microstructural evaluation.
Prolonged preoperative fasting induces postoperative insulin resistance by ER-stress mediated Glut4 down-regulation in skeletal muscles.
Title: Prolonged preoperative fasting induces postoperative insulin resistance by ER-stress mediated Glut4 down-regulation in skeletal muscles.
Hydroxytyrosol modifies skeletal muscle GLUT4/AKT/Rac1 axis in trained rats.
Title: Hydroxytyrosol modifies skeletal muscle GLUT4/AKT/Rac1 axis in trained rats.
Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT-2/4 and AKT signaling pathway in streptozotocin-induced diabetic rats.
Title: Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT-2/4 and AKT signaling pathway in streptozotocin-induced diabetic rats.
Gundelia tournefortii: Fractionation, Chemical Composition and GLUT4 Translocation Enhancement in Muscle Cell Line.
Title: Gundelia tournefortii: Fractionation, Chemical Composition and GLUT4 Translocation Enhancement in Muscle Cell Line.
Adaptations in GLUT4 Expression in Response to Exercise Detraining Linked to Downregulation of Insulin-Dependent Pathways in Cardiac but not in Skeletal Muscle Tissue.
Title: Adaptations in GLUT4 Expression in Response to Exercise Detraining Linked to Downregulation of Insulin-Dependent Pathways in Cardiac but not in Skeletal Muscle Tissue.

Submit: New GeneRIF Correction See all GeneRIFs (215)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:547075

Slc2a4 (e-PCR), detects polymorphism
- UniSTS:547075

Slc2a4 (e-PCR), detects polymorphism
- UniSTS:144427

D10Wox39 (e-PCR)
- UniSTS:519008

D10Wox39 (e-PCR)
- UniSTS:239242

D10Wox40 (e-PCR)
- UniSTS:239252

SLC2A4_1783 (e-PCR)
- UniSTS:281018

D10Uwm1 (e-PCR)
- UniSTS:239613

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glucose transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glucose uniporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within amylopectin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to osmotic stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose import	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose import in response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucose import in response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in glucose import in response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in glucose import in response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glucose transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_positive_effect long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of brain-derived neurotrophic factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within_negative_effect short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in insulin-responsive compartment	IDA Inferred from Direct Assay more info	PubMed
located_in insulin-responsive compartment	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network transport vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 4

Names: GLUT-4; Glucose transporter 4, insuline-responsive; glucose transporter 4 insulin-responsive; glucose transporter type 4, insulin-responsive; insulin responsive glucose transporter; solute carrier family 2 (facilitated glucose transporter), member 4; solute carrier family 2 , member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430054.1 → NP_001416983.1 solute carrier family 2, facilitated glucose transporter member 4 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P19357, P97900

UniProtKB/TrEMBL

A0A8I6B1R2, A6HFY2
NM_001430055.1 → NP_001416984.1 solute carrier family 2, facilitated glucose transporter member 4 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6AM71
NM_012751.2 → NP_036883.1 solute carrier family 2, facilitated glucose transporter member 4 isoform a

See identical proteins and their annotated locations for NP_036883.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P19357, P97900

UniProtKB/TrEMBL

A0A8I6B1R2, A6HFY2

Related

ENSRNOP00000023256.3, ENSRNOT00000023256.7

Conserved Domains (2) summary

cd06174
Location:78 → 447

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:27 → 483

Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

55164721..55170289 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246596.5 → XP_006246658.1 solute carrier family 2, facilitated glucose transporter member 4 isoform X2

Conserved Domains (2) summary

cd06174
Location:78 → 447

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:27 → 483

Sugar_tr; Sugar (and other) transporter
XM_063268455.1 → XP_063124525.1 solute carrier family 2, facilitated glucose transporter member 4 isoform X1

UniProtKB/TrEMBL

A0A8I6AM71

Related

ENSRNOP00000090027.1, ENSRNOT00000095666.2