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Usp7 ubiquitin specific peptidase 7 [ Mus musculus (house mouse) ]

Gene ID: 252870, updated on 2-Nov-2024

Summary

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Official Symbol
Usp7provided by MGI
Official Full Name
ubiquitin specific peptidase 7provided by MGI
Primary source
MGI:MGI:2182061
See related
Ensembl:ENSMUSG00000022710 AllianceGenome:MGI:2182061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hausp; 2210010O09Rik
Summary
Enables cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Involved in several processes, including protein deubiquitination; regulation of protein stability; and transcription elongation-coupled chromatin remodeling. Located in XY body; cytoplasm; and nucleus. Is expressed in blastocyst; embryo; inner cell mass; and trophectoderm. Orthologous to human USP7 (ubiquitin specific peptidase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.2), liver E14 (RPKM 24.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Usp7 in Genome Data Viewer
Location:
16 A1; 16 4.28 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (8506586..8574931, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (8688722..8757067, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 186 Neighboring gene phosphomannomutase 2 Neighboring gene calcium regulated heat stable protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8616 Neighboring gene LITAF domain containing Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:8745912-8746157 Neighboring gene STARR-seq mESC enhancer starr_40018 Neighboring gene STARR-seq mESC enhancer starr_40019 Neighboring gene STARR-positive B cell enhancer ABC_E8906 Neighboring gene STARR-seq mESC enhancer starr_40021 Neighboring gene predicted gene, 25805 Neighboring gene STARR-seq mESC enhancer starr_40028 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:8829797-8829906 Neighboring gene STARR-seq mESC enhancer starr_40031 Neighboring gene HUWE1 associated protein modifying stress responses Neighboring gene predicted gene, 52232

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. USP7 Attenuates Endoplasmic Reticulum Stress and NF-κB Signaling to Modulate Chondrocyte Proliferation, Apoptosis, and Inflammatory Response under Inflammation. Dong X, et al. Oxid Med Cell Longev, 2022. PMID 35432716, Free PMC Article
  2. Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice. Qiao H, et al. iScience, 2022 Jul 15. PMID 35800757, Free PMC Article
  3. USP7 cardiomyocyte specific knockout causes disordered mitochondrial biogenesis and dynamics and early neonatal lethality in mice. Yan M, et al. Int J Cardiol, 2024 Aug 1. PMID 38723908
  4. Organ defects of the Usp7(K444R) mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation. Wu HT, et al. Biomed J, 2023 Feb. PMID 35183794, Free PMC Article
  5. Ubiquitin-specific protease 7 is a druggable target that is essential for pancreatic cancer growth and chemoresistance. Chen H, et al. Invest New Drugs, 2020 Dec. PMID 32468271

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation.
    Title: USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation.
  2. USP7 Promotes TGF-beta1 Signaling by De-Ubiquitinating Smad2/Smad3 in Pulmonary Fibrosis.
    Title: USP7 Promotes TGF-β1 Signaling by De-Ubiquitinating Smad2/Smad3 in Pulmonary Fibrosis.
  3. USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1beta.
    Title: USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1β.
  4. USP7 cardiomyocyte specific knockout causes disordered mitochondrial biogenesis and dynamics and early neonatal lethality in mice.
    Title: USP7 cardiomyocyte specific knockout causes disordered mitochondrial biogenesis and dynamics and early neonatal lethality in mice.
  5. DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1alpha.
    Title: DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1α.
  6. Extracellular vesicles from bone marrow mesenchymal stem cells alleviate osteoporosis in mice through USP7-mediated YAP1 protein stability and the Wnt/beta-catenin pathway.
    Title: Extracellular vesicles from bone marrow mesenchymal stem cells alleviate osteoporosis in mice through USP7-mediated YAP1 protein stability and the Wnt/β-catenin pathway.
  7. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.
    Title: USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.
  8. USP7 reduction leads to developmental failure of mouse early embryos.
    Title: USP7 reduction leads to developmental failure of mouse early embryos.
  9. USP7 controls NGN3 stability and pancreatic endocrine lineage development.
    Title: USP7 controls NGN3 stability and pancreatic endocrine lineage development.
  10. Organ defects of the Usp7[K444R] mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation.
    Title: Organ defects of the Usp7(K444R) mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables K48-linked deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA alkylation repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA alkylation repair ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within monoubiquitinated protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression via chromosomal CpG island methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
involved_in symbiont-mediated disruption of host cell PML body ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription elongation-coupled chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription-coupled nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription-coupled nucleotide-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
is_active_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in XY body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 7
Names
deubiquitinating enzyme 7
herpesvirus-associated ubiquitin-specific protease
mHAUSP
ubiquitin specific protease 7
ubiquitin thioesterase 7
ubiquitin thiolesterase 7
ubiquitin-specific-processing protease 7
NP_001003918.2
XP_006522201.1
XP_006522202.1
XP_006522204.1
XP_030104976.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003918.2 → NP_001003918.2  ubiquitin carboxyl-terminal hydrolase 7

    See identical proteins and their annotated locations for NP_001003918.2

    Status: VALIDATED

    Source sequence(s)
    AC115005, AC156026, AF548565, AK135814
    Consensus CDS
    CCDS49755.1
    UniProtKB/Swiss-Prot
    Q3UX92, Q496Y5, Q6A4J8, Q8BW01
    UniProtKB/TrEMBL
    F8VPX1
    Related
    ENSMUSP00000124093.3, ENSMUST00000161046.9
    Conserved Domains (5) summary
    COG5077
    Location:56 → 1101
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02659
    Location:213 → 524
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd03772
    Location:68 → 203
    MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
    pfam12436
    Location:621 → 866
    USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
    pfam14533
    Location:876 → 1087
    USP7_C2; Ubiquitin-specific protease C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    8506586..8574931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522138.4 → XP_006522201.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X1

    UniProtKB/Swiss-Prot
    Q3UX92, Q496Y5, Q6A4J8, Q8BW01
    UniProtKB/TrEMBL
    E9PXY8
    Related
    ENSMUSP00000124382.2, ENSMUST00000160405.8
    Conserved Domains (1) summary
    COG5077
    Location:96 → 1141
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

  2. XM_006522141.4 → XP_006522204.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X3

    UniProtKB/Swiss-Prot
    Q3UX92, Q496Y5, Q6A4J8, Q8BW01
    Conserved Domains (1) summary
    COG5077
    Location:6 → 1001
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

  3. XM_030249116.2 → XP_030104976.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X3

    UniProtKB/Swiss-Prot
    Q3UX92, Q496Y5, Q6A4J8, Q8BW01
    Conserved Domains (1) summary
    COG5077
    Location:6 → 1001
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

  4. XM_006522139.4 → XP_006522202.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X2

    UniProtKB/Swiss-Prot
    Q3UX92, Q496Y5, Q6A4J8, Q8BW01
    Conserved Domains (1) summary
    COG5077
    Location:39 → 1084
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6A4J8.1 GenPept UniProtKB/Swiss-Prot:Q6A4J8

Gene LinkOut

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