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Coq7 coenzyme Q7, hydroxylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25249, updated on 14-Nov-2024

Summary

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Official Symbol
Coq7provided by RGD
Official Full Name
coenzyme Q7, hydroxylaseprovided by RGD
Primary source
RGD:2381
See related
EnsemblRapid:ENSRNOG00000017012 AllianceGenome:RGD:2381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 3-demethoxyubiquinol 3-hydroxylase activity and chromatin binding activity. Involved in response to xenobiotic stimulus and ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrial inner membrane and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 9 and primary coenzyme Q10 deficiency 8. Orthologous to human COQ7 (coenzyme Q7, hydroxylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 253.4), Muscle (RPKM 136.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Coq7 in Genome Data Viewer
Location:
1q35
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (182270570..182285959, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (172836359..172851173, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (188176060..188190874, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485171 Neighboring gene ITPRIP like 2 Neighboring gene uncharacterized LOC120099916 Neighboring gene ubiquitin-like protein FUBI-like Neighboring gene transmembrane channel-like 7 Neighboring gene uncharacterized LOC120099917 Neighboring gene transmembrane channel-like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning, expression, and homology modeling of GroEL protein from Leptospira interrogans serovar autumnalis strain N2. Natarajaseenivasan K, et al. Genomics Proteomics Bioinformatics, 2011 Oct. PMID 22196358, Free PMC Article
  2. Lifelong protection from global cerebral ischemia and reperfusion in long-lived Mclk1(+/)(-) mutants. Zheng H, et al. Exp Neurol, 2010 Jun. PMID 20170652, Free PMC Article
  3. Early mitochondrial dysfunction in long-lived Mclk1+/- mice. Lapointe J, et al. J Biol Chem, 2008 Sep 19. PMID 18635541, Free PMC Article
  4. Proteomic analysis of early left ventricular hypertrophy secondary to hypertension: modulation by antihypertensive therapies. Gallego-Delgado J, et al. J Am Soc Nephrol, 2006 Dec. PMID 17130255
  5. Fenofibrate activates the biochemical pathways and the de novo expression of genes related to lipid handling and uncoupling protein-3 functions in liver of normal rats. Silvestri E, et al. Biochim Biophys Acta, 2006 May-Jun. PMID 16595124

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. groEL gene encodes a protein of 60 kDa with a high degree of homology (99% similarity) to those of other leptospiral serovar
    Title: Cloning, expression, and homology modeling of GroEL protein from Leptospira interrogans serovar autumnalis strain N2.
  2. In proteomic study of left ventricular hypertrophy, three altered protein spots corresponded to two unique proteins that were identified as Calsarcin-1 (CS-1) and ubiquinone biosynthesis protein COQ7 homolog.
    Title: Proteomic analysis of early left ventricular hypertrophy secondary to hypertension: modulation by antihypertensive therapies.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-demethoxyubiquinol 3-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-demethoxyubiquinol 3-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in determination of adult lifespan IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrial ATP synthesis coupled electron transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of reactive oxygen species metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within respiratory electron transport chain ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT acts_upstream_of_or_within ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquinone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extrinsic component of mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquinone biosynthesis complex IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquinone biosynthesis complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
5-demethoxyubiquinone hydroxylase, mitochondrial
Names
Coenzyme q (ubiquinone) biosynthetic enzyme (DHPB methyltransferase) 7
DMQ hydroxylase
coenzyme Q biosynthesis protein 7 homolog
coenzyme Q7 homolog, ubiquinone
demethyl-Q 7
timing protein clk-1 homolog
ubiquinone biosynthesis monooxygenase COQ7
ubiquinone biosynthesis protein COQ7 homolog
NP_036917.2
XP_006230170.1
XP_038957455.1
XP_063137596.1
XP_063137598.1
XP_063137603.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012785.3 → NP_036917.2  5-demethoxyubiquinone hydroxylase, mitochondrial

    See identical proteins and their annotated locations for NP_036917.2

    Status: VALIDATED

    Source sequence(s)
    AI711299, BF558335, FQ225865
    UniProtKB/Swiss-Prot
    O08887, Q63619
    UniProtKB/TrEMBL
    A6I8H3, G3V879
    Conserved Domains (1) summary
    pfam03232
    Location:49 → 216
    COQ7; Ubiquinone biosynthesis protein COQ7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    182270570..182285959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281528.1 → XP_063137598.1  5-demethoxyubiquinone hydroxylase, mitochondrial isoform X2

  2. XM_063281526.1 → XP_063137596.1  5-demethoxyubiquinone hydroxylase, mitochondrial isoform X1

  3. XM_006230108.4 → XP_006230170.1  5-demethoxyubiquinone hydroxylase, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_006230170.1

    UniProtKB/TrEMBL
    A6I8H4
    Related
    ENSRNOP00000022988.7, ENSRNOT00000022988.7
    Conserved Domains (1) summary
    pfam03232
    Location:69 → 236
    COQ7; Ubiquinone biosynthesis protein COQ7

  4. XM_063281533.1 → XP_063137603.1  5-demethoxyubiquinone hydroxylase, mitochondrial isoform X4

  5. XM_039101527.2 → XP_038957455.1  5-demethoxyubiquinone hydroxylase, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl00264
    Location:69 → 104
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63619.3 GenPept UniProtKB/Swiss-Prot:Q63619

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