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Stx17 syntaxin 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 252853, updated on 2-Nov-2024

Summary

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Official Symbol
Stx17provided by RGD
Official Full Name
syntaxin 17provided by RGD
Primary source
RGD:708499
See related
EnsemblRapid:ENSRNOG00000005801 AllianceGenome:RGD:708499
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables SNARE binding activity and protein kinase binding activity. Predicted to be involved in several processes, including autophagosome membrane docking; endoplasmic reticulum to Golgi vesicle-mediated transport; and endoplasmic reticulum-Golgi intermediate compartment organization. Predicted to act upstream of or within protein localization to phagophore assembly site. Located in several cellular components, including COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum-Golgi intermediate compartment; and smooth endoplasmic reticulum membrane. Orthologous to human STX17 (syntaxin 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 101.0), Liver (RPKM 52.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stx17 in Genome Data Viewer
Location:
5q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (67241673..67302228)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (62446138..62506108)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (63866346..63926276)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102873 Neighboring gene uncharacterized LOC120102874 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134478966 Neighboring gene nuclear receptor subfamily 4, group A, member 3 Neighboring gene exosome component 8, pseudogene 1 Neighboring gene endoplasmic reticulum protein 44 Neighboring gene inversin Neighboring gene uncharacterized LOC102551711

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hyperoxia reduces STX17 expression and inhibits the autophagic flux in alveolar type II epithelial cells in newborn rats. Zhang D, et al. Int J Mol Med, 2020 Aug. PMID 32467992, Free PMC Article
  2. Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics. Steegmaier M, et al. Mol Biol Cell, 2000 Aug. PMID 10930465, Free PMC Article
  3. Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17. Cheng X, et al. Mol Cell, 2017 Mar 16. PMID 28306502
  4. Tyrosine phosphorylation of a SNARE protein, syntaxin 17: implications for membrane trafficking in the early secretory pathway. Muppirala M, et al. Biochim Biophys Acta, 2012 Dec. PMID 23006999
  5. Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi. Muppirala M, et al. Biol Cell, 2011 Jul. PMID 21545355

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hyperoxia reduces STX17 expression and inhibits the autophagic flux in alveolar type II epithelial cells in newborn rats.
    Title: Hyperoxia reduces STX17 expression and inhibits the autophagic flux in alveolar type II epithelial cells in newborn rats.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables SNAP receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in autophagosome membrane docking ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endoplasmic reticulum-Golgi intermediate compartment organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum-Golgi intermediate compartment organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to phagophore assembly site ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
part_of HOPS complex ISO
Inferred from Sequence Orthology
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
part_of SNARE complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
NOT located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
Inferred from Sequence Orthology
more info
  
NOT located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in smooth endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
syntaxin-17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145723.2 → NP_663775.1  syntaxin-17

    See identical proteins and their annotated locations for NP_663775.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q9Z158
    UniProtKB/TrEMBL
    A6KJF9
    Related
    ENSRNOP00000007641.2, ENSRNOT00000007641.6
    Conserved Domains (1) summary
    cd15846
    Location:161 → 222
    SNARE_syntaxin17; SNARE motif of syntaxin 17

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    67241673..67302228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109285.2 → XP_038965213.1  syntaxin-17 isoform X2

    Conserved Domains (1) summary
    cl22856
    Location:161 → 201
    SNARE; SNARE motif

  2. XM_039109286.2 → XP_038965214.1  syntaxin-17 isoform X4

    Conserved Domains (1) summary
    cl22856
    Location:161 → 194
    SNARE; SNARE motif

  3. XM_063287172.1 → XP_063143242.1  syntaxin-17 isoform X3

  4. XM_063287173.1 → XP_063143243.1  syntaxin-17 isoform X5

  5. XM_063287174.1 → XP_063143244.1  syntaxin-17 isoform X5

  6. XM_006238024.4 → XP_006238086.1  syntaxin-17 isoform X1

    See identical proteins and their annotated locations for XP_006238086.1

    UniProtKB/Swiss-Prot
    Q9Z158
    UniProtKB/TrEMBL
    A6KJF9
    Conserved Domains (1) summary
    cd15846
    Location:161 → 222
    SNARE_syntaxin17; SNARE motif of syntaxin 17

  7. XM_017593152.3 → XP_017448641.1  syntaxin-17 isoform X1

    UniProtKB/Swiss-Prot
    Q9Z158
    UniProtKB/TrEMBL
    A6KJF9
    Conserved Domains (1) summary
    cd15846
    Location:161 → 222
    SNARE_syntaxin17; SNARE motif of syntaxin 17

RNA

  1. XR_005504369.2 RNA Sequence

  2. XR_005504370.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z158.1 GenPept UniProtKB/Swiss-Prot:Q9Z158

Gene LinkOut

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