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FUT4 fucosyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 2526, updated on 5-Mar-2024

Summary

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Official Symbol
FUT4provided by HGNC
Official Full Name
fucosyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:4015
See related
Ensembl:ENSG00000196371 MIM:104230; AllianceGenome:HGNC:4015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV
Summary
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]
Orthologs
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Genomic context

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See FUT4 in Genome Data Viewer
Location:
11q21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (94543921..94549895)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (94550967..94556942)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94277087..94283061)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MRE11 homolog, double strand break repair nuclease Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5403 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:94245285-94245803 Neighboring gene ankyrin repeat domain 49 Neighboring gene chromosome 11 open reading frame 97 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3843 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:94278664-94279338 Neighboring gene PIWIL4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:94300071-94300572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:94300573-94301072 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:94317056-94318255 Neighboring gene piwi like RNA-mediated gene silencing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5405 Neighboring gene MPRA-validated peak1402 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:94373181-94373680 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:94379786-94380519 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:94382939-94383514 Neighboring gene long intergenic non-protein coding RNA 2700 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:94389595-94390531

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CD15 immunostaining improves placental diagnosis of fetal hypoxia. Seidmann L, et al. Placenta, 2021 Feb. PMID 33545630
  2. Specific Norovirus Interaction with Lewis x and Lewis a on Human Intestinal Inflammatory Mucosa during Refractory Inflammatory Bowel Disease. Tarris G, et al. mSphere, 2021 Jan 13. PMID 33441404, Free PMC Article
  3. Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma. Lu HH, et al. EBioMedicine, 2020 Jul. PMID 32629386, Free PMC Article
  4. Expression of the cancer stem cell marker SSEA1 is associated with poor survival in metastatic high-grade serous carcinoma. Davidson B, et al. Virchows Arch, 2020 Nov. PMID 32472195, Free PMC Article
  5. Role of fucosyltransferase IV in the migration and invasion of human melanoma cells. Shan X, et al. IUBMB Life, 2020 May. PMID 31961483

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells and associates with cancer cell motility.
    Title: ST3GalIV drives SLeX biosynthesis in gastrointestinal cancer cells and associates with cancer cell motility.
  2. X-ray inhibits FUT4-mediated proliferation in A549 cells by downregulating SP1 expression.
    Title: X-ray inhibits FUT4-mediated proliferation in A549 cells by downregulating SP1 expression.
  3. SMYD2 facilitates cancer cell malignancy and xenograft tumor development through ERBB2-mediated FUT4 expression in colon cancer.
    Title: SMYD2 facilitates cancer cell malignancy and xenograft tumor development through ERBB2-mediated FUT4 expression in colon cancer.
  4. CD15(+) Bone Marrow-derived Cells Are Regulators of Immune Response in ARG1-producing Colorectal Cancer Cells.
    Title: CD15(+) Bone Marrow-derived Cells Are Regulators of Immune Response in ARG1-producing Colorectal Cancer Cells.
  5. CD15 immunostaining improves placental diagnosis of fetal hypoxia.
    Title: CD15 immunostaining improves placental diagnosis of fetal hypoxia.
  6. MyoD1 suppresses cell migration and invasion by inhibiting FUT4 transcription in human gastric cancer cells.
    Title: MyoD1 suppresses cell migration and invasion by inhibiting FUT4 transcription in human gastric cancer cells.
  7. Specific Norovirus Interaction with Lewis x and Lewis a on Human Intestinal Inflammatory Mucosa during Refractory Inflammatory Bowel Disease.
    Title: Specific Norovirus Interaction with Lewis x and Lewis a on Human Intestinal Inflammatory Mucosa during Refractory Inflammatory Bowel Disease.
  8. Role of fucosyltransferase IV in the migration and invasion of human melanoma cells.
    Title: Role of fucosyltransferase IV in the migration and invasion of human melanoma cells.
  9. Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma.
    Title: Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma.
  10. Long noncoding RNA GAS6-AS2 sponges microRNA-493, thereby enhancing the malignant characteristics of breast cancer cells via upregulation of FUT4.
    Title: Long noncoding RNA GAS6-AS2 sponges microRNA-493, thereby enhancing the malignant characteristics of breast cancer cells via upregulation of FUT4.
Submit: New GeneRIF Correction See all GeneRIFs (85)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables alpha-(1->3)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-(1->3)-fucosyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables fucosyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-fucose catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in lymphocyte migration into lymph node ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oligosaccharide biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in oligosaccharide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of leukocyte tethering or rolling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neutrophil migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
 PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha-(1,3)-fucosyltransferase 4
Names
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
ELAM ligand fucosyltransferase
ELAM-1 ligand fucosyltransferase
Lewis X
alpha (1,3) fucosyltransferase, myeloid-specific
fucT-IV
fucosyltransferase IV
galactoside 3-L-fucosyltransferase
stage-specific embryonic antigen 1
NP_002024.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002033.4 → NP_002024.1  alpha-(1,3)-fucosyltransferase 4

    See identical proteins and their annotated locations for NP_002024.1

    Status: REVIEWED

    Source sequence(s)
    AP000943
    Consensus CDS
    CCDS8301.1
    UniProtKB/Swiss-Prot
    B2RMS0, P22083
    Related
    ENSP00000351602.2, ENST00000358752.4
    Conserved Domains (2) summary
    pfam00852
    Location:353 → 525
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:186 → 331
    Glyco_tran_10_N; Fucosyltransferase, N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    94543921..94549895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    94550967..94556942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22083.3 GenPept UniProtKB/Swiss-Prot:P22083

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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