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Zfp386 zinc finger protein 386 (Kruppel-like) [ Rattus norvegicus (Norway rat) ]

Gene ID: 25165, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp386provided by RGD
Official Full Name
zinc finger protein 386 (Kruppel-like)provided by RGD
Primary source
RGD:2985
See related
EnsemblRapid:ENSRNOG00000004268 AllianceGenome:RGD:2985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kzf1; Znf386
Summary
Enables double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and spermatogenesis. Predicted to be active in nucleus. Orthologous to human ZNF519 (zinc finger protein 519). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 123.0), Adrenal (RPKM 121.7) and 9 other tissues See more
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Genomic context

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See Zfp386 in Genome Data Viewer
Location:
6q33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (143109563..143124266)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (136966547..136984013)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (143901239..143915953)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy variable 2-70-like Neighboring gene Ig heavy chain V region 3-like Neighboring gene vasoactive intestinal peptide receptor 2 Neighboring gene chromatin target of PRMT1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Kzf1 - a novel KRAB zinc finger protein encoding gene expressed during rat spermatogenesis. Bellefroid EJ, et al. Biochim Biophys Acta, 1998 Jul 9. PMID 9655926
  2. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. Wang L, et al. Biochem Biophys Res Commun, 2004 Dec 3. PMID 15522233
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 386 (Kruppel-like)
Names
Kruppel associated box (KRAB) zinc finger 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019620.3 → NP_062566.3  zinc finger protein 386 (Kruppel-like)

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    Q6AYY1
    Related
    ENSRNOP00000070717.3, ENSRNOT00000091884.3
    Conserved Domains (4) summary
    COG5048
    Location:424 → 584
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:456 → 476
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:384 → 409
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    143109563..143124266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111798.2 → XP_038967726.1  zinc finger protein 386 (Kruppel-like) isoform X3

    Conserved Domains (1) summary
    smart00349
    Location:6 → 47
    KRAB; krueppel associated box

  2. XM_039111799.2 → XP_038967727.1  zinc finger protein 386 (Kruppel-like) isoform X4

    Conserved Domains (1) summary
    smart00349
    Location:6 → 49
    KRAB; krueppel associated box

  3. XM_063261557.1 → XP_063117627.1  zinc finger protein 386 (Kruppel-like) isoform X1

  4. XM_063261558.1 → XP_063117628.1  zinc finger protein 386 (Kruppel-like) isoform X2

  5. XM_039111797.2 → XP_038967725.1  zinc finger protein 386 (Kruppel-like) isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:327 → 487
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:359 → 379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:287 → 312
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_005505444.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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