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Proc protein C, inactivator of coagulation factors Va and VIIIa [ Rattus norvegicus (Norway rat) ]

Gene ID: 25268, updated on 2-Nov-2024

Summary

Official Symbol
Procprovided by RGD
Official Full Name
protein C, inactivator of coagulation factors Va and VIIIaprovided by RGD
Primary source
RGD:3411
See related
EnsemblRapid:ENSRNOG00000014376 AllianceGenome:RGD:3411
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables identical protein binding activity and oligopeptidase activity. Involved in liver development; negative regulation of blood coagulation; and protein catabolic process. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; central retinal vein occlusion; placental abruption; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human PROC (protein C, inactivator of coagulation factors Va and VIIIa). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 1373.6) See more
Orthologs
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Genomic context

See Proc in Genome Data Viewer
Location:
18p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (24038596..24049061, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23764367..23774816, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24918402..24928822, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482980 Neighboring gene POTE ankyrin domain family, member F Neighboring gene interacts with SUPT6H, CTD assembly factor 1 Neighboring gene uncharacterized LOC134482924 Neighboring gene mitogen activated protein kinase kinase kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oligopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in liver development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of coagulation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of coagulation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of establishment of endothelial barrier IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of establishment of endothelial barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of circulating fibrinogen levels ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
vitamin K-dependent protein C
Names
anticoagulant protein C
autoprothrombin IIA
blood coagulation factor XIV
NP_036935.1
XP_006254589.1
XP_008770240.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012803.1NP_036935.1  vitamin K-dependent protein C precursor

    See identical proteins and their annotated locations for NP_036935.1

    Status: PROVISIONAL

    Source sequence(s)
    X64336
    UniProtKB/Swiss-Prot
    P31394
    UniProtKB/TrEMBL
    A6J2Q1
    Related
    ENSRNOP00000100621.1, ENSRNOT00000124587.1
    Conserved Domains (5) summary
    smart00020
    Location:212445
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:2686
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:87131
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:213447
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:139174
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    24038596..24049061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254527.4XP_006254589.1  vitamin K-dependent protein C isoform X2

    See identical proteins and their annotated locations for XP_006254589.1

    UniProtKB/TrEMBL
    A6J2Q1, Q68FY8
    Related
    ENSRNOP00000019596.5, ENSRNOT00000019596.6
    Conserved Domains (4) summary
    smart00069
    Location:2686
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:87131
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:213447
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:139174
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. XM_008772018.4XP_008770240.3  vitamin K-dependent protein C isoform X1

    UniProtKB/TrEMBL
    A6J2Q1, F7FMY6
    Conserved Domains (4) summary
    smart00069
    Location:65125
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:126170
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:252486
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:178213
    FXa_inhibition; Coagulation Factor Xa inhibitory site