Dpp4 dipeptidylpeptidase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dpp4provided by RGD
Official Full Name: dipeptidylpeptidase 4provided by RGD
Primary source: RGD:2515
See related: EnsemblRapid:ENSRNOG00000030763 AllianceGenome:RGD:2515
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CD26; DPPIV
Summary: Enables several functions, including collagen binding activity; dipeptidyl-peptidase activity; and identical protein binding activity. Involved in several processes, including B-1a B cell differentiation; proteolysis; and regulation of lymphocyte mediated immunity. Located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 1492.6), Liver (RPKM 372.0) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (67370794..67452422, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (46962233..47043870, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (48291055..48372672, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate Senescent Cells via DPP4 Targeting and PARP1 Activation.
Title: Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate Senescent Cells via DPP4 Targeting and PARP1 Activation.
Knockdown of DPP4 promotes the proliferation and the activation of the CREB/aromatase pathway in ovarian granulosa cells.
Title: Knockdown of DPP4 promotes the proliferation and the activation of the CREB/aromatase pathway in ovarian granulosa cells.
Inhibition of dipeptidyl peptidase-4 averts free fatty acids deposition in the hearts of oral estrogen-progestin contraceptive-induced hyperinsulinemic female rats.
Title: Inhibition of dipeptidyl peptidase-4 averts free fatty acids deposition in the hearts of oral estrogen-progestin contraceptive-induced hyperinsulinemic female rats.
Dipeptidyl Peptidase-4 deficiency effectively protects the brain and neurological function in rodent after acute Hemorrhagic Stroke.
Title: Dipeptidyl Peptidase-4 deficiency effectively protects the brain and neurological function in rodent after acute Hemorrhagic Stroke.
miR-448-3p alleviates diabetic vascular dysfunction by inhibiting endothelial-mesenchymal transition through DPP-4 dysregulation.
Title: miR-448-3p alleviates diabetic vascular dysfunction by inhibiting endothelial-mesenchymal transition through DPP-4 dysregulation.
Less pulmonary inflammation combined with less structural alterations and minor expression of immunomodulating surfactant proteins may be an indication of the critical role of CD26/DPP4 in regulating lung inflammation
Title: Differential severity of LPS-induced lung injury in CD26/DPP4 positive and deficient F344 rats.
CD26/DPP4 deficiency resulted in reduced pulmonary edema under sublethal Pseudomonas aeruginosa infection, implicating a role for CD26 in infection progression. The partly pronounced structural damage may mask further possible influences of CD26 on the inflammatory response.
Title: Lung infection caused by Pseudomonas aeruginosa in a CD26/DPP4 deficient F344 rat model.
Our results suggest pathology and glia-type specific changes of DPP4 activity in the spinal cord, which contribute to the development and maintenance of hyperalgesia and interact with endogenous opioid systems.
Title: Glial cell type-specific changes in spinal dipeptidyl peptidase 4 expression and effects of its inhibitors in inflammatory and neuropatic pain.
Study demonstrates that gestational glucocorticoid (GC) exposure during late pregnancy induced impaired glucose homeostasis that is accompanied by increased endoglin levels, atherogenic dyslipidemia and pancreatic beta cell dysfunction, increased DPP-4 activity and altered foetal outcome. Therefore, GC-induced glucose deregulation and inflammation during late gestation is through endoglin-/DPP-4-dependent pathway.
Title: Gestational glucocorticoid exposure disrupts glucose homeostasis that is accompanied by increased endoglin and DPP-4 activity instead of GSK-3 in rats.
Proteome profile array screening further revealed that DPPIV decreases matrix metalloproteinase-9, a key downstream effector of ERK-AKT signaling pathways
Title: Regulation of Dipeptidyl Peptidase IV in the Post-stroke Rat Brain and In Vitro Ischemia: Implications for Chemokine-Mediated Neural Progenitor Cell Migration and Angiogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (67)

General gene information

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Markers

DPP4 (e-PCR)
- UniSTS:505438

GDB:207675 (e-PCR)
- UniSTS:156121

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables chemorepellent activity	ISO Inferred from Sequence Orthology more info
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables dipeptidyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptidyl-peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables dipeptidyl-peptidase activity	IEA Inferred from Electronic Annotation more info
enables dipeptidyl-peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables dipeptidyl-peptidase activity	ISO Inferred from Sequence Orthology more info
enables dipeptidyl-peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B-1a B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in T cell costimulation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within locomotory exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extracellular matrix disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of natural killer cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within psychomotor behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in intercellular canaliculus	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dipeptidyl peptidase 4

Names: DPP IV; GP110 glycoprotein; T-cell activation antigen CD26; bile canaliculus domain-specific membrane glycoprotein; dipeptidyl peptidase IV

NP_036921.2

EC 3.4.14.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012789.2 → NP_036921.2 dipeptidyl peptidase 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P14740

UniProtKB/TrEMBL

A6HLV5

Related

ENSRNOP00000068881.2, ENSRNOT00000085426.3

Conserved Domains (3) summary

pfam00326
Location:560 → 764

Peptidase_S9; Prolyl oligopeptidase family

pfam00930
Location:106 → 479

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

pfam18811
Location:36 → 56

DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region