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Jheh1 Juvenile hormone epoxide hydrolase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 251984, updated on 2-Nov-2024

Summary

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Official Symbol
Jheh1provided by FlyBase
Official Full Name
Juvenile hormone epoxide hydrolase 1provided by FlyBase
Primary source
FLYBASE:FBgn0010053
Locus tag
Dmel_CG15101
See related
AllianceGenome:FB:FBgn0010053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
142196_at; BEST:GH06241; CG15101; Dmel\CG15101; JH; Jheh; JHEH; JHEH 1; jheh1
Summary
Enables juvenile hormone epoxide hydrolase activity. Involved in juvenile hormone catabolic process. Is expressed in adult head; adult heart; embryonic/larval fat body; embryonic/larval midgut; and fat body/gonad primordium. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (epoxide hydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Jheh1 in Genome Data Viewer
Location:
55F7-55F8; 2-86 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18853434..18855087, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14740939..14742592, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Methionyl-tRNA synthetase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46485 Neighboring gene Juvenile hormone epoxide hydrolase 2 Neighboring gene Juvenile hormone epoxide hydrolase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fertility differences between two wild-type Drosophila melanogaster lines correlate with differences in the expression of the Jheh1 gene, which codes for an enzyme degrading juvenile hormone. Andreenkova OV, et al. Vavilovskii Zhurnal Genet Selektsii, 2024 Apr. PMID 38680182, Free PMC Article
  2. [Role of juvenile hormone metabolism in the adaptation of Drosophila populations to stressful environmental conditions]. Gruntenko NE, et al. Genetika, 1996 Sep. PMID 9026460
  3. A comparative analysis of juvenile hormone metabolyzing enzymes in two species of Drosophila during development. Khlebodarova TM, et al. Insect Biochem Mol Biol, 1996 Sep-Oct. PMID 9014329
  4. [Genetic control of juvenile hormone metabolism in Drosophila melanogaster]. Gruntenko NE, et al. Genetika, 1996 Feb. PMID 8713622
  5. Reversible juvenile hormone inhibition of ecdysteroid and juvenile hormone synthesis by the ring gland of Drosophila melanogaster. Richard DS, et al. Experientia, 1991 Oct 15. PMID 1936204

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables epoxide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ether hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables juvenile hormone epoxide hydrolase activity IDA
Inferred from Direct Assay
more info
  
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine hydrolase activity HDA PubMed 
Process Evidence Code Pubs
involved_in epoxide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in juvenile hormone catabolic process IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
juvenile hormone epoxide hydrolase 1
Names
CG15101-PA
JH-epoxide hydrolase
Jheh1-PA
juvenile hormone epoxide hydrolase
microsomal apoxide hydrolase
NP_611385.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18853434..18855087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137541.4 → NP_611385.1  juvenile hormone epoxide hydrolase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611385.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8AXY2, Q7JRC3
    Related
    FBpp0085807
    Conserved Domains (3) summary
    COG0596
    Location:159 → 465
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam06441
    Location:64 → 168
    EHN; Epoxide hydrolase N terminus
    pfam12695
    Location:159 → 255
    Abhydrolase_5; Alpha/beta hydrolase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JRC3 Q7JRC3
Q95U55 Q95U55

Gene LinkOut

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