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Cox8b cytochrome c oxidase, subunit VIIIb [ Rattus norvegicus (Norway rat) ]

Gene ID: 25250, updated on 29-Feb-2024

Summary

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Official Symbol
Cox8bprovided by RGD
Official Full Name
cytochrome c oxidase, subunit VIIIbprovided by RGD
Primary source
RGD:2386
See related
AllianceGenome:RGD:2386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CCO8A; Cox8h; COXVIII-H
Summary
Predicted to enable cytochrome-c oxidase activity. Involved in response to xenobiotic stimulus. Predicted to be integral component of membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrion. Used to study obesity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 12462.9), Muscle (RPKM 9124.6) and 1 other tissue See more
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Genomic context

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See Cox8b in Genome Data Viewer
Location:
1q41
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205406813..205408273, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (195977183..195978643, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (213648787..213650247, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sirtuin 3 Neighboring gene proteasome 26S subunit, non-ATPase 13 Neighboring gene NLR family, pyrin domain containing 6 Neighboring gene protein-glucosylgalactosylhydroxylysine glucosidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DNA microarray analysis of white adipose tissue from obese (fa/fa) Zucker rats treated with a beta3-adrenoceptor agonist, KTO-7924. Oana F, et al. Pharmacol Res, 2005 Nov. PMID 16027000
  2. The role of an E box binding basic helix loop helix protein in the cardiac muscle-specific expression of the rat cytochrome oxidase subunit VIII gene. Lenka N, et al. J Biol Chem, 1996 Nov 22. PMID 8939982
  3. Nucleotide sequence of cDNA encoding subunit VIII of cytochrome c oxidase from rat heart. Scheja K, et al. Biochim Biophys Acta, 1992 Aug 17. PMID 1324738
  4. Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. Li P, et al. Cell Mol Life Sci, 2003 Oct. PMID 14618266, Free PMC Article
  5. Tissue- and species-specific expression of cytochrome c oxidase isozymes in vertebrates. Kadenbach B, et al. Biochim Biophys Acta, 1990 Feb 2. PMID 2153407

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytochrome-c oxidase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen TAS
Traceable Author Statement
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of mitochondrial respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 8B, mitochondrial
Names
Cytochrom c oxidase subunit VIII-H (heart/muscle)
Cytochrome c oxidase subunit VIII-H (heart/muscle)
cytochrome c oxidase polypeptide VIII-heart
cytochrome c oxidase subunit 8-1
cytochrome c oxidase subunit 8H
cytochrome c oxidase, subunit 8B
cytochrome c oxidase, subunit VIIIb, muscle
NP_036918.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012786.3 → NP_036918.2  cytochrome c oxidase subunit 8B, mitochondrial precursor

    See identical proteins and their annotated locations for NP_036918.2

    Status: VALIDATED

    Source sequence(s)
    FM054348, X64827
    UniProtKB/Swiss-Prot
    P16221
    UniProtKB/TrEMBL
    A6HXL6
    Conserved Domains (1) summary
    pfam02285
    Location:26 → 66
    COX8; Cytochrome oxidase c subunit VIII

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    205406813..205408273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16221.3 GenPept UniProtKB/Swiss-Prot:P16221

Gene LinkOut

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