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ZNF396 zinc finger protein 396 [ Homo sapiens (human) ]

Gene ID: 252884, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF396provided by HGNC
Official Full Name
zinc finger protein 396provided by HGNC
Primary source
HGNC:HGNC:18824
See related
Ensembl:ENSG00000186496 MIM:609600; AllianceGenome:HGNC:18824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSCAN14
Summary
Enables protein heterodimerization activity; protein homodimerization activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of DNA-templated transcription. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thyroid (RPKM 1.8), testis (RPKM 1.3) and 24 other tissues See more
Orthologs
all
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Genomic context

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See ZNF396 in Genome Data Viewer
Location:
18q12.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (35366694..35377337, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (35558034..35568691, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (32946658..32957301, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13222 Neighboring gene zinc finger protein 271, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32904859-32905554 Neighboring gene zinc finger protein 24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13223 Neighboring gene uncharacterized LOC124904283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9396 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32934967-32935487 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32936140-32936672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9399 Neighboring gene Sharpr-MPRA regulatory region 14792 Neighboring gene ribosomal protein L7a pseudogene 67 Neighboring gene uncharacterized LOC105372063

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of ZNF396 in basal cell carcinoma. Bai J, et al. Arch Dermatol Res, 2014 May. PMID 24445935
  2. Identification and characterization of two novel human SCAN domain-containing zinc finger genes ZNF396 and ZNF397. Wu Y, et al. Gene, 2003 May 22. PMID 12801647
  3. A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation. Poh J, et al. Redox Biol, 2020 Oct. PMID 32911434, Free PMC Article
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. Deng X, et al. PLoS One, 2013. PMID 24324551, Free PMC Article
  5. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31213

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 396
Names
zinc finger and SCAN domain-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322286.2 → NP_001309215.1  zinc finger protein 396 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007998, AF533251
    Consensus CDS
    CCDS82247.1
    UniProtKB/Swiss-Prot
    A1L3V0, Q8NF98, Q8TD80, Q96N95
    Related
    ENSP00000466500.1, ENST00000589332.7
    Conserved Domains (6) summary
    smart00431
    Location:48 → 157
    SCAN; leucine rich region
    COG5048
    Location:239 → 306
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:252 → 273
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:48 → 136
    SCAN; SCAN domain
    pfam13465
    Location:294 → 318
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001322290.2 → NP_001309219.1  zinc finger protein 396 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007998
    Consensus CDS
    CCDS82247.1
    UniProtKB/Swiss-Prot
    A1L3V0, Q8NF98, Q8TD80, Q96N95
    Conserved Domains (6) summary
    smart00431
    Location:48 → 157
    SCAN; leucine rich region
    COG5048
    Location:239 → 306
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:252 → 273
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:48 → 136
    SCAN; SCAN domain
    pfam13465
    Location:294 → 318
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001322291.2 → NP_001309220.1  zinc finger protein 396 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007998, AF492004, BM713411
    Consensus CDS
    CCDS82246.1
    UniProtKB/Swiss-Prot
    Q96N95
    Related
    ENSP00000467275.1, ENST00000586687.5
    Conserved Domains (2) summary
    smart00431
    Location:48 → 157
    SCAN; leucine rich region
    pfam02023
    Location:48 → 136
    SCAN; SCAN domain

  4. NM_145756.3 → NP_665699.1  zinc finger protein 396 isoform 2

    See identical proteins and their annotated locations for NP_665699.1

    Status: VALIDATED

    Source sequence(s)
    AC007998, AK055775
    Consensus CDS
    CCDS11913.1
    UniProtKB/Swiss-Prot
    Q96N95
    Related
    ENSP00000302310.1, ENST00000306346.5
    Conserved Domains (3) summary
    smart00431
    Location:48 → 157
    SCAN; leucine rich region
    COG5048
    Location:239 → 302
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    35366694..35377337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025689.2 → XP_016881178.1  zinc finger protein 396 isoform X2

    Conserved Domains (1) summary
    smart00431
    Location:48 → 157
    SCAN; leucine rich region

  2. XM_006722432.4 → XP_006722495.1  zinc finger protein 396 isoform X1

    See identical proteins and their annotated locations for XP_006722495.1

    UniProtKB/Swiss-Prot
    A1L3V0, Q8NF98, Q8TD80, Q96N95
    Conserved Domains (6) summary
    smart00431
    Location:48 → 157
    SCAN; leucine rich region
    COG5048
    Location:239 → 306
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:252 → 273
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:48 → 136
    SCAN; SCAN domain
    pfam13465
    Location:294 → 318
    zf-H2C2_2; Zinc-finger double domain

  3. XM_024451138.2 → XP_024306906.1  zinc finger protein 396 isoform X2

    Conserved Domains (1) summary
    smart00431
    Location:48 → 157
    SCAN; leucine rich region

  4. XM_017025687.2 → XP_016881176.1  zinc finger protein 396 isoform X1

    UniProtKB/Swiss-Prot
    A1L3V0, Q8NF98, Q8TD80, Q96N95
    Conserved Domains (6) summary
    smart00431
    Location:48 → 157
    SCAN; leucine rich region
    COG5048
    Location:239 → 306
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:252 → 273
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:48 → 136
    SCAN; SCAN domain
    pfam13465
    Location:294 → 318
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    35558034..35568691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318474.1 → XP_054174449.1  zinc finger protein 396 isoform X2

  2. XM_054318472.1 → XP_054174447.1  zinc finger protein 396 isoform X1

    UniProtKB/Swiss-Prot
    A1L3V0, Q8NF98, Q8TD80, Q96N95

  3. XM_054318475.1 → XP_054174450.1  zinc finger protein 396 isoform X2

  4. XM_054318473.1 → XP_054174448.1  zinc finger protein 396 isoform X1

    UniProtKB/Swiss-Prot
    A1L3V0, Q8NF98, Q8TD80, Q96N95
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96N95.2 GenPept UniProtKB/Swiss-Prot:Q96N95

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