Gp5 glycoprotein V (platelet) [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Gp5provided by RGD
Full Name: glycoprotein V (platelet)provided by RGD
Primary source: RGD:2724
See related: EnsemblRapid:ENSRNOG00000038540 AllianceGenome:RGD:2724
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PLGPV
Summary: Predicted to enable collagen binding activity. Predicted to be involved in blood coagulation. Predicted to act upstream of or within cell-matrix adhesion and negative regulation of platelet activation. Located in cell surface. Orthologous to human GP5 (glycoprotein V platelet). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 41.8), Brain (RPKM 10.1) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (83948507..83952362)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (70443613..70446705)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (73015380..73017570)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation, intrinsic pathway	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation, intrinsic pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in megakaryocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of platelet activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
part_of glycoprotein Ib-IX-V complex	IEA Inferred from Electronic Annotation more info
part_of glycoprotein Ib-IX-V complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet glycoprotein V

Names: GPV; Platelet glycoprotein 5; Platelete glycoprotein 5; glycoprotein 5, platelet

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012795.3 → NP_036927.2 platelet glycoprotein V precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

O08770

UniProtKB/TrEMBL

A6JRV1, G3V9H9

Related

ENSRNOP00000047810.2, ENSRNOT00000040884.4

Conserved Domains (4) summary

PRK15370
Location:103 → 422

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:394 → 458

PCC; polycystin cation channel protein

sd00033
Location:100 → 123

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:64 → 110

LRR_8; Leucine rich repeat