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Bsg basigin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25246, updated on 2-Nov-2024

Summary

Official Symbol
Bsgprovided by RGD
Official Full Name
basiginprovided by RGD
Primary source
RGD:2220
See related
EnsemblRapid:ENSRNOG00000008414 AllianceGenome:RGD:2220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CE9; HT7; 5A11; Ox47R; EMMPRIN; basignin
Summary
Predicted to enable signaling receptor activity and virus receptor activity. Involved in several processes, including decidualization; embryo implantation; and response to cAMP. Located in sarcolemma. Orthologous to human BSG (basigin (Ok blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 2913.9), Heart (RPKM 2509.0) and 9 other tissues See more
Orthologs
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Genomic context

See Bsg in Genome Data Viewer
Location:
7q11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10643788..10651005, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9993170..10000387, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12875536..12882753, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase mitochondrial Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Neighboring gene uncharacterized LOC134479816 Neighboring gene granzyme M Neighboring gene cell division cycle 34, ubiqiutin conjugating enzyme

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-mannose binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in decidualization IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in embryo implantation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial tube morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neural retina development ISO
Inferred from Sequence Orthology
more info
 
involved_in neural retina development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in odontogenesis of dentin-containing tooth IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in photoreceptor cell maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in photoreceptor cell maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of matrix metallopeptidase secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mercury ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in acrosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor inner segment ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor outer segment ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
basigin
Names
Basigin (Ox47 antigen or CE-9) (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian)
Basignin (Ox47 antigen or CE-9) (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian)
OX-47 antigen
basigin (Ok blood group)
glycoprotein CE9
neurothelin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109882.1NP_001103352.1  basigin isoform 1 precursor

    See identical proteins and their annotated locations for NP_001103352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY120888, BQ199464, CV119278
    UniProtKB/Swiss-Prot
    P26453, Q7TNP1
    UniProtKB/TrEMBL
    A0A8I5ZLB7, A6K8Y4
    Related
    ENSRNOP00000011275.5, ENSRNOT00000011275.10
    Conserved Domains (3) summary
    cd00096
    Location:40111
    Ig; Immunoglobulin domain
    smart00410
    Location:228321
    IG_like; Immunoglobulin like
    cl11960
    Location:139203
    Ig; Immunoglobulin domain
  2. NM_012783.3NP_036915.1  basigin isoform 2 precursor

    See identical proteins and their annotated locations for NP_036915.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.
    Source sequence(s)
    BC059145, BQ199464, CV119278
    UniProtKB/TrEMBL
    Q6GT74
    Related
    ENSRNOP00000050252.3, ENSRNOT00000044275.5
    Conserved Domains (3) summary
    cd00096
    Location:122202
    Ig; Immunoglobulin domain
    smart00410
    Location:112205
    IG_like; Immunoglobulin like
    cl11960
    Location:2787
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10643788..10651005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)