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Mas1 MAS1 proto-oncogene, G protein-coupled receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25153, updated on 2-Nov-2024

Summary

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Official Symbol
Mas1provided by RGD
Official Full Name
MAS1 proto-oncogene, G protein-coupled receptorprovided by RGD
Primary source
RGD:3049
See related
EnsemblRapid:ENSRNOG00000014971 AllianceGenome:RGD:3049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mgra; c-mas
Summary
Predicted to enable angiotensin receptor activity and peptide binding activity. Involved in several processes, including hippocampus development; positive regulation of DNA replication; and regulation of phosphate metabolic process. Located in cell surface. Used to study glaucoma and hypertension. Biomarker of chronic kidney disease; congestive heart failure; dilated cardiomyopathy; and primary biliary cholangitis. Orthologous to human MAS1 (MAS1 proto-oncogene, G protein-coupled receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 15.2), Heart (RPKM 5.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mas1 in Genome Data Viewer
Location:
1q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (50428064..50459537)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (47879956..47911500)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48076761..48108218)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene PARN like ribonuclease domain containing exonuclease 1 Neighboring gene MAS1 proto-oncogene like, G protein-coupled receptor Neighboring gene uncharacterized LOC120099123 Neighboring gene uncharacterized LOC134482693 Neighboring gene uncharacterized LOC134482699

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effects of angiotensin II on proximal tubular cells stably transfected with the c-mas oncogene. Wolf G, et al. Am J Physiol, 1992 Nov. PMID 1332507
  2. Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells. Ng HY, et al. PLoS One, 2014. PMID 24614509, Free PMC Article
  3. Angiotensin-(1-7) recruits muscle microvasculature and enhances insulin's metabolic action via mas receptor. Fu Z, et al. Hypertension, 2014 Jun. PMID 24711523, Free PMC Article
  4. G protein-coupled receptor MAS1 induces an inhibitory effect on myocardial infarction-induced myocardial injury. Zhou G, et al. Int J Biol Macromol, 2022 May 15. PMID 35247425
  5. Sex differences in the renal vascular response to angiotensin II involves the Mas receptor. Safari T, et al. Acta Physiol (Oxf), 2012 Oct. PMID 22775972

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. G protein-coupled receptor MAS1 induces an inhibitory effect on myocardial infarction-induced myocardial injury.
    Title: G protein-coupled receptor MAS1 induces an inhibitory effect on myocardial infarction-induced myocardial injury.
  2. Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats.
    Title: Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats.
  3. Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries.
    Title: Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries.
  4. Mas Receptor Activation Contributes to the Improvement of Nitric Oxide Bioavailability and Vascular Remodeling During Chronic AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension.
    Title: Mas Receptor Activation Contributes to the Improvement of Nitric Oxide Bioavailability and Vascular Remodeling During Chronic AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension.
  5. Secreted Monocyte miR-27a, via Mesenteric Arterial Mas Receptor-eNOS Pathway, Causes Hypertension.
    Title: Secreted Monocyte miR-27a, via Mesenteric Arterial Mas Receptor-eNOS Pathway, Causes Hypertension.
  6. TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor.
    Title: TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor.
  7. Data support the hypothesis that interaction between AT1R and Mas1 contributes to proangiogenic Ang-(1-7) signaling in the skeletal muscle.
    Title: Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats.
  8. Ang-(1-7) stimulates beige markers and thermogenesis via the Mas receptor.
    Title: Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor.
  9. Small molecule ligands modulate numerous G protein-dependent and independent pathways through MAS1.
    Title: Angiotensin (1-7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor.
  10. Renal AT1 receptor activation, as well as Mas receptor activation, plays an essential role in mediating Ang-(1-7)-induced natriuresis and diuresis.
    Title: Intrarenal Mas and AT(1) receptors play a role in mediating the excretory actions of renal interstitial angiotensin-(1-7) infusion in anaesthetized rats.
Submit: New GeneRIF Correction See all GeneRIFs (47)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables angiotensin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables angiotensin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to peptide hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in hippocampus development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating angiotensin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of inositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in response to activity IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to gonadotropin IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proto-oncogene Mas
Names
MAS proto-oncogene
MAS1 oncogene
Mas-related G protein-coupled receptor a
angiotensin-(1-7) receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012757.2 → NP_036889.1  proto-oncogene Mas

    See identical proteins and their annotated locations for NP_036889.1

    Status: VALIDATED

    Source sequence(s)
    BC078884
    UniProtKB/Swiss-Prot
    P12526
    UniProtKB/TrEMBL
    W8W3M4
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    50428064..50459537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281329.1 → XP_063137399.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    P12526
    UniProtKB/TrEMBL
    W8W3M4
    Related
    ENSRNOP00000020100.4, ENSRNOT00000020100.7

  2. XM_039101409.2 → XP_038957337.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    P12526
    UniProtKB/TrEMBL
    W8W3M4
    Related
    ENSRNOP00000097396.1, ENSRNOT00000104217.2
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_063281319.1 → XP_063137389.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    P12526
    UniProtKB/TrEMBL
    W8W3M4

  4. XM_063281307.1 → XP_063137377.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    P12526
    UniProtKB/TrEMBL
    W8W3M4

  5. XM_006227860.5 → XP_006227922.1  proto-oncogene Mas isoform X1

    See identical proteins and their annotated locations for XP_006227922.1

    UniProtKB/Swiss-Prot
    P12526
    UniProtKB/TrEMBL
    W8W3M4
    Related
    ENSRNOP00000104659.1, ENSRNOT00000132244.1
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. XM_039101408.2 → XP_038957336.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    P12526
    UniProtKB/TrEMBL
    W8W3M4
    Related
    ENSRNOP00000103225.1, ENSRNOT00000164553.1
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  7. XM_063281318.1 → XP_063137388.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    P12526
    UniProtKB/TrEMBL
    W8W3M4

  8. XM_039101416.2 → XP_038957344.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    P12526
    UniProtKB/TrEMBL
    W8W3M4
    Related
    ENSRNOP00000100641.1, ENSRNOT00000127520.1
    Conserved Domains (1) summary
    cd15110
    Location:32 → 306
    7tmA_MrgprH; mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors

  9. XM_063281312.1 → XP_063137382.1  proto-oncogene Mas isoform X1

    UniProtKB/Swiss-Prot
    P12526
    UniProtKB/TrEMBL
    W8W3M4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12526.1 GenPept UniProtKB/Swiss-Prot:P12526

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